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Viral hepatitis E: A disease of humans and animals [PDF]

Veterinarski Glasnik, 2012
The hepatitis E virus is ubiquitous in all parts of the world where pig production exists. The infection occurs in several animal species and its course is mostly asymptomatic. Viral strains isolated from pigs and humans are genetically similar,
Kureljušić Branislav, Ivetić Vojin, Savić Božidar, Kureljušić Jasna, Jezdimirović Nemanja   +4 more
doaj   +3 more sources

PD-1 blockage reverses immune dysfunction and hepatitis B viral persistence in a mouse animal model. [PDF]

PLoS ONE, 2012
Persistent hepatitis B viral (HBV) infection results in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). Recent studies in animal models of viral infection indicate that the interaction between the inhibitory receptor, programmed ...
Horng-Tay Tzeng, Hwei-Fang Tsai, Hsiu-Jung Liao, Yi-Jiun Lin, Lieping Chen, Pei-Jer Chen, Ping-Ning Hsu   +6 more
doaj   +6 more sources

Natural Hepacivirus Infection in Tree Shrews: A Call for Routine Screening in Hepatitis Virus Research [PDF]

Viruses
Hepatitis viruses continue to pose major global health challenges, necessitating the development of reliable and well-characterized experimental models.
Mohammad Enamul Hoque Kayesh, Takahiro Sanada, Michinori Kohara, Kyoko Tsukiyama-Kohara   +3 more
doaj   +2 more sources

Presence and Diversity of Different Enteric Viruses in Wild Norway Rats (Rattus norvegicus)

Viruses, 2021
Rodents are common reservoirs for numerous zoonotic pathogens, but knowledge about diversity of pathogens in rodents is still limited. Here, we investigated the occurrence and genetic diversity of enteric viruses in 51 Norway rats collected in three ...
Sandra Niendorf, Dominik Harms, Katja F. Hellendahl, Elisa Heuser, Sindy Böttcher, Sonja Jacobsen, C.-Thomas Bock, Rainer G. Ulrich   +7 more
doaj   +1 more source

A small animal model of chronic hepatitis E infection using immunocompromised rats

JHEP Reports, 2022
Background & Aims: HEV variants such as swine genotypes within Paslahepevirus species balayani (HEV-A) and rat HEV (Rocahepevirus ratti; HEV-C1) cause chronic hepatitis E in immunocompromised individuals.
Siddharth Sridhar, Shusheng Wu, Jianwen Situ, Estie Hon-Kiu Shun, Zhiyu Li, Anna Jin-Xia Zhang, Kyle Hui, Carol Ho-Yan Fong, Vincent Kwok-Man Poon, Nicholas Foo-Siong Chew, Cyril Chik-Yan Yip, Wan-Mui Chan, Jian-Piao Cai, Kwok-Yung Yuen   +13 more
doaj   +1 more source

Seroprevalence of various viral diseases in Tamil Nadu, India

Journal of Global Infectious Diseases, 2023
Introduction: Virus-borne diseases have recently gained significant public health importance. Viruses infect several hosts, including animal reservoirs, evolve quickly, and recombine emerging and reemerging to pose recurring dangers to humans.
R Gopinath, A L Meenakshi Sundaram, A Dhanasezhian, M Arundadhi, G Sucila Thangam   +4 more
doaj   +1 more source

Modeling Hepatotropic Viral Infections: Cells vs. Animals

Cells, 2021
The lack of an appropriate platform for a better understanding of the molecular basis of hepatitis viruses and the absence of reliable models to identify novel therapeutic agents for a targeted treatment are the two major obstacles for launching ...
Niloofar Khoshdel-Rad, Ensieh Zahmatkesh, Polina Bikmulina, Maria Peshkova, Nastasia Kosheleva, Evgeny A. Bezrukov, Roman B. Sukhanov, Anna Solovieva, Anastasia Shpichka, Peter Timashev, Massoud Vosough   +10 more
doaj   +1 more source

Recent Drug Development in the Woodchuck Model of Chronic Hepatitis B

Viruses, 2022
Infection with hepatitis B virus (HBV) is responsible for the increasing global hepatitis burden, with an estimated 296 million people being carriers and living with the risk of developing chronic liver disease and cancer.
Manasa Suresh, Stephan Menne
doaj   +1 more source

Characterization of innate immune response to hepatitis B virus genotype F acute infection in tree shrew (Tupaia belangeri) model

Frontiers in Virology, 2022
Hepatitis B virus (HBV) infection is a global public health problem. The clinical outcomes of HBV infections are influenced by host as well as viral factors, including viral genotypes and subgenotypes.
Mohammad Enamul Hoque Kayesh, Mohammad Enamul Hoque Kayesh, Mohammad Enamul Hoque Kayesh, Md Abul Hashem, Md Abul Hashem, Takahiro Sanada, Bouchra Kitab, Bouchra Kitab, Md Haroon Or Rashid, Md Haroon Or Rashid, Lipi Akter, Sayeh Ezzikouri, Shuko Murakami, Shintaro Ogawa, Yasuhito Tanaka, Michinori Kohara, Kyoko Tsukiyama-Kohara, Kyoko Tsukiyama-Kohara   +17 more
doaj   +1 more source

Targeting Host Innate and Adaptive Immunity to Achieve the Functional Cure of Chronic Hepatitis B

Vaccines, 2020
Despite the availability of an effective preventive vaccine for hepatitis B virus (HBV) for over 38 years, chronic HBV (CHB) infection remains a global health burden with around 257 million patients. The ideal treatment goal for CHB infection would be to
Sayeh Ezzikouri, Mohammad Enamul Hoque Kayesh, Soumaya Benjelloun, Michinori Kohara, Kyoko Tsukiyama-Kohara   +4 more
doaj   +1 more source