Results 111 to 120 of about 14,072,748 (310)

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Erratum for “Associations of expressions of HBcAg and HBsAg with the histologic activity of liver disease and viral replication”

Gut and Liver, 2009
Acute pancreatitis may complicate viral hepatitis B, as well as the other causes of viral hepatitis. There have been reports of acute pancreatitis complicating acute exacerbations of chronic hepatitis B virus infection, most of which were related to ...
doaj   +1 more source

Safety and Efficacy of Hepatitis B Vaccination in Cirrhosis of Liver

Advances in Virology, 2013
Introduction. Patients with chronic liver disease (CLD) are more likely to have severe morbidity and fatality rate due to superimposed acute or chronic hepatitis B (HBV) infection. The literature has shown that hepatitis B vaccines are safe and effective
D. Ajith Roni, Rama Mohan Pathapati, A. Sathish Kumar, Lalit Nihal, K. Sridhar, Sujith Tumkur Rajashekar   +5 more
doaj   +1 more source

Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection. [PDF]

, 2012
The S-type lectin galectin-9 binds to the negative regulatory molecule Tim-3 on T cells and induces their apoptotic deletion or functional inactivation.
Cheng, Y, Richard Gilson, Singh, HD, Nebbia Gaia, Dusheiko, G., William Rosenberg, Peppa, D, Cheng, Y., Geoffrey Dusheiko, Cheng Yang, Joanne ChinAleong, ChinAleong, J, Patrick Kennedy, Dusheiko Geoffrey, Maini Mala K., Singh Harsimran D., Pooja Khanna, Maini, MK, Nebbia, G., Khanna, P, Gaia Nebbia (125377), Rosenberg, W, Rosenberg William, Rosenberg, W., Schurich, Anna; id_orcid, Gilson, R, ChinAleong Joanne, Mala K. Maini (125417), Patrick Kennedy (125414), Mala K Maini, Harsimran D Singh, Gilson Richard, ChinAleong, J., Gaia Nebbia, Harsimran D. Singh (125388), Nebbia, G, Khanna Pooja, Kennedy, P., Richard Gilson (125405), Schurich, A, Anna Schurich, Joanne ChinAleong (125409), Geoffrey Dusheiko (125400), Kennedy, P, Singh, H.D., Pooja Khanna (125385), William Rosenberg (14858), Khanna, P., Peppa Dimitra, Gilson, R., Kennedy Patrick, Yang Cheng (125394), Dusheiko, G, Dimitra Peppa, Dimitra Peppa (125379), Yang Cheng, Anna Schurich (125382), Maini, M.K., Peppa, D., Schurich Anna   +59 more
core   +1 more source

Helicobacter pylori‐Induced Persistent IGF2BP1 Activation Promotes Ferroptosis Resistance in Gastric Tumorigenesis

Advanced Science, EarlyView.
Helicobacter pylori infection induces sustained upregulation of the RNA‐binding protein IGF2BP1 in gastric epithelial cells, establishing a persistent epitranscriptomic program. IGF2BP1 stabilizes SLC7A11 mRNA in an m6A‐dependent manner to suppress ferroptosis and promote epithelial survival under oxidative stress. Pharmacological inhibition of IGF2BP1
Jing Ning, Xin Guan, Xinyu Hao, Jing Zhang, Deyao Li, Ying Xiong, Wenlin Zhang, Xiurui Han, Yanfei Lang, Meiling Zhou, Mengjie Yang, Zhi Huang, Tinghui Qu, Ming Zu, Qiao Meng, Weiwei Fu, Fengmin Lu, Jing Zhang, Xiangmei Chen, Tong Liu, Shigang Ding   +20 more
wiley   +1 more source

Hepatitis

مجله دانشکده پزشکی اصفهان, 2011
The five known causes of acute hepatitis are the hepatitis A (HAV), B (HBV), C (HCV), D (HDV), and E (HEV) viruses. Hepatitis A and E are forms of infectious hepatitis which spread largely by the fecal-oral route, occur in outbreaks a well as ...
Hamid kalantari
doaj  

Hepatitis B virus infection as a risk factor for chronic kidney disease: a systematic review and meta-analysis

BMC Infectious Diseases
Background Currently, several studies have observed that chronic hepatitis B virus infection is associated with the pathogenesis of kidney disease. However, the extent of the correlation between hepatitis B virus infection and the chronic kidney disease ...
Danjing Chen, Rong Yu, Shuo Yin, Wenxin Qiu, Jiangwang Fang, Xian-e Peng   +5 more
doaj   +1 more source

Socio-Epidemiological and Clinical-Laboratory Characteristics of Patients with HIV and Chronic Hepatitis B+D

Журнал инфектологии
The hepatitis B virus (HBV) and the disease it causes have been actively studied for over 50 years. Recent estimates provided by the World Health Organization indicate that approximately 1 in 22 (4.5%) individuals with chronic hepatitis B have antibodies
E. B. Yastrebova, A. G. Trishina, S. Yu. Romanova, T. N. Vinogradova   +3 more
doaj   +1 more source

Natural History of Chronic Hepatitis B Revealed

, 2012
Chronic hepatitis B is a worldwide public health challenge. Knowledge of natural history of chronic hepatitis B is important for the management of the disease. A community- based prospective cohort study was carried out to evaluate the risk predictors of
CHEN, CHIEN-JEN;YANG, HWAI-I, 陳建仁;楊懷壹   +1 more
core