Results 241 to 250 of about 102,448 (310)

MiR‐375 in CAFs‐Derived EVs Promotes HCC Progression via Regulating RASA1 and May Potentially Serve as a Biomarker for HCC

Cancer Science, EarlyView.
CAFs could transfer EVs miR‐375 into endothelial cells with a low level of RASA1 and further promote EC angiogenesis. Plasma EVs miR‐375 have the potential values as a novel diagnostic and prognostic biomarker for HCC. ABSTRACT Cancer‐associated fibroblasts (CAFs) in the tumor microenvironment play an important role in cancer initiation and progression
Wei Qin, Li Wang, Beiyuan Hu, Cuicui Xiao, XiaoYing Wu, Huan Tian, Songlin Peng   +6 more
wiley   +1 more source

<i>Lacticaseibacillus rhamnosus</i> CRL1505 Ameliorates Liver Injury and Inflammation in Poly(I:C)-Induced Acute Hepatitis. [PDF]

Foods
Lorenzo Pisarello MJ, Baillo AA, Elean M, Albarracín L, Arellano-Arriagada L, Suda Y, Kitazawa H, Villena J.   +7 more
europepmc   +1 more source

TREM2 in Macrophages Promotes Renal Fibrosis via Activation of β‐Catenin Signalling Pathway in Obstructive Nephropathy

Cell Proliferation, EarlyView.
Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) promotes obstructive nephropathy progression by activating the β‐catenin signalling pathway, driving M2 macrophage polarisation, migration and fibrogenic gene expression. targeted inhibition of TREM2 thus represents a promising novel strategy against renal fibrosis.
Jia Wei, Zixia Li, Gengyu Du, Ting Chen, Min Yang, Zhen Yuan, Yidan Zheng, Xiang Yan   +7 more
wiley   +1 more source

Investigation of Changes in Irisin and Nesfatin-1 Levels in Chronic Viral Hepatitis. [PDF]

J Clin Med
Senol FF, Bahcecı I, Algül S, Aytac O, Şenol A, Çelik Y.   +5 more
europepmc   +1 more source

Single Cell Multi‐Omics Revealing the Important Role of MR1 Mediated MAIT Cells in Maintaining Rejection for Liver Transplantation

Cell Proliferation, EarlyView.
This multi‐omics study reveals the significant role of MAIT cells in liver transplant rejection. MAIT cells drive rejection in liver transplantation via the MR1 axis. Their absence reshapes T cell responses and clonal expansion, attenuating allograft injury.
Hailun Cai, Xinqiang Li, Xin Zhou, Xueteng Wang, Zhuoyu Jia, Ruidong Ding, Yurong Luo, Ye Wang, Shipeng Li, Wenxing Sun, Dongxing Wu, Dahong Teng, Kai Zhao, Guanghui Pei, Jinzhen Cai, Bin Wu   +15 more
wiley   +1 more source

Molecular insights into domestic cat hepatitis B virus linking genome to function. [PDF]

Vet Res Commun
Šolaja S, Milićević V, Glišić D, Radalj A, Đurić M, Knežević A, Nišavić J.   +6 more
europepmc   +1 more source

Targeting Egfr‐Mediated Cell Proliferation and Lipid Metabolism Separation Effectively Accelerate Liver Regeneration

Cell Proliferation, EarlyView.
AREG coordinates cell proliferation and lipid metabolism reprogramming during liver regeneration and targeting lipid metabolism can promote liver regeneration. ABSTRACT Hepatocyte proliferation restores liver mass after partial hepatectomy (PHx), but the metabolic cost of this process remains unclear.
Yuelei Hu, Shifei Song, Ruilin Wang, Ni An, Jinmei Diao, Yuguo Chen, Juan Liu, Guoyue Lv   +7 more
wiley   +1 more source

Engineered virus-hunter vaccine overcomes HBV immune tolerance. [PDF]

Gut
Chen X, Liu X, Xu T, Wang Y, Wang P, Liu H, Jiang Y, Qin X, Zhang L, Xiong Y, Ding J, Chen Y, Chen F, Ning W, Zeng H, Yang S, Xu L, Zhang T, Yuan Q, Liu C, Luo W, Xia N.   +21 more
europepmc   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Phosphoinositide kinase PIKfyve inhibitor apilimod blocks hepatitis E virus infection. [PDF]

eGastroenterology
Ring JJ, Schlienkamp S, Goussain Darido ML, Zhang X, Pinto Veiga O, Haase JA, Richter E, Gömer A, Fu RM, Dao Thi VL, Ulrich RG, Klöhn M, Todt D, Bader V, Winklhofer KF, Kinast V, Neyts J, Kaptein SJF, Steinmann E, Brüggemann Y.   +19 more
europepmc   +1 more source