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Nature Reviews Disease Primers, 2018
Autoimmune hepatitis (AIH) is a severe liver disease that affects children and adults worldwide. The diagnosis of AIH relies on increased serum transaminase and immunoglobulin G levels, presence of autoantibodies and interface hepatitis on liver histology.
Giorgina, Mieli-Vergani +7 more
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Autoimmune hepatitis (AIH) is a severe liver disease that affects children and adults worldwide. The diagnosis of AIH relies on increased serum transaminase and immunoglobulin G levels, presence of autoantibodies and interface hepatitis on liver histology.
Giorgina, Mieli-Vergani +7 more
openaire +4 more sources
The Indian Journal of Pediatrics, 2001
Autoimmune hepatitis is one of the causes of chronic progressive liver disease in childhood. Here we report 14 cases with clinical findings, therapeutic management and prognosis, in order to define the course of the disease. Diagnosis of autoimmune hepatitis was done with the presence of at least one of these autoantibodies; antinuclear antibody ...
H, Ozen +4 more
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Autoimmune hepatitis is one of the causes of chronic progressive liver disease in childhood. Here we report 14 cases with clinical findings, therapeutic management and prognosis, in order to define the course of the disease. Diagnosis of autoimmune hepatitis was done with the presence of at least one of these autoantibodies; antinuclear antibody ...
H, Ozen +4 more
openaire +2 more sources
Orvosi Hetilap, 2007
First the short history of the disease, then its etiopathogenesis, the role of genetic, environmental and immunologic factors are described. In the second part, the questions of diagnosis, differential diagnosis and the immunosuppressive treatment, with new therapeutic modalities and liver transplantation are discussed.
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First the short history of the disease, then its etiopathogenesis, the role of genetic, environmental and immunologic factors are described. In the second part, the questions of diagnosis, differential diagnosis and the immunosuppressive treatment, with new therapeutic modalities and liver transplantation are discussed.
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The Indian Journal of Pediatrics, 1995
Autoimmune hepatitis can present as either acute or chronic disease in children. Clinical and laboratory features, including association with extrahepatic autoimmune syndromes and prompt response to immunosuppressive treatment, circulating autoantibodies and hypergammaglobulinemia, suggest an immune etiology.
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Autoimmune hepatitis can present as either acute or chronic disease in children. Clinical and laboratory features, including association with extrahepatic autoimmune syndromes and prompt response to immunosuppressive treatment, circulating autoantibodies and hypergammaglobulinemia, suggest an immune etiology.
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Digestion, 1986
A previously well young woman presented with an acute hepatitis resembling viral hepatitis and a liver biopsy after 5 weeks showed features of acute hepatitis. Infection with identifiable viruses or other organisms known to cause hepatitis was excluded. Evidence for autoimmune chronic active hepatitis ab initio included prolonged fever, lymphadenopathy,
Crapper, RM +3 more
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A previously well young woman presented with an acute hepatitis resembling viral hepatitis and a liver biopsy after 5 weeks showed features of acute hepatitis. Infection with identifiable viruses or other organisms known to cause hepatitis was excluded. Evidence for autoimmune chronic active hepatitis ab initio included prolonged fever, lymphadenopathy,
Crapper, RM +3 more
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Autoimmune hepatitis: Current knowledge
Clinics and Research in Hepatology and Gastroenterology, 2012Autoimmune hepatitis in children is of type 1, with antinuclear or anti-smooth muscle antibodies, more frequent in teenage girls, or of type 2, with anti-liver-kidney microsomes 1 and/or anti-liver cytosol 1 antibodies, in younger children. Other autoimmune diseases may be present in the patient or his relatives.
VAJRO, Pietro, Giulia Paolella
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Best Practice & Research Clinical Gastroenterology, 2003
M P, Manns, C P, Strassburg
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M P, Manns, C P, Strassburg
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2011
Abstract Autoimmune hepatitis is a self-perpetuating inflammation of the liver of unknown cause that is associated with autoantibodies, hypergammaglobulinemia, and interface hepatitis seen on histologic examination. Autoimmune hepatitis afflicts 100,000 to 200,000 persons in the United States annually and accounts for 5.9% of liver ...
Kymberly D. Watt, Albert J. Czaja
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Abstract Autoimmune hepatitis is a self-perpetuating inflammation of the liver of unknown cause that is associated with autoantibodies, hypergammaglobulinemia, and interface hepatitis seen on histologic examination. Autoimmune hepatitis afflicts 100,000 to 200,000 persons in the United States annually and accounts for 5.9% of liver ...
Kymberly D. Watt, Albert J. Czaja
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The American Journal of the Medical Sciences
Despite tacrolimus (TAC) or mycophenolate mofetil (MMF) for alternate approaches, a proportion of patients still required further exploration of other therapeutic options due to uncontrolled autoimmune hepatitis(AIH). The role of cyclophosphamide (CYC) for AIH has been explored in isolated case reports and small series.
AnJi, Xiong +3 more
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Despite tacrolimus (TAC) or mycophenolate mofetil (MMF) for alternate approaches, a proportion of patients still required further exploration of other therapeutic options due to uncontrolled autoimmune hepatitis(AIH). The role of cyclophosphamide (CYC) for AIH has been explored in isolated case reports and small series.
AnJi, Xiong +3 more
openaire +2 more sources