Results 11 to 20 of about 4,592,636 (274)

Pancreatic Stellate Cells and Pancreatic Cancer Cells: An Unholy Alliance [PDF]

Cancer Research, 2008
Abstract Pancreatic cancer—a tumor displaying a particularly abundant stromal reaction—is notorious for its poor prognosis. Recent studies, via newly developed orthotopic models, provide compelling evidence of an important role for pancreatic stellate cells (PSC) in pancreatic cancer progression.
Alain, Vonlaufen, Phoebe A, Phillips, Zhihong, Xu, David, Goldstein, Romano C, Pirola, Jeremy S, Wilson, Minoti V, Apte   +6 more
openaire   +3 more sources

ROLE OF PANCREATIC STELLATE CELLS IN PROGRESSION OF PANCREATIC CANCER

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2018
The present review analyzes literature data about the relationship between stellate and cancer cells of the pancreas and their possible role in the progression of cancer.
Mozheiko L. A.
doaj   +2 more sources

The effect of conditioned media on the cellular proliferation of pancreatic cancer cells, pancreatic stellate cells, and myeloid-derived suppressor cells [PDF]

World Cancer Research Journal
Objective: Pancreatic cancer has remained one of the most devastating diseases over the past two decades, with minimal improvements in survival rates. Its highly immunosuppressive tumour microenvironment is driven by secreted proteins, such as cytokines ...
Y. Chong, S. Samsudin, D. Bahrani, C. Chang, A. Masamune, S. Ng, N. Ismail, K. Ho   +7 more
doaj   +3 more sources

Interaction of Stellate Cells with Pancreatic Carcinoma Cells [PDF]

Cancers, 2010
Pancreatic cancer is characterized by its late detection, aggressive growth, intense infiltration into adjacent tissue, early metastasis, resistance to chemo- and radiotherapy and a strong “desmoplastic reaction”. The dense stroma surrounding carcinoma cells is composed of fibroblasts, activated stellate cells (myofibroblast-like cells), various ...
Habisch, Hansjörg, Zhou, Shaoxia, Siech, Marco, Bachem, Max G.   +3 more
openaire   +3 more sources

Pancreatic Stellate Cells Serve as a Brake Mechanism on Pancreatic Acinar Cell Calcium Signaling Modulated by Methionine Sulfoxide Reductase Expression

Cells, 2019
Although methionine sulfoxide reductase (Msr) is known to modulate the activity of multiple functional proteins, the roles of Msr in pancreatic stellate cell physiology have not been reported.
Jin Shuai Liu, Zong Jie Cui
doaj   +2 more sources

Pancreatic Stellate Cells: Partners in Crime with Pancreatic Cancer Cells [PDF]

Cancer Research, 2008
Abstract Pancreatic stellate cells (PSC) produce the stromal reaction in pancreatic cancer, but their role in cancer progression is not fully elucidated. We examined the influence of PSCs on pancreatic cancer growth using (a) an orthotopic model of pancreatic cancer and (b) cultured human PSCs (hPSC) and human pancreatic cancer cell ...
Vonlaufen, Alain, Joshi, Swapna, Qu, Changfa, Phillips, Phoebe A, Xu, Zhihong, Parker, Nicole R, Toi, Cheryl S, Pirola, Ron, Wilson, Jeremy S, Goldstein, David, Apte, Minoti V   +10 more
openaire   +4 more sources

Activation of Pancreatic Stellate Cells in Human and Experimental Pancreatic Fibrosis [PDF]

The American Journal of Pathology, 1999
The mechanisms of pancreatic fibrosis are poorly understood. In the liver, stellate cells play an important role in fibrogenesis. Similar cells have recently been isolated from the pancreas and are termed pancreatic stellate cells. The aim of this study was to determine whether pancreatic stellate cell activation occurs during experimental and human ...
Haber, P. S., Keogh, G. W., Apte, M. V., Moran, C. S., Stewart, N. L., Crawford, D. H. G., Pirola, R. C., McCaughan, G. W., Ramm, G. A., Wilson, J. S.   +9 more
openaire   +6 more sources

Tumour–stroma interactions in an organotypic culture model of pancreatic cancer [PDF]

, 2011
PhDPancreatic cancer is characterised by an intense fibrotic, or desmoplastic, stroma, which contributes to tumour progression. Three-dimensional in vitro culture models incorporating this non-tumour component may more closely recapitulate the ...
Froeling, Fieke E.M.
core   +4 more sources

The Wilms' tumor suppressor gene regulates pancreas homeostasis and repair. [PDF]

PLoS Genetics, 2019
The Wilms' tumor suppressor gene (Wt1) encodes a zinc finger transcription factor that plays an essential role in the development of kidneys, gonads, spleen, adrenals and heart.
Laura Ariza, Anabel Rojas, Ramón Muñoz-Chápuli, Rita Carmona   +3 more
doaj   +1 more source

Studies on the behaviour of human pancreatic carcinoma cell lines, with particular reference to stem cells [PDF]

, 2010
PhDStem cell therapy represents a potential -cell replacement strategy in diabetes and a pancreatic cancer (PC) stem cell is an attractive therapeutic target in this dire disease. However, a normal stem cell remains unidentified and proposed malignant
Guppy, Naomi J
core   +4 more sources