Results 51 to 60 of about 70,274 (304)
Fibrogenic signalling in hepatic stellate cells
Journal of Hepatology, 2010 (1) Upon liver damage, hepatic stellate cells undergo a process defined as activation (Fig. 1), that enables them to acquire a myofibroblastic phenotype. The biological actions of myofibroblasts are pivotal for liver tissue repair and fibrogenesis [1]. (2) Activation of TGFb-dependent fibrogenic signalling in hepatic stellate cells.
D.A. Mann, MARRA, FABIO
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Hepatic stellate cells: central modulators of hepatic carcinogenesis [PDF]
BMC Gastroenterology, 2015 Hepatocellular carcinoma (HCC) represents the second most common cause of cancer-related death worldwide, and is increasing in incidence. Currently, our therapeutic repertoire for the treatment of HCC is severely limited, and therefore effective new therapies are urgently required.
Thompson, Alexandra I +2 more
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Clinical Course and Impact of Breaks in Therapy for Children With Relapsed/Refractory Solid Tumors
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction Pediatric relapsed or refractory (R/R) solid tumors carry a dismal prognosis, and postrelapse patient experiences are not well described. We present postrelapse outcomes, including number of R/R events and subsequent therapy regimens.
Matthew T. McEvoy +5 more
wiley +1 more source
Cellular Physiology and Biochemistry, 2016 Background/Aims: Nonalcoholic fatty liver disease (NAFLD) progression to fibrosis, cirrhosis and hepatocellular carcinoma, alters the cellular composition of this organ.
Alexandra M. Hetherington +5 more
doaj +1 more source
Novel Molecular Mechanisms in the Development of Non-Alcoholic Steatohepatitis. [PDF]
, 2016 Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease in adults and children worldwide. NAFLD has become a severe health issue and it can progress towards a more severe form of the disease, the non-alcoholic ...
Feldstein, Ariel E, Povero, Davide
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Although most malignant germ cell tumors (GCTs) are highly curable with cisplatin‐based therapy, options for patients with multiply relapsed/refractory disease remain limited. For this population, we report the first pediatric use of gemcitabine, docetaxel, melphalan, and carboplatin (GemDMC) as part of sequential cycles of high‐dose ...
Maria Frost +10 more
wiley +1 more source
Cells, 2022 Uveal melanoma (UM) is the most common primary intraocular tumor and often spreads to the liver. Intercellular communication though extracellular vesicles (EVs) plays an important role in several oncogenic processes, including metastasis, therapeutic ...
Léo Piquet +9 more
doaj +1 more source
Stellate Cells Activation and Extra-Cellular Matrix: New Targets for Therapeutic Intervention in Fibrosis [PDF]
, 2006 Hepatic stellate cells are perisinusoidal cells characterized by vitamin A containing lipid droplets and 10 nm desmin filament in their cytoplasm. In an injured liver, stellate cells were activated through two major phase i.e, initiation and perpetuation
Atmodjo, W. L. (Wahyuni)
core
M2-like macrophages in the fibrotic liver protect mice against lethal insults through conferring apoptosis resistance to hepatocytes. [PDF]
, 2017 Acute injury in the setting of liver fibrosis is an interesting and still unsettled issue. Most recently, several prominent studies have indicated the favourable effects of liver fibrosis against acute insults.
Bai, Li +13 more
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CD133+ hepatic stellate cells are progenitor cells
Biochemical and Biophysical Research Communications, 2007 Hepatic stellate cells (HSC) play an important role in the development of liver fibrosis. Here, we report that HSC express the stem/progenitor cell marker CD133 and exhibit properties of progenitor cells. CD133+ HSC of rats were selected by specific antibodies and magnetic cell sorting.
Kordes, Claus +6 more
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