Results 91 to 100 of about 478,399 (303)

Helicobacter pylori infection may increase the risk of progression of chronic hepatitis B disease among the Chinese population: a meta-analysis

open access: yesInternational Journal of Infectious Diseases, 2016
Objectives: Helicobacter pylori is a bacterium that infects over 50% of the human population worldwide. An increasing number of studies have demonstrated that H. pylori may cause liver diseases, and the underlying relationship between H. pylori infection
Juan Wang   +8 more
doaj   +1 more source

Serum hyaluronate as a non-invasive marker of hepatic fibrosis and inflammation in HBeAg-negative chronic hepatitis B [PDF]

open access: yes, 2005
Background: HBV infection is a serious global heath problem. It is crucial to monitor this disease more closely with a non-invasive marker in clinical trials.
Derakhshan, M.H.   +9 more
core   +4 more sources

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

open access: yesAdvanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang   +14 more
wiley   +1 more source

Adefovir Dipivoxil for the Treatment of Hepatitis B e Antigen–Positive Chronic Hepatitis B [PDF]

open access: yes, 2003
BACKGROUND In preclinical and phase 2 studies, adefovir dipivoxil demonstrated potent activity against hepatitis B virus (HBV), including lamivudine-resistant strains.
Brosgart, Carol L., , M.D.   +11 more
core   +2 more sources

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

open access: yesAdvanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz   +10 more
wiley   +1 more source

Evaluation of Interleukin-10 Gene Promoter Polymorphism (-819 C/T) in Patients with Chronic Hepatitis B Virus Infection

open access: yesمجله دانشکده پزشکی اصفهان, 2018
Background: Hepatitis B infection is a major epidemiological problem. The clinical outcome of hepatitis B virus infection varies between individuals from spontaneous viral clearance to chronic hepatitis.
Farzaneh Sadat Mirfakhar   +7 more
doaj   +1 more source

A Deep Representation Learning Method for Quantitative Immune Defense Function Evaluation and Its Clinical Applications

open access: yesAdvanced Science, EarlyView.
ImmuDef, a novel algorithm to quantitatively evaluate the anti‐infection immune defense function of an individual based on RNA‐seq data via a variational autoencoder (VAE) model. It is validated on 3200+ samples across four immune states with high accuracy. It can serve as a metric for disease severity and prognosis across pathogenic cohorts.
Zhen‐Lin Tan   +7 more
wiley   +1 more source

World's longest surviving liver-pancreas recipient [PDF]

open access: yes, 2007
In July 1988, the liver and pancreas of a cadaveric donor were transplanted separately into a man with type 1 diabetes with end-stage chronic hepatitis B virus.
Alessiani   +20 more
core   +1 more source

Study of liver in HBV-related hepatocellular carcinoma: Stereology shows quantitative differences in liver structure

open access: yesEuropean Journal of Histochemistry, 2018
Hepatocellular carcinoma is one of the main consequences of liver chronic disease. Hepatocellular carcinoma-related changes may be seen in patients with chronic hepatitis B.
Bita Moudi   +2 more
doaj   +1 more source

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