Results 31 to 40 of about 4,592,636 (274)

Organ-, inflammation- and cancer specific transcriptional fingerprints of pancreatic and hepatic stellate cells

Molecular Cancer, 2010
Background Tissue fibrosis is an integral component of chronic inflammatory (liver and pancreas) diseases and pancreatic cancer. Activated pancreatic- (PSC) and hepatic- (HSC) stellate cells play a key role in fibrogenesis. To identify organ- and disease-
Huber Peter E, Debus Jürgen, Ansorge Wilhelm, Giese Nathalia A, Wirkner Ute, Jiang Xiaohua, Samkharadze Tamar, Schwager Christian, Pan Zheng, Weis Nadine, Erkan Mert, Friess Helmut, Abdollahi Amir, Kleeff Jörg   +13 more
doaj   +1 more source

Apigenin inhibits pancreatic stellate cell activity in pancreatitis [PDF]

Journal of Surgical Research, 2015
Chronic pancreatitis (CP) is characterized by recurrent pancreatic injury, resulting in inflammation, necrosis, and fibrosis. There are currently no drugs limiting pancreatic fibrosis associated with CP, and there is a definite need to fill this void in patient care.Pancreatitis was induced in C57/BL6 mice using supraphysiologic doses of cerulein, and ...
Amy A. Mrazek, Laura J. Porro, Vandanajay Bhatia, Miriam Falzon, Heidi Spratt, Jia Zhou, Celia Chao, Mark R. Hellmich   +7 more
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Multimodal Treatment Eliminates Cancer Stem Cells and Leads to Long-Term Survival in Primary Human Pancreatic Cancer Tissue Xenografts. [PDF]

, 2013
Copyright: 2013 Hermann et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
Tunici, P, Stephan A. Hahn (423002), Hidalgo Manuel, Annette Bakker (109705), Trabulo Sara M., Hermann, PC, Hahn, SA, Patrizia Tunici (109691), Patrick C. Hermann, Hahn Stephan A., Vandana, M, Sanjeeb K. Sahoo (176483), Sahoo Sanjeeb K., Sainz, B, Sainz Bruno, Anamaria Balic (423000), Garcia Elena, Tunici Patrizia, Manuel Hidalgo, Balic, A, Balic Anamaria, Stephan A. Hahn, Vandana Mallaredy, Elena Garcia (423001), Stephan A Hahn, Christopher Heeschen (373899), Sahoo, SK, Patrizia Tunici, Bakker Annette, Mallaredy Vandana, Heeschen Christopher, Patrick C Hermann, Bruno Sainz, Sara M Trabulo, Sara M. Trabulo, Christopher Heeschen, Patrick C. Hermann (422997), Garcia, E, Mallaredy Vandana (423003), Elena Garcia, Sanjeeb K Sahoo, Heeschen, C, Manuel Hidalgo (7235), Bakker, A, Bruno Sainz Jr (422999), Sanjeeb K. Sahoo, Hermann Patrick C., Sara M. Trabulo (422998), Trabulo, SM, Anamaria Balic, Hidalgo, M, Annette Bakker   +51 more
core   +2 more sources

What are the macrophages and stellate cells doing in pancreatic adenocarcinoma?

Frontiers in Physiology, 2015
Pancreatic ductal adenocarcinoma is a devastating disease characterized by a dense desmoplastic stroma. Chemo- and radio-therapeutic strategies based on targeting cancer cells have failed in improving the outcome of this cancer suggesting important roles
Stephen J Pandol, Mouad eEdderkaoui
doaj   +1 more source

SARS-CoV-2 S Protein Subunit 1 Elicits Ca2+ Influx – Dependent Ca2+ Signals in Pancreatic Stellate Cells and Macrophages In Situ

Function, 2022
The S protein subunit 1 (S1) of SARS-CoV-2 is known to be responsible for the binding of the virus to host cell receptors, but the initial intracellular signalling steps following receptor activation of cells in the exocrine pancreas are unknown.
Julia V Gerasimenko, Ole H Petersen, Oleg V Gerasimenko   +2 more
doaj   +1 more source

The pancreatic stellate cell: a star on the rise in pancreatic diseases [PDF]

Journal of Clinical Investigation, 2007
Pancreatic stellate cells (PaSCs) are myofibroblast-like cells found in the areas of the pancreas that have exocrine function. PaSCs are regulated by autocrine and paracrine stimuli and share many features with their hepatic counterparts, studies of which have helped further our understanding of PaSC biology.
M Bishr, Omary, Aurelia, Lugea, Anson W, Lowe, Stephen J, Pandol   +3 more
openaire   +2 more sources

Piezo1-mediated stellate cell activation causes pressure-induced pancreatic fibrosis in mice

JCI Insight, 2022
Pancreatic fibrosis is a complication of chronic pancreatitis and is a prominent feature of pancreatic cancer. Pancreatic fibrosis is commonly observed in patients with prolonged pancreatic duct obstruction, which elevates intrapancreatic pressure.
Sandip M. Swain, Joelle M-J Romac, Steven R. Vigna, Rodger A. Liddle   +3 more
doaj   +1 more source

Immune Cell Modulation of the Extracellular Matrix Contributes to the Pathogenesis of Pancreatic Cancer

Biomolecules, 2021
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with a five-year survival rate of only 9%. PDAC is characterized by a dense, fibrotic stroma composed of extracellular matrix (ECM) proteins.
Ramiz S. Ahmad, Timothy D. Eubank, Slawomir Lukomski, Brian A. Boone   +3 more
doaj   +1 more source

TRPM7 Modulates Human Pancreatic Stellate Cell Activation

Cells, 2022
Pancreatic diseases, such as pancreatitis or pancreatic ductal adenocarcinoma, are characterized by the presence of activated pancreatic stellate cells (PSCs).
Julie Auwercx, Philippe Kischel, Thibaut Lefebvre, Nicolas Jonckheere, Alison Vanlaeys, Stéphanie Guénin, Silviya Radoslavova, Isabelle Van Seuningen, Halima Ouadid-Ahidouch, Hemant M. Kocher, Isabelle Dhennin-Duthille, Mathieu Gautier   +11 more
doaj   +1 more source

Pancreatic stellate cells induce angiogenesis

Suizo, 2008
膵星細胞は慢性膵炎や膵癌の際の線維化形成に中心的役割を果たす．最近，膵星細胞の多彩な細胞機能が明らかとなっている．今回，膵星細胞の血管新生誘導能について検討した．膵癌切除膵組織よりヒト膵星細胞を分離した．膵星細胞培養上清（CM）を作成し，ヒト臍静脈血管内皮細胞の増殖，遊走，細胞内シグナル伝達系に与える影響を検討した．更に，3次元管腔構造形成（in vitro血管新生能）ならびにヌードマウスの皮下でのin vivo血管新生誘導能についても検討した．CMは血管内皮細胞の増殖と遊走を刺激した．CMはERK系ならびにAkt系を活性化し，CMによる増殖ならびに遊走誘導は，これらのシグナル伝達系の抑制剤であるU0126およびwortmanninにより抑制された．CMは，in vitroおよびin ...
MASAMUNE, Atsushi, KIKUTA, Kazuhiro, WATANABE, Takashi, SATOH, Kennichi, SHIMOSEGAWA, Tooru   +4 more
openaire   +3 more sources