NSun2‐Mediated tsRNAs Alleviate Liver Fibrosis via FAK Dephosphorylation
NSun2 deficiency inhibited sinusoidal capillarization, alleviating liver fibrosis. Reduced NSun2 expression led to alterations in the functional tsRNAs tRF‐1‐S25 and tRF‐5‐V31, which regulate sinusoidal capillarization by targeting key proteins, including DUSP1 and FAK – crucial clinical targets – offering a novel RNA‐based therapeutic approach for ...
Pengcheng Li+14 more
wiley +1 more source
Alloimmunization in a Rhesus (Rh) D-Negative Pregnant Woman With an Uncommon Rh Phenotype: A Case Report. [PDF]
Davad D, Majithiya HD, Nagda J.
europepmc +1 more source
CRISPR‐Cas systems offer transformative genome editing capabilities for precise manipulation of cellular genes. This enables two main therapeutic avenues: ex vivo modification of patient cells for re‐transplantation or direct in vivo gene targeting via advanced delivery methods.
Bahareh Farasati Far+4 more
wiley +1 more source
Advances in vaccine adjuvant development and future perspectives. [PDF]
Sinani G, Şenel S.
europepmc +1 more source
Fermentation of recombinant yeast producing hepatitis B surface antigen [PDF]
C. E. Carty+3 more
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Vaccination in Multiple Myeloma: Challenges and Strategies
ABSTRACT Background Multiple myeloma (MM) is a hematological malignancy characterized by profound immunosuppression resulting from both disease‐related mechanisms and treatment‐induced immune dysfunction. This compromised immune status markedly increases susceptibility to infections, a leading cause of morbidity and mortality in MM patients.
Enrica Antonia Martino+10 more
wiley +1 more source
Nano/Micro-Enabled Modification and Innovation of Conventional Adjuvants for Next-Generation Vaccines. [PDF]
Liu X+5 more
europepmc +1 more source
Age‐Specific Prevalence of Hepatitis B e Antigen (HBeAg) and Antibody to HBeAg (Anti‐HBe) among Asymptomatic Hepatitis B Surface Antigen (HBsAg) Carriers in Okinawa and Kyushu, Japan [PDF]
Seizaburo Kashiwagi+7 more
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Summary Two foals were being treated with a combination of oral doxycycline and rifampin for presumed Rhodococcus equi infections. After 3–4 weeks of antimicrobial administration, both foals presented with icterus and nonspecific clinical signs, including lethargy and inappetence.
A. Murdock+7 more
wiley +1 more source
Hepatitis B virus exposure among adolescents living with HIV: a cross-sectional study of samples referred to the national viral load and early infant diagnosis reference laboratory in Uganda. [PDF]
Turyamubona A+9 more
europepmc +1 more source