Role of Pancreatic Stellate Cells in Chemoresistance in Pancreatic Cancer [PDF]
Frontiers in Physiology, 2014 Pancreatic cancer is highly chemoresistant. A major contributing factor is the characteristic extensive stromal or fibrotic reaction, which comprises up to 90% of the tumour volume.
Joshua eMcCarroll +9 more
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Isolation of Murine Pancreatic Stellate Cells and the Establishment of a New ex-vivo Activation Model [PDF]
Clinical and Experimental GastroenterologyXinye Wang,1,* Miaomiao Li,1,* Xinjuan Liu,1 Guangyong Sun,1,2 Dong Zhang,1,2 Lijun Sun,3 Yue Yin,4 Weizhen Zhang,3 Jianyu Hao1 1Department of Gastroenterology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020 ...
Wang X +8 more
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Pancreatic stellate cells in pancreatic cancer: as potential targets for future therapy [PDF]
Frontiers in Oncology, 2023 Pancreatic cancer is a strongly malignant gastrointestinal carcinoma characterized by late detection, high mortality rates, poor patient prognosis and lack of effective treatments.
Zhengfeng Wang +4 more
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Toll-like receptor 5 tunes hepatic and pancreatic stellate cells activation [PDF]
BMJ Open Gastroenterology, 2023 Objective Stellate cells are responsible for liver and pancreas fibrosis and strictly correlate with tumourigenesis. Although their activation is reversible, an exacerbated signalling triggers chronic fibrosis.
Malte Buchholz +6 more
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Pancreatic stellate cells - rising stars in pancreatic pathologies. [PDF]
Physiol Res, 2021 Pluripotent pancreatic stellate cells (PSCs) receive growing interest in past decades. Two types of PSCs are recognized –vitamin A accumulating quiescent PSCs and activated PSCs- the main producents of extracellular matrix in pancreatic tissue.
Hrabák P +3 more
europepmc +3 more sources
A Rising Star in Pancreatic Diseases: Pancreatic Stellate Cells [PDF]
Frontiers in Physiology, 2018 Pancreatic stellate cell (PSC) is a type of pluripotent cell located between pancreatic lobules and the surrounding area of acinars. When activated, PSC can be transformed into myofibroblast-like cell.
Ran Xue +6 more
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Repositioning of duloxetine to target pancreatic stellate cells. [PDF]
Oncol Lett, 2021 Pancreatic cancer cells (PCCs) are surrounded by an abundant stroma, which is produced by pancreatic stellate cells (PSCs). PSCs promote tumor cell proliferation and invasion. The objective of the current study was to identify compounds that suppress PSC activation. Gene expression profiles of cancer-derived fibroblasts and normal fibroblasts were used,
Sagara A +8 more
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Activation and Regulation of Pancreatic Stellate Cells in Chronic Pancreatic Fibrosis: A Potential Therapeutic Approach for Chronic Pancreatitis [PDF]
BiomedicinesIn the complex progression of fibrosis in chronic pancreatitis, pancreatic stellate cells (PSCs) emerge as central figures. These cells, initially in a dormant state characterized by the storage of vitamin A lipid droplets within the chronic pancreatitis
Fanyi Kong, Yingyu Pan, Dong Wu
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Molecular regulation of pancreatic stellate cell function
Molecular Cancer, 2004 Until now, no specific therapies are available to inhibit pancreatic fibrosis, a constant pathological feature of chronic pancreatitis and pancreatic cancer. One major reason is the incomplete knowledge of the molecular principles underlying fibrogenesis
Jaster Robert
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iScience, 2023 Summary: Pancreatic stellate cells (PSCs) are suggested to play an important role in the development of pancreas and islet fibrosis. However, the precise contributions and solid in vivo evidence of PSCs to the fibrogenesis remain to be elucidated.
Jinbang Wang +11 more
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