HCV re‐infection is common after spontaneous clearance of the initial infection. In the rare group of super‐clearers who clear repeatedly, HCV‐specific CD8+ T memory stem cells (TSCM) retain stemness, proliferation, and multipotency, sustaining immune protection. In contrast, clearer chronics lose these properties.
Yanran Zhao +10 more
wiley +1 more source
Review of: "M-cell targeting acid-resistant oral vaccine delivery for immunization against Hepatitis B infection using cationic solid lipid nanoparticles" [PDF]
Kazem Ghaffari
openalex +1 more source
The impact of two-year community-wide pharmacy interventions on the public's knowledge, attitudes, beliefs and behaviors about pharmacists as immunizers. [PDF]
Halperin DM +8 more
europepmc +1 more source
IL‐10‐ and IL‐13‐Biased T Cell Responses to SARS‐CoV‐2 Vaccination in Diabetes
How the immune system of people with diabetes responds to vaccination against respiratory viruses is not well understood. Using activation‐induced markers to identify, quantify, and functionally characterize Spike‐specific CD4+ and CD8+ T cells after SARS‐CoV‐2 vaccination, we show defects in T cell memory maintenance and an IL‐10 and IL‐13‐dominated T
Emma M. Jones +13 more
wiley +1 more source
Immunogenicity and Safety of Sabin Strain Inactivated Poliovirus Vaccine Booster Dose Administered Separately or Concomitantly with Inactivated Hepatitis A Vaccine or Measles-Mumps-Rubella Combined Attenuated Live Vaccine: An Open-Labelled, Randomized, Controlled, Phase 4 Clinical Trial. [PDF]
Hu J +10 more
europepmc +1 more source
Dynamical Modelling and Optimal Control of Conjunctivitis Epidemic
Conjunctivitis disease was modelled using a deterministic modelling approach, with the dynamics presented by the compartments in the flowchart. The results showed that intervention D is the best cost‐effectiveness policy. ABSTRACT In this study, we develop a mathematical model for conjunctivitis transmission dynamics.
Sacrifice Nana‐Kyere +5 more
wiley +1 more source
Immunisation decision-making and barriers to vaccine uptake among children under-5 in limited-resource settings. [PDF]
Adeyanju GC.
europepmc +1 more source
Abstract In Japan, the percentage of approved drugs with pediatric indications increased to 30% in 2010‐2015, but no further increase was observed through 2020. The Ministry of Health, Labor, and Welfare in Japan presented draft future directions to promote pediatric drug development, where the modeling and simulation (M&S) approach was introduced as a
Akinori Nakashima +5 more
wiley +1 more source
Do the therapeutic vaccines hold hope for the treatment of hepatitis B? [PDF]
Yan Q, Fu X, Wang Y, Wang G.
europepmc +1 more source

