Results 91 to 100 of about 69,340 (246)

Computational Study on Potentially Active Antibacterial Compounds in Secondary Metabolites of Extremophilic Microorganisms

ChemistryOpen, EarlyView.
This study employed density functional theory (DFT) and conceptual DFT (CDFT) to calculate the structures and properties of potential antibacterial compounds derived from 16‐membered lactone ring‐containing secondary metabolites of extremophiles, as well as midecamycin.
Dilong Li, Yanni Wang, Yinhuan Huang, Hui Zhou, Xiaoyun Xia, Wei Huang, Chaojie Wang   +6 more
wiley   +1 more source

Isolated liver tuberculosis

Bangabandhu Sheikh Mujib Medical University Journal, 2016
Isolated liver tuberculosis is still considered a rare condition and its atypical clinical presentation challenges the clinical acumen of the treating physician.
Ruksana Karim, Md. Mohsen Chowdhury, Arif Salam Khan   +2 more
doaj   +1 more source

Nevirapine- and efavirenz-associated hepatotoxicity under programmatic conditions in Kenya and Mozambique. [PDF]

, 2012
To describe the frequency, risk factors, and clinical signs and symptoms associated with hepatotoxicity (HT) in patients on nevirapine- or efavirenz-based antiretroviral therapy (ART), we conducted a retrospective cohort analysis of patients attending ...
Biot, M, Chu, K M, Ford, N P, Manzi, M, Rasschaert, F, Zachariah, R, Zuniga, I   +6 more
core   +2 more sources

Advancing pharmacometrics in Africa—Transition from capacity development toward job creation

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.
Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai, Samer Mouksassi, Innocent G. Asiimwe, Craig R. Rayner, Steven Kern, Phumla Sinxadi, Paolo Denti, Eric Decloedt, Catriona Waitt, Bernhards R. Ogutu, Rik de Greef   +10 more
wiley   +1 more source

A Case Report: Isolated Liver Tuberculosis

Bangabandhu Sheikh Mujib Medical University Journal, 2010
Isolated liver tuberculosis is still considered a rare condition and atypical clinical presentation challenges the clinical acumen of the treating physician.
Zulfiqur Rhaman Khan, Md Mohsen Chowdhury, Mohammad Saif Uddin, Md Abu Taher   +3 more
doaj   +1 more source

Silymarin protects liver against toxic effects of anti-tuberculosis drugs in experimental animals [PDF]

, 2008
Background The first line anti-tuberculosis drugs isoniazid (INH), rifampicin (RIF) and pyrazinamide (PZA) continues to be the effective drugs in the treatment of tuberculosis, however, the use of these drugs is associated with toxic reactions in tissues,
Sude Eminzade, Fikriye Uras, Fikret V Izzettin, S Houston, GS Timmins, D Zimhony, Hong Kong Chest Service, Medical Research Counsil, Myambutol (Lederle), A Trevor, N Vuilleumier, BU Bradford, HG Jeong, Y Dai, JA Timbrel, SA Tasduq, CP Sodhi, R Pal, C Victorrajmohan, SV Rana, S Attri, FS Hogan, P Morazzoni, MR Adhvaryu, S Santhosh, Medical Research Council, SK Sharma, AK Bahri, R Pal, SA Tasduq, CP Sodhi, SA Tasduq, SM Meeran, K Raina   +32 more
core   +1 more source

Bridging Psychological Stress and Skin Cellular Aging: Flavonoids as a Dual‐Action Therapeutic Strategy

Phytotherapy Research, EarlyView.
ABSTRACT Psychological stress (or simply “stress”) is a major contributor to chronic disease worldwide, affecting 35% of the global population, including younger generations. Furthermore, it plays a significant role in human premature aging; hence, its detrimental effects on people's health compel us to comprehend and control the ways in which ...
Marco Duarte, Sílvia Santos Pedrosa, P. Raaj Khusial, Ana Raquel Madureira   +3 more
wiley   +1 more source

Earlier versus later start of antiretroviral therapy in HIV-infected adults with tuberculosis. [PDF]

, 2011
Tuberculosis remains an important cause of death among patients infected with the human immunodeficiency virus (HIV). Robust data are lacking with regard to the timing for the initiation of antiretroviral therapy (ART) in relation to the start of ...
Anne E. Goldfeld, Bertrand Guillard, Borann Sar, Bunnet Dim, Chanroeurn Hak, Chhun Im Sin, Chindamony Kim, Claire Rekacewicz, Didier Laureillard, Eric Nerrienet, François-Xavier Blanc, Jean-François Delfraissy, Khemarin Kim Lak, Laurence Borand, Lawrence Fox, Marcelo Fernandez, Meintjes G, Narom Prak, Olivier Marcy, Sarin Chan, Sath Sun, Sirenda Vong, Spire B, Thim Sok, Wood R, Yoann Madec   +25 more
core   +3 more sources

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Primary tubercular liver abscess in an immunocompetent adult: a case report

Journal of Medical Case Reports, 2009
Introduction Isolated primary tubercular abscess is one of the rare forms of extrapulmonary tuberculosis. A greater awareness of this rare clinical entity may help in commencing specific evidence-based therapy quickly and preventing undue morbidity and ...
Baveja CP, Gumma Vidyanidhi, Chaudhary Monica, Jha Himanshu   +3 more
doaj   +1 more source