Results 81 to 90 of about 459,041 (305)

Adverse Pregnancy Outcomes and Prognostic Factors in Hepatitis B Virus Patients with Intrahepatic Cholestasis During Pregnancy

Clinical and Experimental Obstetrics & Gynecology
Background: We conducted this study to investigate adverse pregnancy outcomes of hepatitis B virus infection coexistng with intrahepatic cholestasis in pregnant women, along with identifying associated risk factors.
Chong Zhang, Hong Wei, Zhiqiang Zhao, Yunxia Zhu   +3 more
doaj   +1 more source

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

Phase Ib study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis

Hepatology, EarlyView., 2022
Phase 1b study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis. Abstract Background and Aims We evaluated the efficacy and safety of the antiangiogenic tyrosine kinase inhibitor anlotinib plus TQB2450, a programmed death‐ligand 1 inhibitor in pretreated advanced biliary tract cancers (BTCs ...
Jun Zhou, Yongkun Sun, Wen Zhang, Jiajia Yuan, Zhi Peng, Wei Wang, Jifang Gong, Lin Yang, Yanshuo Cao, Hong Zhao, Chao Chen, Weifeng Wang, Lin Shen, Aiping Zhou   +13 more
wiley   +1 more source

Comprehensive Identification of Bridge Genes to Explain the Progression from Chronic Hepatitis B Virus Infection to Hepatocellular Carcinoma

Journal of Inflammation Research, 2021
Wenwei Nong,1,* Liping Ma,2,* Biyang Lan,1 Ning Liu,1 Hongzhi Yang,1 Xiaoxia Lao,2 Qiaomei Deng,2 Zhihu Huang2 1Department of General Surgery, Affiliated Minzu Hospital of Guangxi Medical University, Nanning, People’s Republic of China; 2Department
Nong W, Ma L, Lan B, Liu N, Yang H, Lao X, Deng Q, Huang Z   +7 more
doaj  

Primary Seronegative but Molecularly Evident Hepadnaviral Infection Engages Liver and Induces Hepatocarcinoma in the Woodchuck Model of Hepatitis B [PDF]

, 2014
Hepadnavirus at very low doses establishes in woodchucks asymptomatic, serologically undetectable but molecularly evident persistent infection. This primary occult infection (POI) preferentially engages the immune system and initiates virus-specific T ...
Chauhan, Ranjit
core   +1 more source

Droplet Digital CRISPR for Nucleic Acid Detection

Advanced Science, EarlyView.
This review outlines recent advances in droplet digital CRISPR technology for nucleic acid detection, combining CRISPR specificity with droplet digital‐based absolute quantification. It summarizes core principles, amplification‐assisted and amplification‐free strategies, and representative DNA and RNA biomarker applications.
Yang Zhang, Roy S. K. Walker, Anwar Sunna, Tracie J. Barber, Ming Li   +4 more
wiley   +1 more source

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

Disparities and risks of sexually transmissible infections among men who have sex with men in China: a meta-analysis and data synthesis. [PDF]

, 2014
BACKGROUND: Sexually transmitted infections (STIs), including Hepatitis B and C virus, are emerging public health risks in China, especially among men who have sex with men (MSM).
A Liberati, A Thornton, AL Cunningham, AN Poon, B Zhang, B Zhang, BC Zhang, BC Zhang, BC Zhang, BC Zhang, C Beyrer, C Diamond, C Wang, C Wang, C Yang, C Zhou, CF Houlihan, CG Lu, CG Lu, CH Wang, CJ Hoffmann, CM Vajdic, CS Graham, CT Gong, CX Zhou, CX Zhou, D Altman, D Bradshaw, D Cox, D Joshi, D Zhang, DA Machalek, DD Zhang, DT Fleming, DY Sun, EA Operskalski, EE Freeman, EP Chow, EP Chow, EP Chow, EP Chow, Eric J. Nehl, Eric P. F. Chow, F Jin, F Jin, F Song, F Yuan, FH Xue, Frank Y. Wong, FY Mao, G Chen, GF Cai, GF Zhang, GH Lan, GL Ma, GR Seage 3rd, H Guo, H He, H Klein, H Lin, H Shang, H Ward, H Zhang, H Zou, HL Wang, HW Xiao, HY Lu, J Buffington, J Jiang, J Wu, J Wu, JA Rottingen, JA Sterne, JA Sterne, JD Tucker, JF Feng, JF Hu, JH MacLachlan, JL Fleiss, JL Harris, JL Yao, JM Palefsky, Joseph D. Tucker, JP Higgins, JP Higgins, JR Lama, JT Lau, JT Lau, Julian W. Tang, JX Wang, KH Choi, KH Mayer, KH Mayer, KT Bernstein, L Gao, L Liang, L Lu, L Mei, L Wang, L Zhang, L Zhang, L Zhang, L Zhang, Lei Zhang, LF Johnson, LF Xi, LG Feng, LP Deng, M Milošević, M Singer, M Wang, M Zhang, M Zheng, MA Stanley, MC Singer, MG Peters, MJ Donlin, ML Sun, MS Cohen, MZ Liao, N He, NM Boukli, P Chen, P Van de Ven, PJ Saxton, PL Liu, PL Reiter, PV Chin-Hong, Q He, Q He, Q He, Q Hu, QL Yu, R DerSimonian, R Quinn, R Zhang, RS Remis, S Dai, S Kippax, S Liu, S Sanderson, SH Chen, SH Chen, SH Chen, SH Mooij, SR Galvin, SZ Qi, T Hesketh, T Hesketh, T Wang, TB Huedo-Medina, TJ van de Laar, TJ van de Laar, V Soriano, W Wang, WD Cai, WD Shi, WH Wang, WL Parish, X Cai, X Han, X Liang, X Ma, X Meng, X Wang, X Zhang, X Zhu, X Zhuang, X Zhuang, XB Ding, XD Shi, XH Zhao, XL Miao, XM Chen, XP Huan, XS Chen, XS Chen, Xun Zhuang, XX Chen, Y Bai, Y Feng, Y Gu, Y Hong, Y Hu, Y Lan, Y Li, Y Liu, Y Ruan, Y Ruan, Y Wang, Y Wang, Y Zhang, Yanjie Wang, YP Yin, YQ Weng, YY Liu, Z Luo, ZF Miao, ZH Zhou, ZJ Wang, ZK Zhang, ZX Sun   +201 more
core   +4 more sources

Genome‐Wide CRISPR Screen Reveals PIK3CA Inhibition Enhances Lipid Nanoparticle‐Mediated siRNA Delivery

Advanced Science, EarlyView.
A genome‐wide CRISPR screen and identifies PIK3CA as a key regulator of lipid nanoparticle (LNP) uptake is performed. Modulating PIK3CA with small‐molecule inhibitor BAY1082439 enhanced LNP uptake, siRNA delivery, and gene silencing in a variety of epithelial cells, and improved therapeutic outcomes in vivo.
Wenhan Wang, Kangfu Chen, Zongjie Wang
wiley   +1 more source

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara   +29 more
wiley   +1 more source