Results 21 to 30 of about 104,518 (264)
Liver Monocytes and Kupffer Cells Remain Transcriptionally Distinct during Chronic Viral Infection. [PDF]
PLoS ONE, 2016 Due to the scarcity of immunocompetent animal models for chronic viral hepatitis, little is known about the role of the innate intrahepatic immune system during viral replication in the liver.
Martijn D B van de Garde +7 more
doaj +1 more source
Hepatitis delta virus RNA decline post-inoculation in human NTCP transgenic mice is biphasic
mBio, 2023 Chronic infection with hepatitis B and delta viruses (HDV) is the most serious form of viral hepatitis due to more severe manifestations of an accelerated progression to liver fibrosis, cirrhosis, and hepatocellular carcinoma.
Stephanie Maya +10 more
doaj +1 more source
Viruses, 2017 The human Hepatitis Delta Virus (HDV) is unique among all viral pathogens. Encoding only one protein (Hepatitis Delta Antigen; HDAg) within its viroid-like self-complementary RNA, HDV constitutes the smallest known virus in the animal kingdom.
Florian A. Lempp, Stephan Urban
doaj +1 more source
Autophagic response in the Rabbit Hemorrhagic Disease, an animal model of virally-induced fulminant hepatic failure [PDF]
Veterinary Research, 2014 The Rabbit Hemorrhagic Disease Virus (RHDV) induces a severe disease that fulfils many requirements of an animal model of fulminant hepatic failure. However, a better knowledge of molecular mechanisms contributing to liver damage is required, and it is unknown whether the RHDV induces liver autophagy and how it relates to apoptosis.
Vallejo, Daniela +6 more
openaire +3 more sources
Molecular biology and replication of hepatitis E virus
Emerging Microbes and Infections, 2012 Hepatitis E virus (HEV), a single-stranded, positive-sense RNA virus, is responsible for acute hepatitis E epidemics in many developing countries, and the virus is also endemic in some industrialized countries.
Dianjun Cao, Xiang-Jin Meng
doaj +1 more source
VirusesBackground: The enhanced sensitivity of next-generation sequencing (NGS) for assessing hepatitis B virus (HBV) quasispecies heterogeneity over clone-based sequencing (CBS) is well documented.
Li-Ping Hu +6 more
doaj +1 more source
Tree Shrew as an Emerging Small Animal Model for Human Viral Infection: A Recent Overview
Viruses, 2021 Viral infection is a global public health threat causing millions of deaths. A suitable small animal model is essential for viral pathogenesis and host response studies that could be used in antiviral and vaccine development.
Mohammad Enamul Hoque Kayesh +3 more
doaj +1 more source
Molecules, 2022 Chronic hepatitis induced by hepatitis B virus (HBV) infection is a serious public health problem, leading to hepatic cirrhosis and liver cancer. Although the currently approved medications can reliably decrease the virus load and prevent the development
Lu Yang +5 more
doaj +1 more source
Natural reservoirs for homologs of hepatitis C virus
Emerging Microbes and Infections, 2014 Hepatitis C virus is considered a major public health problem, infecting 2%–3% of the human population. Hepatitis C virus infection causes acute and chronic liver disease, including chronic hepatitis, cirrhosis and hepatocellular carcinoma.
Stephanie Pfaender +3 more
doaj +1 more source
CD4+ T cells reverse surface antigen persistence in a mouse model of HBV replication
Microbiology Spectrum, 2023 Hepatitis B virus (HBV) is responsible for over 800,000 deaths yearly worldwide. While chronic HBV infection currently has no highly effective cure, immunotherapy has generated interest as a potential therapeutic solution due to the connection between ...
Jacob T. Bailey +4 more
doaj +1 more source