Pancreatic stellate cells in pancreatic cancer: as potential targets for future therapy [PDF]
Frontiers in Oncology, 2023 Pancreatic cancer is a strongly malignant gastrointestinal carcinoma characterized by late detection, high mortality rates, poor patient prognosis and lack of effective treatments.
Zhengfeng Wang +4 more
doaj +2 more sources
Toll-like receptor 5 tunes hepatic and pancreatic stellate cells activation [PDF]
BMJ Open Gastroenterology, 2023 Objective Stellate cells are responsible for liver and pancreas fibrosis and strictly correlate with tumourigenesis. Although their activation is reversible, an exacerbated signalling triggers chronic fibrosis.
Malte Buchholz +6 more
doaj +2 more sources
Role of Pancreatic Stellate Cells in Chemoresistance in Pancreatic Cancer
Frontiers in Physiology, 2014 Pancreatic cancer is highly chemoresistant. A major contributing factor is the characteristic extensive stromal or fibrotic reaction, which comprises up to 90% of the tumour volume.
Joshua eMcCarroll +9 more
doaj +3 more sources
Cells, 2019 Although methionine sulfoxide reductase (Msr) is known to modulate the activity of multiple functional proteins, the roles of Msr in pancreatic stellate cell physiology have not been reported.
Jin Shuai Liu, Zong Jie Cui
doaj +3 more sources
Isolation of Murine Pancreatic Stellate Cells and the Establishment of a New ex-vivo Activation Model [PDF]
Clinical and Experimental GastroenterologyXinye Wang,1,* Miaomiao Li,1,* Xinjuan Liu,1 Guangyong Sun,1,2 Dong Zhang,1,2 Lijun Sun,3 Yue Yin,4 Weizhen Zhang,3 Jianyu Hao1 1Department of Gastroenterology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020 ...
Wang X +8 more
doaj +2 more sources
Activation and Regulation of Pancreatic Stellate Cells in Chronic Pancreatic Fibrosis: A Potential Therapeutic Approach for Chronic Pancreatitis [PDF]
BiomedicinesIn the complex progression of fibrosis in chronic pancreatitis, pancreatic stellate cells (PSCs) emerge as central figures. These cells, initially in a dormant state characterized by the storage of vitamin A lipid droplets within the chronic pancreatitis
Fanyi Kong, Yingyu Pan, Dong Wu
doaj +2 more sources
iScience, 2023 Summary: Pancreatic stellate cells (PSCs) are suggested to play an important role in the development of pancreas and islet fibrosis. However, the precise contributions and solid in vivo evidence of PSCs to the fibrogenesis remain to be elucidated.
Jinbang Wang +11 more
doaj +1 more source
The Wilms' tumor suppressor gene regulates pancreas homeostasis and repair. [PDF]
PLoS Genetics, 2019 The Wilms' tumor suppressor gene (Wt1) encodes a zinc finger transcription factor that plays an essential role in the development of kidneys, gonads, spleen, adrenals and heart.
Laura Ariza +3 more
doaj +1 more source
The effect of conditioned media on the cellular proliferation of pancreatic cancer cells, pancreatic stellate cells, and myeloid-derived suppressor cells [PDF]
World Cancer Research JournalObjective: Pancreatic cancer has remained one of the most devastating diseases over the past two decades, with minimal improvements in survival rates. Its highly immunosuppressive tumour microenvironment is driven by secreted proteins, such as cytokines ...
Y. Chong +7 more
doaj +1 more source
A novel pancreatic tumour and stellate cell 3D co-culture spheroid model
BMC Cancer, 2020 Background Pancreatic ductal adenocarcinoma is a devastating disease with poor outcome, generally characterized by an excessive stroma component. The purpose of this study was to develop a simple and reproducible in vitro 3D-assay employing the main ...
K. J. Norberg +9 more
doaj +1 more source