Results 171 to 180 of about 159,244 (259)

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

open access: yesiNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen   +6 more
wiley   +1 more source

Engineered extracellular vesicles for precision renal therapy: Bioengineering strategies and clinical translation

open access: yesInterdisciplinary Medicine, EarlyView.
Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi   +6 more
wiley   +1 more source

Freeze-drying of live virus vaccines : a review [PDF]

open access: yes, 2015
Daoussi, R   +4 more
core   +2 more sources

Study of Risk Factors and Image Findings of Isolated Abdominal Incidentally Detected Aortic Dissection

open access: yesJournal of Clinical Ultrasound, Volume 53, Issue 3, Page 429-435, March/April 2025.
We detect the risk factors and image characteristics of incidentally detected IAAD. Independent risk factors of IAAD included fatty liver and smoking. In the ultrasound findings of IAAD, an intimal flap was frequently observed. In the CT scan, displacement of intimal calcifications was frequently observed. For suspected IAAD, the abdominal aorta should
Hiromasa Tsubouchi   +15 more
wiley   +1 more source

Reframing Post‐Hepatectomy Liver Failure as a Determinant of Post‐Recurrence Survival in HCC

open access: yesJournal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Post‐hepatectomy liver failure (PHLF) is traditionally considered a transient perioperative complication with limited long‐term consequences, yet its long‐term oncologic implications in hepatocellular carcinoma (HCC) remain unclear. Methods Patients undergoing primary hepatectomy for HCC between 2007 and 2018 were analyzed.
Hiroshi Horie   +7 more
wiley   +1 more source

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