Results 21 to 30 of about 4,592,636 (274)

Signal transduction in pancreatic stellate cells [PDF]

Journal of Gastroenterology, 2009
Pancreatic fibrosis is a characteristic feature of chronic pancreatitis and of desmoplastic reaction associated with pancreatic cancer. For over a decade, there has been accumulating evidence that activated pancreatic stellate cells (PSCs) play a pivotal role in the development of pancreatic fibrosis in these pathological settings.
Atsushi, Masamune, Tooru, Shimosegawa
openaire   +2 more sources

Targeting Pancreatic Stellate Cells in Cancer [PDF]

Trends in Cancer, 2019
Pancreatic stellate cells (PSCs) are the major contributor to the aggressive, metastatic, and resilient nature of pancreatic ductal adenocarcinoma (PDAC), which has a poor prognosis with a 5-year survival rate of 8%. PSCs constitute more than 50% of the tumor stroma in PDAC, where they induce extensive desmoplasia by secreting abundant extracellular ...
Jonas Schnittert, Ruchi Bansal, Jai Prakash   +2 more
openaire   +2 more sources

A novel pancreatic tumour and stellate cell 3D co-culture spheroid model

BMC Cancer, 2020
Background Pancreatic ductal adenocarcinoma is a devastating disease with poor outcome, generally characterized by an excessive stroma component. The purpose of this study was to develop a simple and reproducible in vitro 3D-assay employing the main ...
K. J. Norberg, X. Liu, C. Fernández Moro, C. Strell, S. Nania, M. Blümel, A. Balboni, B. Bozóky, R. L. Heuchel, J. M. Löhr   +9 more
doaj   +1 more source

A Transcriptional Sequencing Analysis of Islet Stellate Cell and Pancreatic Stellate Cell [PDF]

Journal of Diabetes Research, 2018
Background. Our previous studies have shown that islet stellate cell (ISC), similar to pancreatic stellate cell (PSC) in phenotype and biological characters, may be responsible for the islet fibrosis in type 2 diabetes. To further identify the differences between PSC and ISC and for better understanding of the physiological function of ISC, we employed
Xiaohang Wang, Wei Li, Juan Chen, Sheng Zhao, Shanhu Qiu, Han Yin, Vladmir Carvalho, Yunting Zhou, Ruifeng Shi, Jiannan Hu, Shenyi Li, Munire Nijiati, Zilin Sun   +12 more
openaire   +3 more sources

Human pancreatic cancer-associated stellate cells remain activated after in vivo chemoradiation

Frontiers in Oncology, 2014
Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extensive fibrotic reaction or desmoplasia and complex involvement of the surrounding tumor microenvironment.
Marina Carla Cabrera, Marina Carla Cabrera, Estifanos eTilahun, Rebecca eNakles, Edgar eDiaz-Cruz, Edgar eDiaz-Cruz, Aline eCharabaty, Simeng eSuy, Simeng eSuy, Patrick eJackson, Lisa eLey, Rebecca eSlack, Reena eJha, Sean P Collins, Sean P Collins, Nadim eHaddad, Bhaskar V.S. Kallakury, Bhaskar V.S. Kallakury, Timm eSchroeder, Michael J Pishvaian, Michael J Pishvaian, Michael J Pishvaian, Priscilla A Furth, Priscilla A Furth   +23 more
doaj   +1 more source

Retinoids in Stellate Cells: Development, Repair, and Regeneration

Journal of Developmental Biology, 2019
Stellate cells, either hepatic (HSCs) or pancreatic (PSCs), are a type of interstitial cells characterized by their ability to store retinoids in lipid vesicles. In pathological conditions both HSCs and PSCs lose their retinoid content and transform into
Rita Carmona, Silvia Barrena, Ramón Muñoz-Chápuli   +2 more
doaj   +1 more source

Progress of Pancreatic Stellate Cells in Research of Pancreatic Disease Model

Shiyan dongwu yu bijiao yixue, 2022
Common types of pancreatic diseases are pancreatitis, diabetes and pancreatic cancer. Clinical studies have found that pancreatic stellate cells (PSCs) in patients with pancreatic diseases, contributes to fibrosis, oxidative stress and inflammation, and ...
WEI Xun, JIANG Xia, ZHENG Yuxuan, ZHANG Lewen, ZHOU Zhengyu   +4 more
doaj   +1 more source

Role of Pancreatic Stellate Cells in Pancreatic Cancer Metastasis [PDF]

The American Journal of Pathology, 2010
Pancreatic stellate cells (PSCs) produce the stromal reaction in pancreatic cancer (PC), and their interaction with cancer cells facilitates cancer progression. This study investigated the role of human PSCs (hPSCs) in the metastatic process and tumor angiogenesis using both in vivo (orthotopic model) and in vitro (cultured PSC and PC cells) approaches.
Zhihong, Xu, Alain, Vonlaufen, Phoebe A, Phillips, Eva, Fiala-Beer, Xuguo, Zhang, Lu, Yang, Andrew V, Biankin, David, Goldstein, Romano C, Pirola, Jeremy S, Wilson, Minoti V, Apte   +10 more
openaire   +2 more sources

Tracing cell lineages in health and disease: experimental and human studies [PDF]

, 2010
PhDThis study aimed to investigate stem cell biology in the normal and diseased pancreas and liver employing robust methods for tracking stem cells and their progeny in both pre-clinical and human scenario.
Lin, Wey-Ran
core   +4 more sources

Role of the Tumor Microenvironment in Regulating Pancreatic Cancer Therapy Resistance

Cells, 2022
Pancreatic cancer has a notoriously poor prognosis, exhibits persistent drug resistance, and lacks a cure. Unique features of the pancreatic tumor microenvironment exacerbate tumorigenesis, metastasis, and therapy resistance. Recent studies emphasize the
Daiyong Deng, Riya Patel, Cheng-Yao Chiang, Pingping Hou   +3 more
doaj   +1 more source