Results 71 to 80 of about 386,204 (264)

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Association of climate variability with hepatitis A and E infections in Dhaka (2016–2023)

Bangabandhu Sheikh Mujib Medical University Journal
Background: Acute viral hepatitis, predominantly caused by hepatitis A virus (HAV) and hepatitis E virus (HEV), remains a major global public health issue, especially in low- and middle-income countries.
S M Rashed Ul Islam, Afsana Anwar Miti, Ayesha Alam Mita, Ridwana Asma, Maruf Ahmed Bhuiyan, Saif Ullah Munshi, Afzalun Nessa   +6 more
doaj   +1 more source

Cysteine Redox State Governs the Condensation Pathway of Hendra Virus W Protein and Differentially Impacts Type I IFN and NF‐κB Signaling

Advanced Science, EarlyView.
The cysteine redox state of the Hendra virus W (WHeV) protein controls assembly into fibrils or amorphous aggregates, with residues 2–29 required for fibrillation. In cells, WHeV forms different types of nuclear condensates. Impaired ability to form redox‐sensitive, non‐filamentous condensates reduces WHeV inhibition of the NF‐κB pathway, while it ...
Frank Gondelaud, Alexandre Lalande, Giulia Pesce, Auriane Bouchet, Carole Meunier, Christophe Bignon, Denis Ptchelkine, Yu Gu, Eva Ogire, Pierre‐Yves Lozach, Denis Gerlier, Cyrille Mathieu, Sonia Longhi   +12 more
wiley   +1 more source

Optimized Ex Vivo Human Liver Slice Culture Maintains Extended Viability and Function for Hepatotoxicity Testing

Advanced Science, EarlyView.
An optimized ex vivo human liver slice culture system preserves tissue architecture, hepatocyte function, and immune‐stromal complexity for at least five days. By refining slice thickness, oxygenation, air‐liquid interface, and extracellular matrix support, the platform enables human‐relevant hepatotoxicity testing and mechanistic studies, offering a ...
Huiche Feng, Cinzia Esposito, Andrej Benjak, Matthias S. Matter, Miriam Cieri, Camilla De Carlo, Philipp Sedlaczek, Fabian Haak, Mattia Marinucci, Gabriel Fridolin Hess, Otto Kollmar, Mairene Coto‐Llerena, Luca Di Tommaso, Visar Vela, Lukas Bubendorf, Luigi M. Terracciano, Charlotte K. Y. Ng, Salvatore Piscuoglio   +17 more
wiley   +1 more source

Infección simultánea por el virus de la hepatitis E y de otras hepatitis virales en Colombia y su caracterización genotípica

Biomédica: revista del Instituto Nacional de Salud, 2016
Introducción. El virus de la hepatitis E se ha convertido en un problema de salud pública, especialmente en los países en desarrollo. Se conocen cuatro genotipos en mamíferos, de los cuales el G3 se ha encontrado en hepatitis autóctonas en países y ...
Dioselina Peláez, Daniel Martínez-Vargas, Martha Escalante-Mora, Mariel Palacios-Vivero, Lady Contreras-Gómez   +4 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

A three-year retrospective study of infectious hepatitis at a teaching hospital in Northern India

Journal of Family Medicine and Primary Care
Background: Infectious hepatitis is primarily attributed to hepatitis A virus (HAV) and hepatitis E virus (HEV) infections, which exhibit distinct geographical distribution patterns and varying prevalence rates worldwide, influenced by factors such as ...
Meenakshi Singh, Gurpreet Banga, Rumana F. Mir, Rosy Bala, Harit Kumar, Narinder Kaur   +5 more
doaj   +1 more source

Hepatitis A virus infection: Epidemiology and genetic diversity

Iatreia, 2015
Hepatitis A virus infection is a global public health problem. The virus has a wide range of distribution and it is the main cause of acute hepatitis transmitted by the enteric route in Latin America.
Báez Triana, Paula Andrea, Navas Navas, María Cristina   +1 more
doaj   +1 more source

Hepatitis E Virus [PDF]

Transfusion Medicine and Hemotherapy, 2015
Pauli, Georg, Aepfelbacher, Martin, Bauerfeind, Ursula, Blümel, Johannes, Burger, Reinhard, Gärtner, Barbara, Gröner, Albrecht, Gürtler, Lutz, Heiden, Margarethe, Hildebrandt, Martin, Jansen, Bernd, Offergeld, Ruth, Schlenkrich, Uwe, Schottstedt, Volkmar, Seitz, Rainer, Strobel, Johanna, Willkommen, Hannelore, Baylis, Sally A.   +17 more
openaire   +3 more sources

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source