Results 31 to 40 of about 18,206 (254)
Pancreatic stellate cells induce angiogenesis
Suizo, 2008 膵星細胞は慢性膵炎や膵癌の際の線維化形成に中心的役割を果たす．最近，膵星細胞の多彩な細胞機能が明らかとなっている．今回，膵星細胞の血管新生誘導能について検討した．膵癌切除膵組織よりヒト膵星細胞を分離した．膵星細胞培養上清（CM）を作成し，ヒト臍静脈血管内皮細胞の増殖，遊走，細胞内シグナル伝達系に与える影響を検討した．更に，3次元管腔構造形成（in vitro血管新生能）ならびにヌードマウスの皮下でのin vivo血管新生誘導能についても検討した．CMは血管内皮細胞の増殖と遊走を刺激した．CMはERK系ならびにAkt系を活性化し，CMによる増殖ならびに遊走誘導は，これらのシグナル伝達系の抑制剤であるU0126およびwortmanninにより抑制された．CMは，in vitroおよびin ...
MASAMUNE, Atsushi +4 more
openaire +3 more sources
The pancreatic stellate cell: a star on the rise in pancreatic diseases [PDF]
Journal of Clinical Investigation, 2007 Pancreatic stellate cells (PaSCs) are myofibroblast-like cells found in the areas of the pancreas that have exocrine function. PaSCs are regulated by autocrine and paracrine stimuli and share many features with their hepatic counterparts, studies of which have helped further our understanding of PaSC biology.
M Bishr, Omary +3 more
openaire +2 more sources
Piezo1-mediated stellate cell activation causes pressure-induced pancreatic fibrosis in mice
JCI Insight, 2022 Pancreatic fibrosis is a complication of chronic pancreatitis and is a prominent feature of pancreatic cancer. Pancreatic fibrosis is commonly observed in patients with prolonged pancreatic duct obstruction, which elevates intrapancreatic pressure.
Sandip M. Swain +3 more
doaj +1 more source
Biomolecules, 2021 Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with a five-year survival rate of only 9%. PDAC is characterized by a dense, fibrotic stroma composed of extracellular matrix (ECM) proteins.
Ramiz S. Ahmad +3 more
doaj +1 more source
TRPM7 Modulates Human Pancreatic Stellate Cell Activation
Cells, 2022 Pancreatic diseases, such as pancreatitis or pancreatic ductal adenocarcinoma, are characterized by the presence of activated pancreatic stellate cells (PSCs).
Julie Auwercx +11 more
doaj +1 more source
How fibrosis influences imaging and surgical decisions in pancreatic cancer
Frontiers in Physiology, 2012 Our understanding of pancreatic ductal adenocarcinoma is shifting away from a disease of malignant ductal cells-only, towards a complex system where tumor evolution is a result of interaction of cancer cells with their microenvironment.
Mert eErkan +7 more
doaj +1 more source
Communications Biology, 2022 A model of autoimmune pancreatitis is developed by blocking the activation of NF-κB in pancreatic stellate cells, via conditional deletion of NEMO (IKKγ), which presents strong pancreatic inflammation with eosinophilia after the induction of chronic ...
Lap Kwan Chan +7 more
doaj +1 more source
Scoparone Protects Against Pancreatic Fibrosis via TGF-β/Smad Signaling in Rats
Cellular Physiology and Biochemistry, 2016 Background/Aims: This study was to investigate the influence of scoparone on pancreatic fibrosis in vitro and in vivo. Methods: Pancreatic stellate cells (PSCs) were isolated from pancreas tissue blocks, and cultured for 3-5 generations for the ...
Min Xu +9 more
doaj +1 more source
Activation of Pancreatic Stellate Cells in Human and Experimental Pancreatic Fibrosis [PDF]
The American Journal of Pathology, 1999 The mechanisms of pancreatic fibrosis are poorly understood. In the liver, stellate cells play an important role in fibrogenesis. Similar cells have recently been isolated from the pancreas and are termed pancreatic stellate cells. The aim of this study was to determine whether pancreatic stellate cell activation occurs during experimental and human ...
Haber, P. S. +9 more
openaire +5 more sources
Journal of Diabetes Investigation, 2020 There are numerous lines of clinical evidence that inhibition of the renin–angiotensin system (RAS) can prevent and delay the development of diabetes.
Yeoree Yang +4 more
doaj +1 more source