Results 121 to 130 of about 69,340 (246)

Liver toxicity associated with tuberculosis chemotherapy in the REMoxTB study

BMC Medicine, 2018
Background Drug-induced liver injury (DILI) is a common complication of tuberculosis treatment. We utilised data from the REMoxTB clinical trial to describe the incidence of predisposing factors and the natural history in patients with liver enzyme ...
Conor Duncan Tweed, Genevieve Helen Wills, Angela M. Crook, Rodney Dawson, Andreas H. Diacon, Cheryl E. Louw, Timothy D. McHugh, Carl Mendel, Sarah Meredith, Lerato Mohapi, Michael E. Murphy, Stephen Murray, Sara Murthy, Andrew J. Nunn, Patrick P. J. Phillips, Kasha Singh, M. Spigelman, S. H. Gillespie   +17 more
doaj   +1 more source

Pregnane X Receptor Regulates Human Endocrine System by Inducing Sex Hormone–Binding Globulin Expression

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 4, April 2026.
ABSTRACT Sex hormone–binding globulin (SHBG) is a sex hormone carrier. We aimed to characterize the role of pregnane X receptor (PXR), a major regulator of drug metabolism, in SHBG regulation. Serum SHBG was measured in four clinical trials (n = 61) and expression in in vitro experiments in human 3D hepatocyte spheroids and HepG2 cells.
Maria H. Ahonen, Anja Konzack, Tomas Smutny, Petr Pavek, Jukka Hakkola, Janne Hukkanen   +5 more
wiley   +1 more source

Rationale and design of a parallel randomised trial of a plant‐based intensive lifestyle intervention for diabetes remission: The REmission of diabetes using a PlAnt‐based weight loss InteRvention (REPAIR) trial

Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 2627-2641, April 2026.
Abstract Aims As type 2 diabetes (T2D) continues to rise globally and remains a major driver of cardiovascular disease, its remission has emerged as a therapeutic target. Current evidence supports bariatric surgery and low‐calorie diets with meal replacements.
Brighid McKay, Dayana El Chaar, Melanie Paquette, Michael Vallis, Diana Sherifali, Paul Oh, Susan Marzolini, Kaberi Dasgupta, Gillian Booth, Mike Lean, Hertzel C. Gerstein, Jordi Salas‐Salvadó, Jacqueline L. Beaudry, Christopher P. F. Marinangeli, Russell J. de Souza, Lawrence A. Leiter, Cyril W. C. Kendall, David J. A. Jenkins, John L. Sievenpiper, Laura Chiavaroli   +19 more
wiley   +1 more source

[Pseudotumoral hepatic tuberculosis].

Anales de medicina interna (Madrid, Spain : 1984), 1992
Liver infection as a result of tuberculosis is well known; there are several histological lesions, the most important being epithelioid cell granuloma. There are 3 anatomo-clinic variants: military or micronodular type, macronodular or pseudotumoral and pericanalicular of cholestatic.
A J, Corrales Torres, A, Fernández Martínez, D, Serrano, M T, Herranz Marín, M, Omar Mohamed, J F, Jiménez-Alonso   +5 more
openaire   +1 more source

The Dual Immunoregulatory Role of CREB3L1 Underlying Latent and Severe Tuberculosis Clinical Manifestation

Immunology, Volume 177, Issue 4, Page 810-823, April 2026.
RNA‐seq of lungs and livers from Mycobacterium tuberculosis ‐infected mice with distinct disease outcomes revealed organ‐specific responses driven by differences in immune activity and bacterial burden. Meta‐analysis identified orthologous genes shared with human latent TB and mouse liver, with Creb3l1, Myo7b, Cyyr1 and Cbs differentially expressed and
Felipe T. Lima, Ricardo C. Castro, Francisco R. Javier, Caroline Fontanari, Valdes R. Bollela, Rogerio S. Rosada, Célio L. Silva, Lúcia H. Faccioli, Luiz G. Gardinassi, Fabiani G. Frantz   +9 more
wiley   +1 more source

Quinic Acid and Synthetic Derivatives in Medicinal Chemistry

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
Quinic acid and its derivatives are gaining recognition as versatile scaffolds in drug discovery. This review explores their emerging roles in inflammation, infection, cancer, and metabolic disorders, highlighting recent advances that position them beyond chlorogenic acids as promising platforms for therapeutic innovation. Quinic acid (QA) is a natural
Iago C. Vogel, Manuel J. Verganista, Nuno R. Candeias   +2 more
wiley   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, Volume 15, Issue 10, 13 March 2026.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, Volume 13, Issue 16, 18 March 2026.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source

Prospective Open‐Label Safety Study of Edaravone Dexborneol in Filipino Patients With Acute Ischemic Stroke

Brain and Behavior, Volume 16, Issue 3, March 2026.
This prospective, single‐arm study evaluated the real‐world safety of edaravone dexborneol in Filipino patients with acute ischemic stroke treated within 48 h of symptom onset. Adverse events were predominantly mild and transient, with headache and reversible liver enzyme elevations being the most common. No treatment discontinuations, life‐threatening
Zenyros Faith Sabellano, Bonifacio Pedregosa II, Laurence Kristoffer Batino, Jose Navarro   +3 more
wiley   +1 more source

Propolis‐Based Hybrid Nanoflowers as Multifunctional Nanozymes: Structural Integration of Polyphenols for Enhanced Catalytic and Antioxidant Activity

Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.
ABSTRACT Propolis is a polyphenol‐rich natural resin with well‐documented antioxidant activity; however, its practical application is restricted by poor aqueous solubility and limited stability. Herein, propolis‐based organic–inorganic hybrid nanoflowers (Prp‐Nfs) were synthesized by integrating a propolis extract into a Cu3(PO4)2·3H2O matrix under ...
Cevahir Altinkaynak, Fatih Kirmizikar
wiley   +1 more source