Results 81 to 90 of about 94,580 (185)

In vitro toxicity of Lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) on Human Renal and Hepatoma Cells

Toxicology Reports
We evaluate the cytotoxicity, intracellular redox conditions, apoptosis, and methylation of DNMTs/TETs upon exposure to LiTFSI, a novel Per and Polyfluoroalkyl Substances (PFAS) commonly found in lithium-ion batteries, on human renal carcinoma cells ...
Xing Zhang, Mia Sands, Mindy Lin, Jennifer Guelfo, Joseph Irudayaraj   +4 more
doaj   +1 more source

Local TSH/TSHR signaling promotes CD8+ T cell exhaustion and immune evasion in colorectal carcinoma

Cancer Communications
Background Dysfunction of CD8+ T cells in the tumor microenvironment (TME) contributes to tumor immune escape and immunotherapy tolerance. The effects of hormones such as leptin, steroid hormones, and glucocorticoids on T cell function have been reported
Sisi Zeng, Huiling Hu, Zhiyang Li, Qi Hu, Rong Shen, Mingzhou Li, Yunshi Liang, Zuokang Mao, Yandong Zhang, Wanqi Zhan, Qin Zhu, Feifei Wang, Jianbiao Xiao, Bohan Xu, Guanglong Liu, Yanan Wang, Bingsong Li, Shaowan Xu, Zhaowen Zhang, Ceng Zhang, Zhizhang Wang, Li Liang   +21 more
doaj   +1 more source

Harnessing Luteolin's therapeutic potential in human disorders: Medicinal significance, biological, clinical properties and analytical aspects

Pharmacological Research - Modern Chinese Medicine
Introduction: Luteolin (3′,4′,5,7-tetrahydroxyflavone) is a common flavonoid in many fruits, vegetables, and medicinal herbs. Plants rich in luteolin have been used in Chinese traditional medicine for treating various diseases, such as hypertension ...
Abhishek Singh, Seema Yadav, Prateek Pathak, Amita Verma, Jagat Pal Yadav   +4 more
doaj   +1 more source

Dendritic cell function in the setting of chronic hepatitis c infection and changes during antiviral treatment

, 2009
The role of the innate immune system and in particular of dendritic cells, in the establishment of chronic hepatitis C has been studied quite extensively over the last few years but controversy remains as to whether a potential virus-induced defect in
Pachiadakis, I.
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Constraints on the CD8 T cell response in chronic HBV infection [PDF]

, 2009
The inflamed liver in chronic hepatitis B virus infection (CHB) is characterised by a large influx of non-virus specific CD8 T cells, which we hypothesize could provide insights into mechanisms of failure of viral control and liver damage in this setting.
Das, A., Das, A
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Coronavirus non-structural protein 1 is a major pathogenicity factor : implications for the rational design of coronavirus vaccines

, 2007
Zust, Roland Cervantes-Barragan, Luisa Kuri, Thomas Blakqori, Gjon Weber, Friedemann Ludewig, Burkhard Thiel, Volker 5 R21 AI062246/AI/United States NIAID Research Support, N.I.H., Extramural Research Support, Non-U.S.
Thiel Volker, Friedemann Weber, Cervantes-Barragan, L., Kuri, Thomas, Roland Züst, Kuri Thomas, Weber, Friedemann, Weber, F., Volker Thiel, Luisa Cervantes-Barragán, Kuri, T., Zust, R., Ludewig, Burkhard, Blakqori, Gjon, Gjon Blakqori, Ludewig Burkhard, Burkhard Ludewig, Cervantes-Barragán, Luisa, Weber Friedemann, Thiel, Volker, Thomas Kuri, Ludewig, B., Thiel, V., Züst, Roland, Blakqori Gjon, Züst Roland, Cervantes-Barragán Luisa   +26 more
core   +1 more source

Effect of ethanol on innate antiviral pathways and HCV replication in human liver cells

Virology Journal, 2005
Alcohol abuse reduces response rates to IFN therapy in patients with chronic hepatitis C. To model the molecular mechanisms behind this phenotype, we characterized the effects of ethanol on Jak-Stat and MAPK pathways in Huh7 human hepatoma cells, in HCV ...
Fausto Nelson, Lazaro Catherine A, Plumlee Courtney R, Polyak Stephen J   +3 more
doaj   +1 more source

Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal.

, 2013
Protein trafficking between the endoplasmic reticulum (ER) and Golgi apparatus is central to cellular homeostasis. ER export signals are utilized by a subset of proteins to rapidly exit the ER by direct uptake into COPII vesicles for transport to the ...
Estes, M. K., Guix Arnau, Susana, Katayama, K., Crawford, Sue E., Sharp, T. M.   +4 more
core   +1 more source

An interferon-like small chemical compound CDM-3008 suppresses hepatitis B virus through induction of interferon-stimulated genes.

PLoS ONE, 2019
Oral administration of nucleotide analogues and injection of interferon-α (IFNα) are used to achieve immediate suppression in replication of hepatitis B virus (HBV).
Yutaka Furutani, Mariko Toguchi, Yumi Shiozaki-Sato, Xian-Yang Qin, Etsuko Ebisui, Shoko Higuchi, Masayuki Sudoh, Harukazu Suzuki, Nobuaki Takahashi, Koichi Watashi, Takaji Wakita, Hideaki Kakeya, Soichi Kojima   +12 more
doaj   +1 more source

Chicken adenovirus (CELO virus) particles augment receptor-mediated DNA delivery to mammalian cells and yield exceptional levels of stable transformants. [PDF]

, 1993
Delivery of genes via receptor-mediated endocytosis is severely limited by the poor exit of endocytosed DNA from the endosome. A large enhancement in delivery efficiency has been obtained by including human adenovirus particles in the delivery system ...
Malt Cotlen, Kurt Zatloukal, Max, Wagner, E., L. Birnstiel, Wagner, Ernst, Birnstiel, Max L., Ernst Wagner, Cotten, Matt, Zatloukal, Kurt, Cotten, M., Zatloukal, K., Birnstiel, M.L.   +12 more
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