Results 61 to 70 of about 164,357 (279)

p16Ink4a‐Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway

Advanced Science, EarlyView.
This study found that, following the long‐term CCl4 treatment, p16high hepatocytes appeared in zone 3, spatially co‐localizing with fibrotic areas. A specific cluster of p16high hepatocytes upregulated CTF1/LIF expression which induced HSC activation and further liver fibrosis, as revealed by single cell transcriptomic analysis.
Koji Nishikawa, Teh‐Wei Wang, Satoshi Kawakami, Shota Tanimoto, Kiyoshi Yamaguchi, Taketomo Kido, Masamichi Kimura, Tsunekazu Hishima, Yuki T. Okamura, Satotaka Omori, Takumi Iritani, Toshikaze Chiba, Takehiro Jimbo, Michio Katano, Kansuporn Kamataki, Ryoichi Yokoyama, Eigo Shimizu, Kiminori Kimura, Satoshi Yamzaki, Seiya Imoto, Yoichi Furukawa, Atsushi Miyajima, Yoshikazu Johmura, Makoto Nakanishi   +23 more
wiley   +1 more source

Sialendoscopic management of autoimmune sialadenitis: a review of literature [PDF]

, 2017
Autoimmune diseases of major salivary glands include Sjögren's syndrome and a complex of disorders classified as immunoglobulin G4-related diseases.
DE VINCENTIIS, Marco, DE VIRGILIO, Armando, Fusconi, Massimo, Gallo, Andrea, Greco, Antonio, Martellucci, Salvatore, Pagliuca, Giulio   +6 more
core   +2 more sources

Grand round: Autoimmune hepatitis [PDF]

Journal of Hepatology, 2019
Autoimmune hepatitis is a corticosteroid-responsive liver disease arising consequent to immunogenetic and environmental risk factors. The clinical course reflects relapsing and remitting, hepatocyte targeted immunologic damage, which is countered by reparative responses to cell injury. Appropriate and timely immunosuppressive therapy drives the disease
Palak J. Trivedi, Stefan G. Hubscher, Michael Heneghan, Dermot Gleeson, Gideon M. Hirschfield   +4 more
openaire   +5 more sources

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

Liver transplantation for alcoholic cirrhosis: Long term follow-up and impact of disease recurrence [PDF]

, 2001
Background. Alcoholic liver disease has emerged as a leading indication for hepatic transplantation, although it is a controversial use of resources. We aimed to examine all aspects of liver transplantation associated with alcohol abuse.
Andrea M. DiMartini, Anthony J. Demetris, Ashok Jain, Balan, Bassendine, Becker, Belle, Bellentani, Beresford, Beresford, Beresford, Berlakovich, Bernard, Bizollon, Blakolmer, Campbell, Chao, Christopher O.C. Bellamy, Conjeevaram, Cromie, Duvoux, Enomoto, Everhart, Everson, Fauerholdt, Ferrell, Forrest Dodson, Foster, Gane, Graziadei, Harrison, Hoofnagle, Howard, Iezzoni, Ishak, Jain, John J. Fung, Keeffe, Kenngott, Kris Ruppert, Kumar, Kyriacou, Lee, Levin, Levy, Lucey, Lucey, Lucey, Mendenhall, Michael Torbenson, Nabel, Neuberger, Neuberger, Neuberger, Osorio, Pageaux, Pappo, Pereira, Reed, Reich, Saunders, Schiff, Seitz, Sherlock, Shev, Starzl, Tang, Thomas E. Starzl, Tringali, Uchimura, Wiesner, Yates   +71 more
core   +2 more sources

Classical autoimmune hepatitis and the IgG4-associated autoimmune hepatitis in paediatric patients

Polish Journal of Pathology
The IgG4-associated autoimmune hepatitis (IgG4-AIH) is a newly proposed disease entity characterised by the accumulation of the IgG4-expressing plasma cells in the liver. Its pathophysiology and clinical significance remain unclear and have poor evidence
Dominika Kaps-Kopiec, Małgorzata Woźniak, Dorota Jarzębicka, Renata Grzywa-Czuba, Joanna Pawłowska, Piotr Czubkowski, Joanna Cielecka-Kuszyk   +6 more
doaj   +1 more source

Drug-induced hepatitis superimposed on the presence of anti-SLA antibody: a case report

Journal of Medical Case Reports, 2008
Introduction Autoimmune hepatitis is a necroinflammatory disorder of unknown etiology characterized by the presence of circulating antibodies, hypergammaglobulinemia, and response to immunosuppression.
Etxagibel Aitziber, Julià M Rosa, Brotons Alvaro, Company M Margarita, Dolz Carlos   +4 more
doaj   +1 more source

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

Clinical characteristics and outcome of patients with autoimmune hemolytic anemia (AIHA) uniformly defined as primary by a diagnostic work-up [PDF]

, 2016
Primary autoimmune hemolytic anemia (P-AIHA) is a relatively uncommon and hetereogeneous disease characterized by the destruction of red blood cells due to anti-erythrocyte autoantibodies (AeAbs) in the absence of an associated disease [1–3].
ARMIENTO, DANIELE, CARONNA, Roberto, COLAFIGLI, GIOIA, Coluzzi, S, De Propris, Ms, FERRETTI, ANTONIETTA, FOA, Roberto, GIOVANNETTI, GIANLUCA, GIRELLI, Gabriella, GUARINI, Anna, LA ROCCA, URSULA, MAURO, Francesca Romana, MOLICA, MATTEO, Morano, G, Paoloni, F, Trastulli, F   +15 more
core   +1 more source

Infliximab‐induced autoimmune hepatitis requiring liver transplantation

Clinical Case Reports, 2019
Autoimmune hepatitis is an infrequent but significant side effect of infliximab treatment. Diagnosis of autoimmune hepatitis is based on clinical, laboratory, and histological findings.
Frederick Wong, Bashaar Al Ibrahim, Joanna Walsh, Karim Qumosani   +3 more
doaj   +1 more source