Results 61 to 70 of about 70,274 (304)

Mitochondrial uncouplers inhibit hepatic stellate cell activation [PDF]

BMC Gastroenterology, 2012
Abstract Background Mitochondrial dysfunction participates in the progression of several pathologies. Although there is increasing evidence for a mitochondrial role in liver disease, little is known about its contribution to hepatic stellate cell (HSC) activation. In this
Guimarães, E. L., Best, Jan, Dollé, L., Najimi, M., Sokal, E., van Grunsven, L. A.   +5 more
openaire   +6 more sources

Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy

Advanced Functional Materials, EarlyView.
FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao, Yejing Zhu, Hengchao Yu, Jun Zhu, Bo Wang, Yu Qiao, Zhimin Tian, Junlong Zhao, Lei Liu   +8 more
wiley   +1 more source

Mechanism of acacetin regulating hepatic stellate cell apoptosis based on network pharmacology and experimental verification

Heliyon
Background: Hepatic fibrosis is caused by various liver diseases and eventually develops into liver cancer. There is no specific drug approved for the treatment of hepatic fibrosis in the world.
Xue Hu, Haotian Shen, Rong Liu, Bin Tang, Fengmei Deng   +4 more
doaj   +1 more source

An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro

Journal of Lipid Research, 2000
Hepatocytes and hepatic stellate cells play important roles in retinoid storage and metabolism. Hepatocytes process postprandial retinyl esters and are responsible for secretion of retinol bound to retinol-binding protein (RBP) to maintain plasma retinol
Silke Vogel, Roseann Piantedosi, Jorge Frank, Avraham Lalazar, Don C. Rockey, Scott L. Friedman, William S. Blaner   +6 more
doaj   +1 more source

SerpinB3 promotes pro-fibrogenic responses in activated hepatic stellate cells [PDF]

, 2017
SerpinB3 is a hypoxia- and hypoxia-inducible factor-2\u3b1-dependent cystein protease inhibitor that is up-regulated in hepatocellular carcinoma and in parenchymal cells during chronic liver diseases (CLD). SerpinB3 up-regulation in CLD patients has been
Albano, Emanuele, Biasiolo, Alessandra, Bocca, Claudia, Busletta, Chiara, Cannito, Stefania, David, Ezio, Miglietta, Antonella, Morello, Elisabetta, Novo, Erica, Parola, Maurizio, Paternostro, Claudia, Plebani, Mario, Pontisso, Patrizia, Quarta, Santina, Sutti, Salvatore, Turato, Cristian, Villano, Gianmarco   +16 more
core   +3 more sources

Engineering a Sonotherapeutic RBC Membrane‐Derived Nanoparticle Platform for the Treatment of Liver Cancer

Advanced Functional Materials, EarlyView.
Herein, an RBC membrane‐derived nanoparticle (CMN‐ICG) is engineered to efficiently deliver a sonosensitizing agent, indocyanine green (ICG), for sonotherapy of hepatocellular carcinoma (HCC). CMN‐ICG exhibits excellent cytocompatibility, significantly enhances hepatocyte uptake, and produces excessive reactive oxygen species (ROS) upon ultrasound ...
Alap Ali Zahid, Aishik Chakraborty, Wei Luo, Juhi Bora, John Joseph Kelly, John Andrew Ronald, Arghya Paul   +6 more
wiley   +1 more source

Epigenetic cell fate regulation of hepatic stellate cells [PDF]

Hepatology Research, 2011
Research in the past three decades has identified key mediators and signaling mechanisms responsible for myofibroblastic transdifferentiation (MTD) of hepatic stellate cells (HSC), the pivotal event in liver fibrogenesis. Yet, fundamental understanding of the MTD from the viewpoint of cell fate or lineage regulation has been elusive.
Hidekazu, Tsukamoto, Nian-Ling, Zhu, Kinji, Asahina, Derek A, Mann, Jelena, Mann   +4 more
openaire   +2 more sources

PRELIVE: A Framework for Predicting Lipid Nanoparticles In Vivo Efficacy and Reducing Reliance on Animal Testing

Advanced Functional Materials, EarlyView.
PREdicting LNP In Vivo Efficacy (PRELIVE) framework enables the prediction of lipid nanoparticle (LNPs) organ‐specific delivery through dual modeling approaches. Composition‐based models using formulation parameters and protein corona‐based models using biological fingerprints both achieve high predictive accuracy across multiple organs.
Belal I. Hanafy, Chuan‐En Lu, Kai Liu, Audrey Gallud   +3 more
wiley   +1 more source

Microarray data and pathway analyses for primary human activated hepatic stellate cells compared to HepG2 human hepatoma cells

Data in Brief, 2017
As nonalcoholic fatty liver disease progresses to end-stage diseases, including fibrosis, cirrhosis and hepatocellular carcinoma, fibrotic activated hepatic stellate cells and cancerous epithelial cells can become abundant, changing the cellular ...
Alexandra M. Hetherington, Cynthia G. Sawyez, Nica M. Borradaile   +2 more
doaj   +1 more source

Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice. [PDF]

, 2017
Human serum amyloid P (hSAP), a member of the pentraxin family, inhibits the activation of fibrocytes in culture and inhibits experimental renal, lung, skin and cardiac fibrosis.
Bao, Xiaoli, Brenner, David A, Cong, Min, Fan, Xu, Jia, Jidong, Kisseleva, Tatiana, Liu, Tianhui, Wang, Ping, You, Hong, Zhai, Qingling, Zhang, Dong, Zhao, Weihua, Zhuang, Hui   +12 more
core   +2 more sources