Results 11 to 20 of about 18,206 (254)
A Rising Star in Pancreatic Diseases: Pancreatic Stellate Cells [PDF]
Frontiers in Physiology, 2018 Pancreatic stellate cell (PSC) is a type of pluripotent cell located between pancreatic lobules and the surrounding area of acinars. When activated, PSC can be transformed into myofibroblast-like cell.
Ran Xue +6 more
doaj +3 more sources
Molecular regulation of pancreatic stellate cell function
Molecular Cancer, 2004 Until now, no specific therapies are available to inhibit pancreatic fibrosis, a constant pathological feature of chronic pancreatitis and pancreatic cancer. One major reason is the incomplete knowledge of the molecular principles underlying fibrogenesis
Jaster Robert
doaj +3 more sources
Pancreatic stellate cells - rising stars in pancreatic pathologies. [PDF]
Physiol Res, 2021 Pluripotent pancreatic stellate cells (PSCs) receive growing interest in past decades. Two types of PSCs are recognized –vitamin A accumulating quiescent PSCs and activated PSCs- the main producents of extracellular matrix in pancreatic tissue.
Hrabák P +3 more
europepmc +3 more sources
Signal transduction in pancreatic stellate cells [PDF]
Journal of Gastroenterology, 2009 Pancreatic fibrosis is a characteristic feature of chronic pancreatitis and of desmoplastic reaction associated with pancreatic cancer. For over a decade, there has been accumulating evidence that activated pancreatic stellate cells (PSCs) play a pivotal role in the development of pancreatic fibrosis in these pathological settings.
Atsushi, Masamune, Tooru, Shimosegawa
openaire +2 more sources
Targeting Pancreatic Stellate Cells in Cancer [PDF]
Trends in Cancer, 2019 Pancreatic stellate cells (PSCs) are the major contributor to the aggressive, metastatic, and resilient nature of pancreatic ductal adenocarcinoma (PDAC), which has a poor prognosis with a 5-year survival rate of 8%. PSCs constitute more than 50% of the tumor stroma in PDAC, where they induce extensive desmoplasia by secreting abundant extracellular ...
Jonas Schnittert +2 more
openaire +2 more sources
Interaction of Stellate Cells with Pancreatic Carcinoma Cells [PDF]
Cancers, 2010 Pancreatic cancer is characterized by its late detection, aggressive growth, intense infiltration into adjacent tissue, early metastasis, resistance to chemo- and radiotherapy and a strong “desmoplastic reaction”. The dense stroma surrounding carcinoma cells is composed of fibroblasts, activated stellate cells (myofibroblast-like cells), various ...
Habisch, Hansjörg +3 more
openaire +2 more sources
A Transcriptional Sequencing Analysis of Islet Stellate Cell and Pancreatic Stellate Cell [PDF]
Journal of Diabetes Research, 2018 Background. Our previous studies have shown that islet stellate cell (ISC), similar to pancreatic stellate cell (PSC) in phenotype and biological characters, may be responsible for the islet fibrosis in type 2 diabetes. To further identify the differences between PSC and ISC and for better understanding of the physiological function of ISC, we employed
Xiaohang Wang +12 more
openaire +3 more sources
Repositioning of duloxetine to target pancreatic stellate cells. [PDF]
Oncol Lett, 2021 Pancreatic cancer cells (PCCs) are surrounded by an abundant stroma, which is produced by pancreatic stellate cells (PSCs). PSCs promote tumor cell proliferation and invasion. The objective of the current study was to identify compounds that suppress PSC activation. Gene expression profiles of cancer-derived fibroblasts and normal fibroblasts were used,
Sagara A +8 more
europepmc +4 more sources
Pancreatic Stellate Cells and Pancreatic Cancer Cells: An Unholy Alliance [PDF]
Cancer Research, 2008 Abstract Pancreatic cancer—a tumor displaying a particularly abundant stromal reaction—is notorious for its poor prognosis. Recent studies, via newly developed orthotopic models, provide compelling evidence of an important role for pancreatic stellate cells (PSC) in pancreatic cancer progression.
Alain, Vonlaufen +6 more
openaire +2 more sources
Human pancreatic cancer-associated stellate cells remain activated after in vivo chemoradiation
Frontiers in Oncology, 2014 Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extensive fibrotic reaction or desmoplasia and complex involvement of the surrounding tumor microenvironment.
Marina Carla Cabrera +23 more
doaj +1 more source