Results 31 to 40 of about 94,212 (236)

RACK1 mediates rewiring of intracellular networks induced by hepatitis C virus infection.

PLoS Pathogens, 2019
Hepatitis C virus (HCV) is a positive-strand RNA virus replicating in a membranous replication organelle composed primarily of double-membrane vesicles (DMVs) having morphological resemblance to autophagosomes.
Jae Seung Lee, Keisuke Tabata, Woan-Ing Twu, Md Shafiqur Rahman, Hee Sun Kim, Jin Bae Yu, Min Hyeok Jee, Ralf Bartenschlager, Sung Key Jang   +8 more
doaj   +1 more source

Oxidative Stress Induces Mitochondrial Compromise in CD4 T Cells From Chronically HCV-Infected Individuals

Frontiers in Immunology, 2021
We have previously shown that chronic Hepatitis C virus (HCV) infection can induce DNA damage and immune dysfunctions with excessive oxidative stress in T cells. Furthermore, evidence suggests that HCV contributes to increased susceptibility to metabolic
Madison Schank, Madison Schank, Juan Zhao, Juan Zhao, Ling Wang, Ling Wang, Lam Ngoc Thao Nguyen, Lam Ngoc Thao Nguyen, Dechao Cao, Dechao Cao, Xindi Dang, Xindi Dang, Sushant Khanal, Sushant Khanal, Jinyu Zhang, Jinyu Zhang, Yi Zhang, Yi Zhang, Xiao Y. Wu, Xiao Y. Wu, Shunbin Ning, Shunbin Ning, Mohamed El Gazzar, Mohamed El Gazzar, Jonathan P. Moorman, Jonathan P. Moorman, Jonathan P. Moorman, Zhi Q. Yao, Zhi Q. Yao, Zhi Q. Yao   +29 more
doaj   +1 more source

Nuclear receptor 4 group A member 1 determines hepatitis C virus entry efficiency through the regulation of cellular receptor and apolipoprotein E expression

Journal of General Virology, 2014
Orphan nuclear receptor subfamily 4 group A member 1 (NR4A1) is a transcription factor stimulated by many factors and plays pivotal roles in metabolism, proliferation and apoptosis. In this study, the expression of NR4A1 in Huh7.5.1 cells was significantly upregulated by hepatitis C virus (HCV) infection.
Zhu, Wandi, Pei, Rongjuan, Jin, Rui, Hu, Xue, Zhou, Yuan, Wang, Yun, Wu, Chunchen, Lu, Mengji, Chen, Xinwen   +8 more
openaire   +3 more sources

Coronavirus non-structural protein 1 is a major pathogenicity factor: implications for the rational design of coronavirus vaccines. [PDF]

PLoS Pathogens, 2007
Attenuated viral vaccines can be generated by targeting essential pathogenicity factors. We report here the rational design of an attenuated recombinant coronavirus vaccine based on a deletion in the coding sequence of the non-structural protein 1 (nsp1).
Roland Züst, Luisa Cervantes-Barragán, Thomas Kuri, Gjon Blakqori, Friedemann Weber, Burkhard Ludewig, Volker Thiel   +6 more
doaj   +1 more source

Regulatory phenotype, PD-1 and TLR3 expression in T cells and monocytes from HCV patients undergoing antiviral therapy: a randomized clinical trial.

PLoS ONE, 2014
Background & aimsThe cellular immunity has a profound impact on the status of hepatitis C virus (HCV) infection. However, the response of cellular immunity on the virological response in patients with antiviral treatment remains largely unclear. We aimed
Shan-shan Su, Huan He, Ling-bo Kong, Yu-guo Zhang, Su-xian Zhao, Rong-qi Wang, Huan-wei Zheng, Dian-xing Sun, Yue-min Nan, Jun Yu   +9 more
doaj   +1 more source

A New Signaling Pathway for HCV Inhibition by Estrogen: GPR30 Activation Leads to Cleavage of Occludin by MMP-9. [PDF]

PLoS ONE, 2016
Poor outcome in response to hepatitis C virus, including higher viral load, hepatocellular carcinoma and cirrhosis, is more associated with men and postmenopausal women than with premenopausal women and women receiving hormone replacement therapy ...
Laura Ulitzky, Manuel M Lafer, Mark A KuKuruga, Erica Silberstein, Nicoleta Cehan, Deborah R Taylor   +5 more
doaj   +1 more source

Targeting Oxidative Stress and Inflammation in Pembrolizumab-Induced Renal Injury: A Comparative Evaluation of the Protective Effects of Flunarizine and Carvacrol in Rats

Biomolecules
Background: Pembrolizumab, a programmed cell death protein 1 (PD-1) inhibitor, is widely employed in oncological practice; however, its propensity to induce nephrotoxicity through immune-mediated oxidative and inflammatory mechanisms remains an ...
Engin Hendem, Bulent Yavuzer, Esra Tuba Sezgin, Murat Gunay, Mustafa Ozkaraca, Ali Gungor, Durdu Altuner, Halis Suleyman   +7 more
doaj   +1 more source

In-silico analysis of interacting pathways through KIM-1 protein interaction in diabetic nephropathy

BMC Nephrology, 2022
Background Human Kidney Injury Molecule-1, also known as HAVCR-1 (Hepatitis A virus cellular receptor 1), belongs to the cell-surface protein of immunoglobulin superfamily involved in the phagocytosis by acting as scavenger receptor epithelial cells. The
F. Abid, Z. Rubab, S. Fatima, A. Qureshi, A. Azhar, A. Jafri   +5 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Conformational Flexibility in the CD81-Binding Site of the Hepatitis C Virus Glycoprotein E2

Frontiers in Immunology, 2018
Numerous antibodies have been described that potently neutralize a broad range of hepatitis C virus (HCV) isolates and the majority of these antibodies target the binding site for the cellular receptor CD81 within the major HCV glycoprotein E2.
Luisa J. Ströh, Kumar Nagarathinam, Thomas Krey   +2 more
doaj   +1 more source