Results 41 to 50 of about 4,592,636 (274)

How fibrosis influences imaging and surgical decisions in pancreatic cancer

Frontiers in Physiology, 2012
Our understanding of pancreatic ductal adenocarcinoma is shifting away from a disease of malignant ductal cells-only, towards a complex system where tumor evolution is a result of interaction of cancer cells with their microenvironment.
Mert eErkan, Simone eHausmann, Christoph W Michalski, Melissa eSchlitter, Alexander A Fingerle, Martin eDobritz, Helmut eFriess, Jörg eKleeff   +7 more
doaj   +1 more source

Functional IKK/NF-κB signaling in pancreatic stellate cells is essential to prevent autoimmune pancreatitis

Communications Biology, 2022
A model of autoimmune pancreatitis is developed by blocking the activation of NF-κB in pancreatic stellate cells, via conditional deletion of NEMO (IKKγ), which presents strong pancreatic inflammation with eosinophilia after the induction of chronic ...
Lap Kwan Chan, Miltiadis Tsesmelis, Melanie Gerstenlauer, Frank Leithäuser, Alexander Kleger, Lukas Daniel Frick, Harald Jacob Maier, Thomas Wirth   +7 more
doaj   +1 more source

Scoparone Protects Against Pancreatic Fibrosis via TGF-β/Smad Signaling in Rats

Cellular Physiology and Biochemistry, 2016
Background/Aims: This study was to investigate the influence of scoparone on pancreatic fibrosis in vitro and in vivo. Methods: Pancreatic stellate cells (PSCs) were isolated from pancreas tissue blocks, and cultured for 3-5 generations for the ...
Min Xu, Jing Cai, Hong Wei, Meng Zhou, Ping Xu, Hongmei Huang, Wanxin Peng, Fengyi Du, Aihua Gong, Youli Zhang   +9 more
doaj   +1 more source

Pancreatic stellate cells in the islets as a novel target to preserve the pancreatic β‐cell mass and function

Journal of Diabetes Investigation, 2020
There are numerous lines of clinical evidence that inhibition of the renin–angiotensin system (RAS) can prevent and delay the development of diabetes.
Yeoree Yang, Ji‐Won Kim, Heon‐Seok Park, Eun‐Young Lee, Kun‐Ho Yoon   +4 more
doaj   +1 more source

Molecular Analysis of Precursor Lesions in Familial Pancreatic Cancer [PDF]

, 2013
PMCID: PMC3553106This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Stipo Jurcevic (276415), Bhakta Vipul, Bronner, Mary, Harada, Tomohiko, Barry Sayka, Bronner, M, Mary Bronner (276416), Lattimore Sam, Lemoine Nicholas R., Tomohiko Harada, Teresa A Brentnall, Crnogorac-Jurcevic, Tatjana, Claude Chelala, Brentnall, TA, Mary Bronner, Sam Lattimore (276414), Lattimore, Sam, Tatjana Crnogorac-Jurcevic (57627), Brentnall, Teresa A, Bhakta, V, Crnogorac-Jurcevic, T, Bronner Mary, Teresa A. Brentnall (186815), Chelala, C, Nicholas R. Lemoine (276417), Jurcevic, Stipo, Barry, Sayka, Brentnall Teresa A., Sam Lattimore, Crnogorac-Jurcevic Tatjana, Lemoine, Nicholas R, Lemoine, NR, Lattimore, S, Jurcevic Stipo, Nicholas R Lemoine, Sayka Barry, Tomohiko Harada (276412), Chelala Claude, Harada, T, Stipo Jurcevic, Barry, S, Vipul Bhakta (276413), Chelala, Claude, Jurcevic, S, Bhakta, Vipul, Vipul Bhakta, Sayka Barry (57623), Tatjana Crnogorac-Jurcevic, Claude Chelala (3016), Harada Tomohiko   +49 more
core   +1 more source

Pancreatic Cancer: The Role of Pancreatic Stellate Cells in Tumor Progression [PDF]

Pancreatology, 2011
Pancreatic ductal adenocarcinoma is an aggressive and highly lethal disease frequently characterized by a dense stromal or desmoplastic response. Accumulating evidence exists that tumor desmoplasia plays a central role in disease progression and that e.g. activated pancreatic stellate cells (PSCs) are responsible for the excess matrix production.
Dunér, Siri, Lopatko Lindman, Jacob, Ansari, Daniel, Gundewar, Chinmay, Andersson, Roland   +4 more
openaire   +3 more sources

Parameter identifiability and sensitivity analysis predict targets for enhancement of STAT1 activity in pancreatic cancer and stellate cells.

PLoS Computational Biology, 2012
The present work exemplifies how parameter identifiability analysis can be used to gain insights into differences in experimental systems and how uncertainty in parameter estimates can be handled.
Katja Rateitschak, Felix Winter, Falko Lange, Robert Jaster, Olaf Wolkenhauer   +4 more
doaj   +1 more source

N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1. [In supplement: 11th International Symposium on the Cells of the Hepatic Sinusoid and their Relation to Other Cells] [PDF]

, 2004
Apoptosis of hepatic stellate cells (HSC) has previously been shown to occur during spontaneous resolution of experimental liver fibrosis. TIMP-1 has also been shown to have a key role because of its ability to inhibit apoptosis of HSC via matrix ...
Iredale, John P., Julian Waung, Derek Mann, R Christopher Benyon, Collins, Jane, Arthur, Michael J.P., Murphy, Frank, Nagase, Hideaki, Hideaki Nagase, John P Iredale, Mann, Derek, Frank Murphy, Waung, Julian, Jane Collins, Benyon, R. Christopher, Michael JP Arthur   +15 more
core   +1 more source

Cannabinoids reduce markers of inflammation and fibrosis in pancreatic stellate cells.

PLoS ONE, 2008
BackgroundWhile cannabinoids have been shown to ameliorate liver fibrosis, their effects in chronic pancreatitis and on pancreatic stellate cells (PSC) are unknown.Methodology/principal findingsThe activity of the endocannabinoid system was evaluated in ...
Christoph W Michalski, Milena Maier, Mert Erkan, Danguole Sauliunaite, Frank Bergmann, Pal Pacher, Sandor Batkai, Nathalia A Giese, Thomas Giese, Helmut Friess, Jörg Kleeff   +10 more
doaj   +1 more source

Immune cell responses in pancreatic cancer and their clinical application

European Journal of Inflammation, 2022
Pancreatic cancer is one of the most lethal diseases around the world, for hardly detection and poor prognosis. Recent years, functions of the tumor microenvironment and immune cells attract people’s view and there is emerging evidence implicating some ...
Xulin Zhou, Yongmin Yan, Min Xu
doaj   +1 more source