Results 261 to 270 of about 102,448 (310)

Cell Culture Models and Animal Models of Viral Hepatitis. Part II: Hepatitis C

Lab Animal, 2005
The lack of a preventive vaccine, coupled with common unresponsiveness to treatment and coinfection with HIV, has made HCV a major threat to public health. The authors review in vitro and in vivo models that are being used to study HCV and to develop new treatments and preventive measures.
Chandan, Guha, Sung-W, Lee, Namita Roy, Chowdhury, Jayanta Roy, Chowdhury   +3 more
openaire   +2 more sources

High seroprevalence of viral hepatitis among animal handlers in Abeokuta, Ogun State, Nigeria

Journal of Immunoassay and Immunochemistry, 2020
Viral hepatitis is a deadly disease which can manifest as acute, chronic, hepatocellular carcinoma, and liver failure. Information about hepatitis is scarce among animal handlers. Due to Federal Government of Nigeria diversification programmes, many people are now involved in animal farming which can make them susceptible to viral hepatitis. This study
A S, Oluremi, T A, Ajadi, O O, Opaleye, O A T, Alli, D O, Ogbolu, S S, Enitan, O O, Alaka, A A, Adelakun, I O, Adediji, A O, Ogunleke, I E, Suleiman, E A, Olowoyeye, O O, Adewumi, A T, Ojo, O O, Adeyeye-Adetunji, S S, Hammed   +15 more
openaire   +2 more sources

Serologic and animal inoculation studies of a communal outbreak of viral hepatitis, type A

The American Journal Of The Medical Sciences, 1977
Sera from individuals in an outbreak of viral hepatitis in a multifamily household, probably spread by contaminated food, were studied for antibodies to hepatitis A virus (anti-HAV), and selected acute phase sera were inoculated into marmosets. Significant rises in anti-HAV titers between acute and convalescent sera occurred in all of 15 individuals in
L F, Barker, J L, Dienstag, D E, Lorenz, R H, Purcell, D C, Wong, S M, Feinstone, M R, Peterson, M W, Rosen   +7 more
openaire   +2 more sources

Cell culture and animal models for human viral hepatitis

Hepatology Research, 2004
Abstract Human hepatitis viruses are currently the subjects of intense investigation because of the tremendous clinical impact of these agents on human health. For other viral infections, cell culture and animal models have played crucial roles in the development of vaccines and drug therapies as well as characterization of viral life cycles. However,
openaire   +1 more source

Hepatitis B treatment: rational combination chemotherapy based on viral kinetic and animal model studies

Antiviral Research, 2002
Hepatitis B virus (HBV) causes a generally non-cytopathic infection in the liver. Even though HBV is a DNA virus, it replicates via reverse transcription which is coordinated within the viral nucleocapsid by the virus-specific polymerase. The major transcriptional template is the viral mimichromosome from which the viral DNA exists as a covalently ...
Lewin, S, Walters, T, Locarnini, S
openaire   +5 more sources

Pathogenic molecular mechanisms in an animal model of fulminant hepatic failure: Rabbit hemorrhagic viral disease

Journal of Laboratory and Clinical Medicine, 2004
In this study we sought to determine whether molecular mechanisms involved in the pathogenesis of fulminant hepatic failure are present in rabbits experimentally infected with rabbit hemorrhagic disease virus (RHDV). The activities of aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase, as well as bilirubin concentration ...
Sonia, Sánchez-Campos, Marcelino, Alvarez, Jesus M, Culebras, Javier, Gonzalez-Gallego, Maria J, Tuñón   +4 more
openaire   +2 more sources

Viral hepatitis: The bumpy road to animal models for HBV infection.

Nature reviews. Gastroenterology & hepatology, 2017
Cell culture infection models help to develop antiviral agents, but animal models are required to understand complex virus-host interactions and the development of immune therapies. Although identification of the HBV uptake receptor enabled establishing cell lines that replicate HBV from its natural transcription template, animal models supporting the ...
openaire   +3 more sources

PD-1 blockage reverses immune dysfunction and hepatitis B viral persistence in a mouse animal model (105.23)

The Journal of Immunology, 2012
Abstract Persistent hepatitis B viral (HBV) infection results in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). Recent studies in animal models of viral infection indicate that the interaction between the inhibitory receptor, programmed death (PD)-1, on lymphocytes and its ligand (PD-L1) play a critical role in T-
HorngTay Tzeng, PeiJer Chen, PingNing Hsu   +2 more
openaire   +1 more source

A mouse with humanized liver as an animal model for predicting drug effects and for studying hepatic viral infection: where to next?

Expert Opinion on Drug Metabolism & Toxicology, 2013
The mouse is a common model used in evaluating drug metabolism and hepatitis infectivity. However, these models have limited value due to species difference in hepatic functions, leading to the creation of the chimeric mouse 12 years ago. These models were unique in that their hepatocytes had been replaced with human (hu) hepatocytes (dubbed the 'first-
Katsutoshi, Yoshizato, Chise, Tateno
openaire   +2 more sources

Expression of hepatitis B viral antigens in animal cells transfected with viral DNA.

Transactions of the Association of American Physicians, 1983
Mouse L cells deficient in thymidine kinase (tk-) were transfected with either monomeric or dimeric circular HBV DNA and co-transformed with tk+ DNA derived from herpes simplex virus. Thymidine kinase transformed cell colonies were harvested and maintained as separate cell lines.
S Z, Hirschman, E, Garfinkel, S, Sugrue
openaire   +1 more source