Results 11 to 20 of about 94,212 (236)

The Cys-Rich Region of Hepatitis A Virus Cellular Receptor 1 Is Required for Binding of Hepatitis A Virus and Protective Monoclonal Antibody 190/4 [PDF]

Journal of Virology, 1998
ABSTRACT The hepatitis A virus cellular receptor 1 (HAVcr-1) cDNA codes for a class I integral membrane glycoprotein, termed havcr-1, of unknown natural function which serves as an African green monkey kidney (AGMK) cell receptor for HAV. The extracellular domain of havcr-1 has an N-terminal Cys-rich region that displays homology
P, Thompson, J, Lu, G G, Kaplan
openaire   +2 more sources

Immunoglobulin A (IgA) Is a Natural Ligand of Hepatitis A Virus Cellular Receptor 1 (HAVCR1), and the Association of IgA with HAVCR1 Enhances Virus-Receptor Interactions [PDF]

Journal of Virology, 2007
ABSTRACT The hepatitis A virus cellular receptor 1 (HAVCR1/TIM1), a member of the T-cell immunoglobulin mucin (TIM) family, is an important atopy susceptibility gene in humans. The exact natural function of HAVCR1/TIM1 and the inverse association between HAV infection and prevention of atopy are not well understood.
Cecilia, Tami, Erica, Silberstein, Mohanraj, Manangeeswaran, Gordon J, Freeman, Sarah E, Umetsu, Rosemarie H, DeKruyff, Dale T, Umetsu, Gerardo G, Kaplan   +7 more
openaire   +2 more sources

Neutralization of Hepatitis A Virus (HAV) by an Immunoadhesin Containing the Cysteine-Rich Region of HAV Cellular Receptor-1 [PDF]

Journal of Virology, 2001
ABSTRACT Hepatitis A virus (HAV) infects African green monkey kidney (AGMK) cells via the HAV cellular receptor-1 (havcr-1), a mucin-like type 1 integral-membrane glycoprotein of unknown natural function. The ectodomain of havcr-1 contains an N-terminal immunoglobulin-like cysteine-rich region (D1), which binds protective monoclonal antibody (
E, Silberstein, G, Dveksler, G G, Kaplan
openaire   +2 more sources

Accuracy of Urine Kidney Injury Molecule-1 in Predicting Acute Kidney Injury in Children; a Systematic Review and Meta-Analysis

Archives of Academic Emergency Medicine, 2020
Introduction: There is considerable controversy on the accuracy of Kidney Injury Molecule-1 (KIM-1) in prediction of acute kidney injury (AKI) in children. Therefore, the present study intends to provide a systematic review and meta-analysis of the value
Mojtaba Fazel, Arash Sarveazad, Kosar Mohamed Ali, Mahmoud Yousefifard, Mostafa Hosseini   +4 more
doaj   +1 more source

Inhibition of Viral Membrane Fusion by Peptides and Approaches to Peptide Design

Pathogens, 2021
Fusion of lipid-enveloped viruses with the cellular plasma membrane or the endosome membrane is mediated by viral envelope proteins that undergo large conformational changes following binding to receptors.
Nejat Düzgüneş, Narcis Fernandez-Fuentes, Krystyna Konopka   +2 more
doaj   +1 more source

Does mass management of chronic hepatitis C protect the Egyptian population against fulminant coronavirus disease-2019? “Postulating a hypothesis”

The Egyptian Journal of Bronchology, 2022
Coronavirus disease (COVID-19) is caused by the pathogenic virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Egypt has launched a national treatment program to provide a cure for Egyptian patients infected with hepatitis C virus (HCV ...
Essamedin M. Negm
doaj   +1 more source

Augmentation of Hepatitis B Virus-Specific Cellular Immunity with Programmed Death Receptor-1/Programmed Death Receptor-L1 Blockade in Hepatitis B Virus and HIV/Hepatitis B Virus Coinfected Patients Treated with Adefovir [PDF]

AIDS Research and Human Retroviruses, 2013
The immunological parameters leading to viral persistence in chronic hepatitis B (CHB) are not clearly established. We analyzed HBV-specific immunoregulatory mechanisms in HIV-infected and HIV-uninfected HBeAg(+) CHB patients to determine (1) the roles of immunoregulatory pathways, (2) the effect of anti-HBV therapy on immunoregulatory pathways, and (3)
Amy C, Sherman, Nirupama, Trehanpati, Marybeth, Daucher, Richard T, Davey, Henry, Masur, Shiv Kumar, Sarin, Shyam, Kottilil, Anita, Kohli   +7 more
openaire   +2 more sources

Alteration of Hepatitis A Virus (HAV) Particles by a Soluble Form of HAV Cellular Receptor 1 Containing the Immunoglobulin- and Mucin-Like Regions [PDF]

Journal of Virology, 2003
ABSTRACT Hepatitis A virus (HAV) infects African green monkey kidney cells via HAV cellular receptor 1 (havcr-1). The ectodomain of havcr-1 contains an N-terminal cysteine-rich immunoglobulin-like region (D1), followed by a mucin-like region that extends D1 well above the cell surface.
Erica, Silberstein, Li, Xing, Willem, van de Beek, Jinhua, Lu, Holland, Cheng, Gerardo G, Kaplan   +5 more
openaire   +2 more sources

TIM1 (HAVCR1) Is Not Essential for Cellular Entry of Either Quasi-enveloped or Naked Hepatitis A Virions

mBio, 2017
Receptor molecules play key roles in the cellular entry of picornaviruses, and TIM1 (HAVCR1) is widely accepted to be the receptor for hepatitis A virus (HAV), an unusual, hepatotropic human picornavirus.
Anshuman Das, Asuka Hirai-Yuki, Olga González-López, Bethany Rhein, Sven Moller-Tank, Rachel Brouillette, Lucinda Hensley, Ichiro Misumi, William Lovell, John M. Cullen, Jason K. Whitmire, Wendy Maury, Stanley M. Lemon   +12 more
doaj   +1 more source

Structural basis of HCV neutralization by human monoclonal antibodies resistant to viral neutralization escape. [PDF]

PLoS Pathogens, 2013
The high mutation rate of hepatitis C virus allows it to rapidly evade the humoral immune response. However, certain epitopes in the envelope glycoproteins cannot vary without compromising virus viability.
Thomas Krey, Annalisa Meola, Zhen-Yong Keck, Laurence Damier-Piolle, Steven K H Foung, Felix A Rey   +5 more
doaj   +1 more source