Results 1 to 10 of about 70,904 (118)

Neuronal injury and hepatotoxicity: astrocytes and stellate cells convergence and their role in tissue repair [PDF]

Frontiers in Neuroscience
In the central nervous system, astrocytes are highly specialized non-neuronal cells that are key elements in maintaining neuronal microenvironment homeostasis.
Ana Catya Jimenez-Torres, Arturo Ortega, Mustapha Najimi   +2 more
doaj   +2 more sources

Recent Advances in the Study of Traditional Chinese Medicine in Reversing Hepatic Fibrosis Through the Regulation of Hepatic Stellate Cells Apoptosis Pathways [PDF]

Drug Design, Development and Therapy
Ruihan Cheng, Baolong Li Drug Safety Evaluation Center, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, 150006, People’s Republic of ChinaCorrespondence: Baolong Li, Drug Safety Evaluation Center, Heilongjiang University of ...
Cheng R, Li B
doaj   +2 more sources

Stellate cell computational modeling predicts signal filtering in the molecular layer circuit of cerebellum

Scientific Reports, 2021
The functional properties of cerebellar stellate cells and the way they regulate molecular layer activity are still unclear. We have measured stellate cells electroresponsiveness and their activation by parallel fiber bursts.
Martina Francesca Rizza, Francesca Locatelli, Stefano Masoli, Diana Sánchez-Ponce, Alberto Muñoz, Francesca Prestori, Egidio D’Angelo   +6 more
doaj   +1 more source

Production of human entorhinal stellate cell-like cells by forward programming shows an important role of Foxp1 in reprogramming

Frontiers in Cell and Developmental Biology, 2022
Stellate cells are principal neurons in the entorhinal cortex that contribute to spatial processing. They also play a role in the context of Alzheimer’s disease as they accumulate Amyloid beta early in the disease.
Tobias Bergmann, Yong Liu, Jonathan Skov, Leo Mogus, Julie Lee, Julie Lee, Ulrich Pfisterer, Louis-Francois Handfield, Andrea Asenjo-Martinez, Irene Lisa-Vargas, Stefan E. Seemann, Jimmy Tsz Hang Lee, Nikolaos Patikas, Birgitte Rahbek Kornum, Mark Denham, Poul Hyttel, Menno P. Witter, Jan Gorodkin, Tune H. Pers, Martin Hemberg, Konstantin Khodosevich, Vanessa Jane Hall   +21 more
doaj   +1 more source

GATA4 induces liver fibrosis regression by deactivating hepatic stellate cells

JCI Insight, 2021
In response to liver injury, hepatic stellate cells activate and acquire proliferative and contractile features. The regression of liver fibrosis appears to involve the clearance of activated hepatic stellate cells, either by apoptosis or by reversion ...
Noelia Arroyo, Laura Villamayor, Irene Díaz, Rita Carmona, Mireia Ramos-Rodríguez, Ramón Muñoz-Chápuli, Lorenzo Pasquali, Miguel G. Toscano, Franz Martín, David A. Cano, Anabel Rojas   +10 more
doaj   +1 more source

Inhibiting IRE1α-endonuclease activity decreases tumor burden in a mouse model for hepatocellular carcinoma

eLife, 2020
Hepatocellular carcinoma (HCC) is a liver tumor that usually arises in patients with cirrhosis. Hepatic stellate cells are key players in the progression of HCC, as they create a fibrotic micro-environment and produce growth factors and cytokines that ...
Nataša Pavlović, Carlemi Calitz, Kess Thanapirom, Guiseppe Mazza, Krista Rombouts, Pär Gerwins, Femke Heindryckx   +6 more
doaj   +1 more source

Toll-like receptor 5 tunes hepatic and pancreatic stellate cells activation

BMJ Open Gastroenterology, 2023
Objective Stellate cells are responsible for liver and pancreas fibrosis and strictly correlate with tumourigenesis. Although their activation is reversible, an exacerbated signalling triggers chronic fibrosis.
Malte Buchholz, Detlef Schuppan, Pietro Di Fazio, Sophia Mielke, Isabell T Böhm, Sami Matrood, Thaddeus Wissniowski   +6 more
doaj   +1 more source

The Wilms' tumor suppressor gene regulates pancreas homeostasis and repair. [PDF]

PLoS Genetics, 2019
The Wilms' tumor suppressor gene (Wt1) encodes a zinc finger transcription factor that plays an essential role in the development of kidneys, gonads, spleen, adrenals and heart.
Laura Ariza, Anabel Rojas, Ramón Muñoz-Chápuli, Rita Carmona   +3 more
doaj   +1 more source

Replacement of retinyl esters by polyunsaturated triacylglycerol species in lipid droplets of hepatic stellate cells during activation. [PDF]

PLoS ONE, 2012
Activation of hepatic stellate cells has been recognized as one of the first steps in liver injury and repair. During activation, hepatic stellate cells transform into myofibroblasts with concomitant loss of their lipid droplets (LDs) and production of ...
Nicole Testerink, Mokrish Ajat, Martin Houweling, Jos F Brouwers, Vishnu V Pully, Henk-Jan van Manen, Cees Otto, J Bernd Helms, Arie B Vaandrager   +8 more
doaj   +1 more source

Storage of vitamin A in extrahepatic stellate cells in normal rats

Journal of Lipid Research, 1997
In mammals, vitamin A is primarily stored as retinyl esters in hepatic stellate cells under normal dietary intake of the vitamin. Previously, extrahepatic vitamin A-storing stellate cells have only been identified in animals maintained on a vitamin A ...
N E Nagy, K B Holven, N Roos, H Senoo, N Kojima, K R Norum, R Blomhoff   +6 more
doaj   +1 more source