Results 31 to 40 of about 102,448 (310)

Observing micro-evolutionary processes of viral populations at multiple scales [PDF]

, 2013
Advances in sequencing technology coupled with new integrative approaches to data analysis provide a potentially transformative opportunity to use pathogen genome data to advance our understanding of transmission.
Orton, Richard J., Valdazo-Gonzalez, B., King, D.P., Knowles, N.J., Morelli, M.J., Morelli, Marco J., Wright, Caroline F., Haydon, D.T., Juleff, N., Wright, C.F., Paton, D.J., Orton, R.J., Valdazo-Gonzáles, Begoña, Thébaud, Gael, Thebaud, G., Paton, David J., Juleff, Nicholas, King, Donald P., Haydon, Daniel T., Knowles, Nick J.   +19 more
core   +1 more source

Molecular biology and replication of hepatitis E virus

Emerging Microbes and Infections, 2012
Hepatitis E virus (HEV), a single-stranded, positive-sense RNA virus, is responsible for acute hepatitis E epidemics in many developing countries, and the virus is also endemic in some industrialized countries.
Dianjun Cao, Xiang-Jin Meng
doaj   +1 more source

The CYP2D6 animal model: how to induce autoimmune hepatitis in mice

, 2012
Autoimmune hepatitis is a rare but life threatening autoimmune disease of the liver of unknown etiology1,2. In the past many attempts have been made to generate an animal model that reflects the characteristics of the human disease 3-5.
Christen, Urs, Hintermann, Edith, Ehser, Janine   +2 more
core   +1 more source

Autophagic response in the Rabbit Hemorrhagic Disease, an animal model of virally-induced fulminant hepatic failure [PDF]

Veterinary Research, 2014
The Rabbit Hemorrhagic Disease Virus (RHDV) induces a severe disease that fulfils many requirements of an animal model of fulminant hepatic failure. However, a better knowledge of molecular mechanisms contributing to liver damage is required, and it is unknown whether the RHDV induces liver autophagy and how it relates to apoptosis.
Vallejo, Daniela, Crespo, Irene, San-Miguel, Beatriz, Álvarez, Marcelino, Prieto, Jesús, Tuñón, María, González-Gallego, Javier   +6 more
openaire   +3 more sources

Full-Genome Hepatitis B Virus Genotyping: A Juxtaposition of Next-Generation and Clone-Based Sequencing Approaches—Comparing Genotyping Methods of Hepatitis B Virus

Viruses
Background: The enhanced sensitivity of next-generation sequencing (NGS) for assessing hepatitis B virus (HBV) quasispecies heterogeneity over clone-based sequencing (CBS) is well documented.
Li-Ping Hu, Qin-Yan Chen, Mei-Lin Huang, Wen-Jia Zhang, Xiao-Qian Huang, Xian-Feng Yi, Hui-Hua Jia   +6 more
doaj   +1 more source

CD4+ T cells reverse surface antigen persistence in a mouse model of HBV replication

Microbiology Spectrum, 2023
Hepatitis B virus (HBV) is responsible for over 800,000 deaths yearly worldwide. While chronic HBV infection currently has no highly effective cure, immunotherapy has generated interest as a potential therapeutic solution due to the connection between ...
Jacob T. Bailey, Safiehkhatoon Moshkani, Catherine Rexhouse, Jesse L. Cimino, Michael D. Robek   +4 more
doaj   +1 more source

Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection [PDF]

, 2008
Autoimmune liver diseases, such as autoimmune hepatitis (AIH) and primary biliary cirrhosis, often have severe consequences for the patient. Because of a lack of appropriate animal models, not much is known about their potential viral etiology. Infection
Hintereder, Gudrun, Gudrun Hintereder, Michael P. Manns, Christen, Urs, Herrath, Matthias G. von, Holdener, Martin, Monika Bayer, Johnson, Eric F., Urs Christen, Rodrigo, Evelyn, Frank J. Gonzalez, Pfeilschifter, Josef (Prof. Dr.), Eric F. Johnson, Evelyn Rodrigo, Gonzalez, Frank J., Martin Holdener, Edith Hintermann, Hintermann, Edith, Matthias von G. Herrath, Josef Pfeilschifter, Rhode, Antje, Bayer, Monika, Manns, Michael P., Antje Rhode   +23 more
core   +1 more source

Use of Cellular Decapping Activators by Positive-Strand RNA Viruses

Viruses, 2016
Positive-strand RNA viruses have evolved multiple strategies to not only circumvent the hostile decay machinery but to trick it into being a priceless collaborator supporting viral RNA translation and replication.
Jennifer Jungfleisch, Bernat Blasco-Moreno, Juana Díez   +2 more
doaj   +1 more source

Experimental Infection of Rabbits with Rabbit and Genotypes 1 and 4 Hepatitis E Viruses

, 2010
Background: A recent study provided evidence that farmed rabbits in China harbor a novel hepatitis E virus (HEV) genotype. Although the rabbit HEV isolate had 77-79% nucleotide identity to the mammalian HEV genotypes 1 to 4, their genomic organization is
Zheng, L, Ma Yuyuan, Zhang, JG, Liu Yunbo, Zhao, CY, Harrison Tim J., Ma Hongxia, Hongxia Ma, Wang, YC, Wang Youchun, Ma, YY, Yuyuan Ma, Sun, SH, Yunbo Liu, Youchun Wang, Ma, HX, Zhao Chenyan, Harrison, TJ, Zheng Lin, Chenyan Zhao, Jingang Zhang, Zhang Jingang, Tim J Harrison, Lin Zheng, Sun Shuhua, Shuhua Sun, Liu, YB   +26 more
core   +1 more source

The course of hepatitis E virus infection in pigs after contact-infection and intravenous inoculation [PDF]

, 2009
Background Worldwide, hepatitis E virus (HEV) genotype 3 is observed in pigs and transmission to humans is implied. To be able to estimate public health risks from e.g.
Bouwknegt Martijn, Wim H M van der Poel, van der Poel, W.H.M., Frankena Klaas, Rutjes, S.A., Saskia A Rutjes, de Jong Mart CM, van der Poel Wim HM, Poel, W.H.M., van der, Mart C M de Jong, Martijn Bouwknegt, Rutjes Saskia A, Chantal B E M Reusken, de Roda Husman Ana Maria, Ana Maria de Roda Husman, de Roda Husman, A.M., Reusken Chantal BEM, Stockhofe-Zurwieden, N., Frankena, K., de Jong, M.C.M., Roda Husman, A.M., de, Bouwknegt, M., Jong, M.C.M., de, Klaas Frankena, Reusken, C.B.E.M., Stockhofe-Zurwieden Norbert, Norbert Stockhofe-Zurwieden   +26 more
core   +1 more source