Results 1 to 10 of about 71,280 (265)

S100A10-ANXA2 tetramer inhibition hampers hepatic stellate cell activation in human MASLD organoids [PDF]

EMBO Molecular Medicine
Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD), initiated by the pathological lipid accumulation within hepatocytes, can progress towards Metabolic dysfunction-Associated SteatoHepatitis (MASH) characterized by inflammation and fibrosis.
Miranda Türkal, Christine Maeder, Marta Correia de Sousa, Margot Fournier, Sanae El-Harane, Monika Gjorgjieva, Michelangelo Foti, Pierre Maechler, Etienne Delangre   +8 more
doaj   +2 more sources

Responses of hepatic sinusoidal cells to liver ischemia–reperfusion injury

Frontiers in Cell and Developmental Biology, 2023
The liver displays a remarkable regenerative capacity in response to acute liver injury. In addition to the proliferation of hepatocytes during liver regeneration, non-parenchymal cells, including liver macrophages, liver sinusoidal endothelial cells ...
Yoshiya Ito, Kanako Hosono, Hideki Amano
doaj   +1 more source

Stellate cell computational modeling predicts signal filtering in the molecular layer circuit of cerebellum

Scientific Reports, 2021
The functional properties of cerebellar stellate cells and the way they regulate molecular layer activity are still unclear. We have measured stellate cells electroresponsiveness and their activation by parallel fiber bursts.
Martina Francesca Rizza, Francesca Locatelli, Stefano Masoli, Diana Sánchez-Ponce, Alberto Muñoz, Francesca Prestori, Egidio D’Angelo   +6 more
doaj   +1 more source

Production of human entorhinal stellate cell-like cells by forward programming shows an important role of Foxp1 in reprogramming

Frontiers in Cell and Developmental Biology, 2022
Stellate cells are principal neurons in the entorhinal cortex that contribute to spatial processing. They also play a role in the context of Alzheimer’s disease as they accumulate Amyloid beta early in the disease.
Tobias Bergmann, Yong Liu, Jonathan Skov, Leo Mogus, Julie Lee, Julie Lee, Ulrich Pfisterer, Louis-Francois Handfield, Andrea Asenjo-Martinez, Irene Lisa-Vargas, Stefan E. Seemann, Jimmy Tsz Hang Lee, Nikolaos Patikas, Birgitte Rahbek Kornum, Mark Denham, Poul Hyttel, Menno P. Witter, Jan Gorodkin, Tune H. Pers, Martin Hemberg, Konstantin Khodosevich, Vanessa Jane Hall   +21 more
doaj   +1 more source

Inhibition of Renal Stellate Cell Activation Reduces Renal Fibrosis

Biomedicines, 2020
Interstitial fibrosis is a common feature of chronic kidney disease, and platelet-derived growth factor receptor-β (PDGFR-β)-positive mesenchymal cells are reportedly the major source of scar-producing myofibroblasts.
Jin Joo Cha, Chanchal Mandal, Jung Yeon Ghee, Ji Ae Yoo, Mi Jin Lee, Young Sun Kang, Young Youl Hyun, Ji Eun Lee, Hyun Wook Kim, Sang Youb Han, Jee Young Han, Ah Young Chung, Dae Wui Yoon, Im Joo Rhyu, Junseo Oh, Dae Ryong Cha   +15 more
doaj   +1 more source

GATA4 induces liver fibrosis regression by deactivating hepatic stellate cells

JCI Insight, 2021
In response to liver injury, hepatic stellate cells activate and acquire proliferative and contractile features. The regression of liver fibrosis appears to involve the clearance of activated hepatic stellate cells, either by apoptosis or by reversion ...
Noelia Arroyo, Laura Villamayor, Irene Díaz, Rita Carmona, Mireia Ramos-Rodríguez, Ramón Muñoz-Chápuli, Lorenzo Pasquali, Miguel G. Toscano, Franz Martín, David A. Cano, Anabel Rojas   +10 more
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Excitatory granule neuron precursors orchestrate laminar localization and differentiation of cerebellar inhibitory interneuron subtypes

Cell Reports, 2021
Summary: GABAergic interneurons migrate long distances through stereotyped migration programs toward specific laminar positions. During their migration, GABAergic interneurons are morphologically alike but then differentiate into a rich array of ...
Christelle Cadilhac, Isabelle Bachy, Antoine Forget, David J. Hodson, Céline Jahannault-Talignani, Andrew J. Furley, Olivier Ayrault, Patrice Mollard, Constantino Sotelo, Fabrice Ango   +9 more
doaj   +1 more source

Pancreatic Stellate Cells Serve as a Brake Mechanism on Pancreatic Acinar Cell Calcium Signaling Modulated by Methionine Sulfoxide Reductase Expression

Cells, 2019
Although methionine sulfoxide reductase (Msr) is known to modulate the activity of multiple functional proteins, the roles of Msr in pancreatic stellate cell physiology have not been reported.
Jin Shuai Liu, Zong Jie Cui
doaj   +1 more source

Effects of dietary retinoid and triglyceride on the lipid composition of rat liver stellate cells and stellate cell lipid droplets

Journal of Lipid Research, 1988
Hepatic stellate cells store the majority of the liver's retinoid (vitamin A) reserves as retinyl esters in stellate cell lipid droplets. A study was conducted to explore the effects of differences in dietary retinoid and triglyceride intake on the ...
H Moriwaki, W S Blaner, R Piantedosi, D S Goodman   +3 more
doaj   +1 more source

Purinergic Signaling in Liver Pathophysiology

Frontiers in Endocrinology, 2021
Extracellular nucleosides and nucleotides activate a group of G protein-coupled receptors (GPCRs) known as purinergic receptors, comprising adenosine and P2Y receptors. Furthermore, purinergic P2X ion channels are activated by ATP.
Shanu Jain, Kenneth A. Jacobson
doaj   +1 more source