Results 21 to 30 of about 18,206 (254)

Pancreatic Stellate Cells: Partners in Crime with Pancreatic Cancer Cells [PDF]

Cancer Research, 2008
Abstract Pancreatic stellate cells (PSC) produce the stromal reaction in pancreatic cancer, but their role in cancer progression is not fully elucidated. We examined the influence of PSCs on pancreatic cancer growth using (a) an orthotopic model of pancreatic cancer and (b) cultured human PSCs (hPSC) and human pancreatic cancer cell ...
Vonlaufen, Alain, Joshi, Swapna, Qu, Changfa, Phillips, Phoebe A, Xu, Zhihong, Parker, Nicole R, Toi, Cheryl S, Pirola, Ron, Wilson, Jeremy S, Goldstein, David, Apte, Minoti V   +10 more
openaire   +3 more sources

Retinoids in Stellate Cells: Development, Repair, and Regeneration

Journal of Developmental Biology, 2019
Stellate cells, either hepatic (HSCs) or pancreatic (PSCs), are a type of interstitial cells characterized by their ability to store retinoids in lipid vesicles. In pathological conditions both HSCs and PSCs lose their retinoid content and transform into
Rita Carmona, Silvia Barrena, Ramón Muñoz-Chápuli   +2 more
doaj   +1 more source

Progress of Pancreatic Stellate Cells in Research of Pancreatic Disease Model

Shiyan dongwu yu bijiao yixue, 2022
Common types of pancreatic diseases are pancreatitis, diabetes and pancreatic cancer. Clinical studies have found that pancreatic stellate cells (PSCs) in patients with pancreatic diseases, contributes to fibrosis, oxidative stress and inflammation, and ...
WEI Xun, JIANG Xia, ZHENG Yuxuan, ZHANG Lewen, ZHOU Zhengyu   +4 more
doaj   +1 more source

Apigenin inhibits pancreatic stellate cell activity in pancreatitis [PDF]

Journal of Surgical Research, 2015
Chronic pancreatitis (CP) is characterized by recurrent pancreatic injury, resulting in inflammation, necrosis, and fibrosis. There are currently no drugs limiting pancreatic fibrosis associated with CP, and there is a definite need to fill this void in patient care.Pancreatitis was induced in C57/BL6 mice using supraphysiologic doses of cerulein, and ...
Amy A. Mrazek, Laura J. Porro, Vandanajay Bhatia, Miriam Falzon, Heidi Spratt, Jia Zhou, Celia Chao, Mark R. Hellmich   +7 more
openaire   +2 more sources

Organ-, inflammation- and cancer specific transcriptional fingerprints of pancreatic and hepatic stellate cells

Molecular Cancer, 2010
Background Tissue fibrosis is an integral component of chronic inflammatory (liver and pancreas) diseases and pancreatic cancer. Activated pancreatic- (PSC) and hepatic- (HSC) stellate cells play a key role in fibrogenesis. To identify organ- and disease-
Huber Peter E, Debus Jürgen, Ansorge Wilhelm, Giese Nathalia A, Wirkner Ute, Jiang Xiaohua, Samkharadze Tamar, Schwager Christian, Pan Zheng, Weis Nadine, Erkan Mert, Friess Helmut, Abdollahi Amir, Kleeff Jörg   +13 more
doaj   +1 more source

Role of the Tumor Microenvironment in Regulating Pancreatic Cancer Therapy Resistance

Cells, 2022
Pancreatic cancer has a notoriously poor prognosis, exhibits persistent drug resistance, and lacks a cure. Unique features of the pancreatic tumor microenvironment exacerbate tumorigenesis, metastasis, and therapy resistance. Recent studies emphasize the
Daiyong Deng, Riya Patel, Cheng-Yao Chiang, Pingping Hou   +3 more
doaj   +1 more source

Role of Pancreatic Stellate Cells in Pancreatic Cancer Metastasis [PDF]

The American Journal of Pathology, 2010
Pancreatic stellate cells (PSCs) produce the stromal reaction in pancreatic cancer (PC), and their interaction with cancer cells facilitates cancer progression. This study investigated the role of human PSCs (hPSCs) in the metastatic process and tumor angiogenesis using both in vivo (orthotopic model) and in vitro (cultured PSC and PC cells) approaches.
Zhihong, Xu, Alain, Vonlaufen, Phoebe A, Phillips, Eva, Fiala-Beer, Xuguo, Zhang, Lu, Yang, Andrew V, Biankin, David, Goldstein, Romano C, Pirola, Jeremy S, Wilson, Minoti V, Apte   +10 more
openaire   +2 more sources

ROLE OF PANCREATIC STELLATE CELLS IN PROGRESSION OF PANCREATIC CANCER

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2018
The present review analyzes literature data about the relationship between stellate and cancer cells of the pancreas and their possible role in the progression of cancer.
Mozheiko L. A.
doaj   +1 more source

SARS-CoV-2 S Protein Subunit 1 Elicits Ca2+ Influx – Dependent Ca2+ Signals in Pancreatic Stellate Cells and Macrophages In Situ

Function, 2022
The S protein subunit 1 (S1) of SARS-CoV-2 is known to be responsible for the binding of the virus to host cell receptors, but the initial intracellular signalling steps following receptor activation of cells in the exocrine pancreas are unknown.
Julia V Gerasimenko, Ole H Petersen, Oleg V Gerasimenko   +2 more
doaj   +1 more source

What are the macrophages and stellate cells doing in pancreatic adenocarcinoma?

Frontiers in Physiology, 2015
Pancreatic ductal adenocarcinoma is a devastating disease characterized by a dense desmoplastic stroma. Chemo- and radio-therapeutic strategies based on targeting cancer cells have failed in improving the outcome of this cancer suggesting important roles
Stephen J Pandol, Mouad eEdderkaoui
doaj   +1 more source