Results 21 to 30 of about 14,427,656 (303)

Escaping high viral load exhaustion: CD8 cells with altered tetramer binding in chronic hepatitis B virus infection [PDF]

, 2002
Deletion, anergy, and a spectrum of functional impairments can affect virus-specific CD8 cells in chronic viral infections. Here we characterize a low frequency population of CD8 cells present in chronic hepatitis B virus (HBV) infection which survive in
Ogg, GS, Antonio Bertoletti, Brown, D., Dusheiko, G., Brown, D, Geoff Dusheiko, Williams, R., George J.M. Webster, Webster, GJ, Seneviratne, SL, Webster, G.J.M., Reignat, S, David Brown, Mala K. Maini, Stephanie Reignat, King, A., Dusheiko, G, Maini, MK, Bertoletti, A, Suranjith L. Seneviratne, Roger Williams, King, A, Bertoletti, A., Reignat, S., Williams, R, Maini, M.K., Graham S. Ogg, Abigail King, Ogg, G.S., Seneviratne, S.L.   +29 more
core   +1 more source

Serosurveillance of vaccine preventable diseases and hepatitis C in healthcare workers from Lao PDR. [PDF]

PLoS ONE, 2015
BACKGROUND AND AIMS:Healthcare workers (HCW) have an increased risk of exposure to infectious diseases and are a potential source of infections for their patients.
Antony P Black, Keooudomphone Vilivong, Phonethipsavanh Nouanthong, Chanthasone Souvannaso, Judith M Hübschen, Claude P Muller   +5 more
doaj   +1 more source

Linearized hepatitis B surface antigen and hepatitis B core-related antigen in the natural history of chronic hepatitis B [PDF]

Clinical Microbiology and Infection, 2014
Changes in two novel HBV serological markers, linearized hepatitis B surface antigen (HQ-HBsAg) and hepatitis B core-related antigen (HBcrAg), in the natural history of chronic hepatitis B (CHB) have not been well characterized. Serum HQ-HBsAg and HBcrAg levels of 404 Asian treatment-naïve CHB patients were analysed in a cross-sectional manner ...
Wong, DKH, Seto, WKW, Fung, JYY, Huang, FY, Liu, KS, Lai, CL, Yuen, RMF   +6 more
openaire   +4 more sources

Viral adaptation to host immune responses occurs in chronic hepatitis B virus (HBV) infection, and adaptation is greatest in HBV e antigen-negative disease [PDF]

, 2012
Hepatitis B virus (HBV)-specific T-cell responses are important in the natural history of HBV infection. The number of known HBV-specific T-cell epitopes is limited, and it is not clear whether viral evolution occurs in chronic HBV infection. We aimed to
Chopra, A., Gordon, A, Scott Bowden, Pfafferott, K, Desmond, P.V., Ian R. James, Revill, P.A., Chopra, A, Mallal, SA, Silvana Gaudieri, Anna Ayres, Lewin, S.R., Thompson, AJ, Desmond, C.P., Jennifer Audsley, James, IR, Locarnini, SA, Stephen A. Locarnini, Sharon R. Lewin, James, I.R., Locarnini, S.A., Chivers, S., Christopher P. Desmond, Desmond, PV, Thompson, A.J., Stuart K. Roberts, Audsley, J, Revill, PA, Lau, GK, Gaudieri, S, Gaudieri, S., Audsley, J., Day, C, Caroline Day, Ayres, A, Day, C., Paul V. Desmond, Pfafferott, K., Gordon, A., Roberts, SK, Peter A. Revill, Alexander J. Thompson, Ayres, A., Desmond, CP, Sarah Chivers, Katja Pfafferott, Bowden, S., George K. Lau, Simon A. Mallal, Lewinb, SR, Lau, G.K., Roberts, S. K., Abha Chopra, Bowden, S, Mallal, S.A., Adam Gordon, Chivers, S   +56 more
core   +1 more source

Frequency of Occult Hepatitis B in Pregnant Women Attending Antenatal Care Unit of a Tertiary Care Hospital

Proceedings, 2021
Introduction: Occult infections (OBIs) caused by hepatitis B virus (HBV) are detected by the presence of HBV DNA without surface antigens. The prevalence of HBsAg in general population of Pakistan is around 3%, but there is no data regarding the ...
Sameen Bint Ali, Mateen Izhar, Chetan Lal, Asma Yaqoob, Hadiqa tul Hafsa, Asma Akram   +5 more
doaj   +1 more source

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

HBsAg expression of liver correlates with histological activities and viral replication in chronic hepatitis B

Annals of Hepatology, 2014
Introduction. The intrahepatic hepatitis B surface antigens (HBsAg) expression is related to disease progression of chronic hepatitis B. We examined the features of intrahepatic HBsAg expression.Material and methods.
Pin-Nan Cheng, Yen-Cheng Chiu, Hung-Wen Tsai, Ru-Hsueh Wang, Hung-Chih Chiu, I-Chin Wu, Ting-Tsung Chang   +6 more
doaj   +1 more source

Inhibition of the HCV core protein on the immune response to HBV surface antigen and on HBV gene expression and replication in vivo. [PDF]

PLoS ONE, 2012
The hepatitis C virus (HCV) core protein is a multifunctional protein that can interfere with the induction of an immune response. It has been reported that the HCV core protein inhibits HBV replication in vitro.
Wenbo Zhu, Chunchen Wu, Wanyu Deng, Rongjun Pei, Yun Wang, Liang Cao, Bo Qin, Mengji Lu, Xinwen Chen   +8 more
doaj   +1 more source

Cellular immune responses in patients with hepatitis B surface antigen seroclearance induced by antiviral therapy

Virology Journal, 2011
Background The mechanisms by which chronic hepatitis B is completely resolved through antiviral therapy are unknown, and the contribution of acquired T cell immunity to hepatitis B surface antigen (HBsAg) seroclearance has not been investigated ...
Zhu Xiaolin, Sun Jian, Wang Zhanhui, Chen Jinjun, Zhang Junchang, Zhou Bin, Hu Xiaoxiong, Ma Shiwu, Liang Minfeng, Abbott William, Hou Jinlin   +10 more
doaj   +1 more source

Identification of novel neutralizing determinants for protection against HCV

Hepatology, EarlyView., 2022
Identification of novel neutralizing determinants for protection against hepatitis C virus. Abstract Background and Aims HCV evasion of neutralizing antibodies (nAb) results in viral persistence and poses challenges to the development of an urgently needed vaccine.
Garazi P. Alzua, Anne F. Pihl, Anna Offersgaard, Rodrigo Velázquez‐Moctezuma, Carlos R. Duarte Hernandez, Elias H. Augestad, Ulrik Fahnøe, Christian K. Mathiesen, Henrik Krarup, Mansun Law, Jannick Prentoe, Jens Bukh, Judith M. Gottwein   +12 more
wiley   +1 more source