Results 231 to 240 of about 1,894,434 (309)

A PEGylated nanobody against HBsAg exhibits pleiotropic antiviral efficacy in hepatitis B models. [PDF]

J Nanobiotechnology
Yang Q, Liu W, Huang M, Lin M, Hu J, Wei J, Yang Q, Wang S, Wang D, Huang A, Cai X.   +10 more
europepmc   +1 more source

Tofacitinib Regulates β‐Catenin Nuclear Translocation to Inhibit FLS Migration and Alleviate Clinical Symptoms of RA

iNew Medicine, EarlyView.
ABSTRACT Objective Tofacitinib is a Janus kinase (JAK) inhibitor approved for the treatment of moderate‐to‐severe rheumatoid arthritis (RA). However, its synovium‐related molecular mechanisms, particularly its regulatory effect on fibroblast‐like synoviocyte (FLS) migration, remain incompletely understood.
Shuqi Fang, Tianjing Zhang, Ling Hu, Ruijin Liu, Leyi Jia, Menglin Bai, Jiale Dong, Yuchen Zhao, Han Wang, Lei Zhang, Tao Li, Youcai Deng, Xianzheng Zhang, Lingling Zhang   +13 more
wiley   +1 more source

Integrated one‐pot CRISPR‐Cas detection: Addressing strategies and future prospects

Interdisciplinary Medicine, EarlyView.
Integrated one‐pot CRISPR‐Cas detection significantly simplifies workflows, reduces cross‐contamination risks, and shortens turnaround times, making it highly suitable for point‐of‐care testing (POCT) and resource‐limited settings. Key challenges include system compatibility issues between Cas proteins and isothermal amplification, limited multiplexing
Jian Zhou, Xuemei Ren, Yingjie Ren, Ruiping Wu, Ruiman Geng, Le Chen, Zhuo Li   +6 more
wiley   +1 more source

Evaluation of mosquito transmission of equine hepacivirus in laboratory and field studies. [PDF]

J Med Entomol
Magalhaes T, Carvalho Leandro D, Ozel E, Liang X, Lyons B, Scheel TKH, Salomon J, Luethy D, Kaufman PE, Tomlinson JE.   +9 more
europepmc   +1 more source

Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li, Han Li, Bojie Chen, Ling Jiang, Keyu Long, Jiaqi Lang, Xingxiang Pu, Erhu Xiong   +7 more
wiley   +1 more source

Genetic Heterogeneity of Hepatitis E Virus (HEV) in Wild Boars in Italy. [PDF]

Animals (Basel)
Sarchese V, Di Profio F, Carnevale M, Battistini R, Moroni B, Guardone L, Robetto S, Orusa R, Marsilio F, Martella V, Di Martino B.   +10 more
europepmc   +1 more source

Organ‐Specific Human Microbiomes and Dysbiosis: Mechanistic Links to Disease and Emerging Therapeutic Strategies

Journal of Clinical Laboratory Analysis, EarlyView.
Schematic overview of the human microbiome and major microbiota‐derived metabolites across body sites, highlighting the gut–brain, gut–heart, and gut–kidney axes in host physiology and disease. ABSTRACT Background The human microbiome is a dynamic and diverse community of microorganisms that affects susceptibility to illness and promotes wellness ...
Awadh Alanazi
wiley   +1 more source

Platelet-derived S100A9 contributes to endotheliopathy in alcohol-associated hepatitis. [PDF]

JCI Insight
Kirlin F, Fattahi N, Garcia-Milian R, Collin F, Wang W, Kim Y, Lucien F, Sun Z, Lam TT, Hwa J, Iwakiri Y, McConnell MJ.   +11 more
europepmc   +1 more source

Time‐ and Temperature‐Dependent Response of Acquired FV Inhibitors: Implications for Laboratory Diagnosis and Clinical Management

Journal of Clinical Laboratory Analysis, EarlyView.
This in vitro workflow illustrates the time‐and temperature‐dependent behavior of acquired FV inhibitors. Patient plasma was centrifuged and serially diluted, followed by parallel incubation at room temperature and 37°C. Serial measurements of APTT mixing test and residual FV activity were recorded across incubation time points to monitor inhibitor ...
Lihua Zhang, Mingjie Li, Zhiqiang Xie, Junxiang Yao, Yingping Cao, Lihui Chen, Meihua Wang   +6 more
wiley   +1 more source

Outbreak of FAdV-4 infection in blue-breasted quail (Excalfactoria chinensis) reveals novel cross-species transmission of virus in domestic poultry and ornamental pet birds. [PDF]

Poult Sci
Teng M, Chai YX, Luo Q, Peng ZF, Zheng LP, Jin QY, Luo J.   +6 more
europepmc   +1 more source