Results 221 to 230 of about 104,518 (264)
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Viral hepatitis: The bumpy road to animal models for HBV infection.
Nature reviews. Gastroenterology & hepatology, 2017Cell culture infection models help to develop antiviral agents, but animal models are required to understand complex virus-host interactions and the development of immune therapies. Although identification of the HBV uptake receptor enabled establishing cell lines that replicate HBV from its natural transcription template, animal models supporting the ...
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The Journal of Immunology, 2012
Abstract Persistent hepatitis B viral (HBV) infection results in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). Recent studies in animal models of viral infection indicate that the interaction between the inhibitory receptor, programmed death (PD)-1, on lymphocytes and its ligand (PD-L1) play a critical role in T-
HorngTay Tzeng +2 more
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Abstract Persistent hepatitis B viral (HBV) infection results in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). Recent studies in animal models of viral infection indicate that the interaction between the inhibitory receptor, programmed death (PD)-1, on lymphocytes and its ligand (PD-L1) play a critical role in T-
HorngTay Tzeng +2 more
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Expert Opinion on Drug Metabolism & Toxicology, 2013
The mouse is a common model used in evaluating drug metabolism and hepatitis infectivity. However, these models have limited value due to species difference in hepatic functions, leading to the creation of the chimeric mouse 12 years ago. These models were unique in that their hepatocytes had been replaced with human (hu) hepatocytes (dubbed the 'first-
Katsutoshi, Yoshizato, Chise, Tateno
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The mouse is a common model used in evaluating drug metabolism and hepatitis infectivity. However, these models have limited value due to species difference in hepatic functions, leading to the creation of the chimeric mouse 12 years ago. These models were unique in that their hepatocytes had been replaced with human (hu) hepatocytes (dubbed the 'first-
Katsutoshi, Yoshizato, Chise, Tateno
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Lessons from the Pathology of Viral Hepatitis in Animal Models
1986The histogenesis of the various morphologic features in the different types of human viral hepatitis is not established, nor are definite criteria in the histologic distinction agreed upon. Moreover, the mechanism of transition to hepatocellular carcinoma (HCC) is not clarified, including molecular pathobiologic changes.
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Expression of hepatitis B viral antigens in animal cells transfected with viral DNA.
Transactions of the Association of American Physicians, 1983Mouse L cells deficient in thymidine kinase (tk-) were transfected with either monomeric or dimeric circular HBV DNA and co-transformed with tk+ DNA derived from herpes simplex virus. Thymidine kinase transformed cell colonies were harvested and maintained as separate cell lines.
S Z, Hirschman, E, Garfinkel, S, Sugrue
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The Journal of Immunology, 2011
Abstract Recent studies in animal models of virus infection, indicate that the interaction between the inhibitory receptor programmed death (PD)-1 on lymphocytes and its ligands plays a critical role in T-cell exhaustion by inducing T-cell inactivation, and high PD-1 expression levels on peripheral T-lymphocytes as well as the ...
Ping-Ning Hsu +2 more
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Abstract Recent studies in animal models of virus infection, indicate that the interaction between the inhibitory receptor programmed death (PD)-1 on lymphocytes and its ligands plays a critical role in T-cell exhaustion by inducing T-cell inactivation, and high PD-1 expression levels on peripheral T-lymphocytes as well as the ...
Ping-Ning Hsu +2 more
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Journal of Pineal Research, 2010
Abstract: This work was undertaken to investigate whether treatment with melatonin prevents oxidative stress and changes in the expression and activity of factor erythroid 2‐related factor 2 (Nrf2)‐mediated antioxidant enzymes in an animal model of fulminant hepatic failure of viral origin.
Irene, Crespo +6 more
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Abstract: This work was undertaken to investigate whether treatment with melatonin prevents oxidative stress and changes in the expression and activity of factor erythroid 2‐related factor 2 (Nrf2)‐mediated antioxidant enzymes in an animal model of fulminant hepatic failure of viral origin.
Irene, Crespo +6 more
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Hepatology, 1989
During long-term studies of the natural history of woodchuck hepatitis virus infection, five cases of histologically confirmed, primary hepatocellular carcinoma were observed in a total of 92 woodchucks which had recovered, by analysis of viral serologic markers (WHsAG−, anti-WHc+, anti-WHs+), from experimental acute woodchuck
B E, Korba +6 more
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During long-term studies of the natural history of woodchuck hepatitis virus infection, five cases of histologically confirmed, primary hepatocellular carcinoma were observed in a total of 92 woodchucks which had recovered, by analysis of viral serologic markers (WHsAG−, anti-WHc+, anti-WHs+), from experimental acute woodchuck
B E, Korba +6 more
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The tree shrews: useful animal models for the viral hepatitis and hepatocellular carcinoma.
Hepato-gastroenterology, 2005Hepatitis B virus (HBV)-induced hepatitis and hepatocellular carcinoma (HCC) are major diseases worldwide. HBV infection and chemical carcinogens such as aflatoxin B1 are known to be two key factors in the development of HCC. Animal models for hepatitis and HCC are very useful in the in vivo studies of mechanism involved in the development and ...
Er-Bin, Yang +3 more
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Gut
Background Enterically transmitted hepatitis viruses, such as hepatitis A virus (HAV) and hepatitis E virus (HEV), remain notable threats to public health. However, stable and reliable animal models of HAV and HEV infection are lacking. Objective
Tianxu Liu +6 more
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Background Enterically transmitted hepatitis viruses, such as hepatitis A virus (HAV) and hepatitis E virus (HEV), remain notable threats to public health. However, stable and reliable animal models of HAV and HEV infection are lacking. Objective
Tianxu Liu +6 more
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