Results 11 to 20 of about 95,991 (217)

DIFFERENTIAL CYTOKINE PROFILES IN PATIENTS WITH VIRAL AND NON-VIRAL RELATED LIVER CIRRHOSIS [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 2021
Cytokines are pleiotropic peptides that are produced by nearly every nucleated cell in the human body. The liver is one of the most affected tissues. Hepatic inflammation, apoptosis and necrosis of liver cells, cholestasis, fibrosis, and cirrhosis are ...
Sara A El-Mokhtar, Omnia El-Badawy, Helal F Hetta, Mohamed O Abdel-Malek, Noha A Afifi   +4 more
doaj   +1 more source

Natural reservoirs for homologs of hepatitis C virus

Emerging Microbes and Infections, 2014
Hepatitis C virus is considered a major public health problem, infecting 2%–3% of the human population. Hepatitis C virus infection causes acute and chronic liver disease, including chronic hepatitis, cirrhosis and hepatocellular carcinoma.
Stephanie Pfaender, Richard JP Brown, Thomas Pietschmann, Eike Steinmann   +3 more
doaj   +1 more source

Identification of Rodent Homologs of Hepatitis C Virus and Pegiviruses

mBio, 2013
Hepatitis C virus (HCV) and human pegivirus (HPgV or GB virus C) are globally distributed and infect 2 to 5% of the human population. The lack of tractable-animal models for these viruses, in particular for HCV, has hampered the study of infection ...
Amit Kapoor, Peter Simmonds, Troels K. H. Scheel, Brian Hjelle, John M. Cullen, Peter D. Burbelo, Lokendra V. Chauhan, Raja Duraisamy, Maria Sanchez Leon, Komal Jain, Kurt Jason Vandegrift, Charles H. Calisher, Charles M. Rice, W. Ian Lipkin   +13 more
doaj   +1 more source

Characterization of innate immune response to hepatitis B virus genotype F acute infection in tree shrew (Tupaia belangeri) model

Frontiers in Virology, 2022
Hepatitis B virus (HBV) infection is a global public health problem. The clinical outcomes of HBV infections are influenced by host as well as viral factors, including viral genotypes and subgenotypes.
Mohammad Enamul Hoque Kayesh, Mohammad Enamul Hoque Kayesh, Mohammad Enamul Hoque Kayesh, Md Abul Hashem, Md Abul Hashem, Takahiro Sanada, Bouchra Kitab, Bouchra Kitab, Md Haroon Or Rashid, Md Haroon Or Rashid, Lipi Akter, Sayeh Ezzikouri, Shuko Murakami, Shintaro Ogawa, Yasuhito Tanaka, Michinori Kohara, Kyoko Tsukiyama-Kohara, Kyoko Tsukiyama-Kohara   +17 more
doaj   +1 more source

HCV infection in northeastern Brazil: unexpected high prevalence of genotype 3a and absence of African genotypes [PDF]

Arquivos de Gastroenterologia, 2000
The genomic diversity of HCV embraces 6 genotypes and at least 52 subtypes with clinical and epidemiological correlations. There is a paucity of studies assessing HCV genotypes and biomolecular epidemiology in Brazil. We studied genotype distribution and
Raymundo PARANÁ, Ludmila VITVITSKI, Françoise BERBY, Marcelo PORTUGAL, Helma P. COTRIM, Andrea CAVALCANTE, Luiz LYRA, Christian TREPO   +7 more
doaj  

Antiviral Toll-like Receptor Signaling in Non-Parenchymal Liver Cells Is Restricted to TLR3

Viruses, 2022
The role of non-parenchymal liver cells as part of the hepatic, innate immune system in the defense against hepatotropic viruses is not well understood. Here, primary human Kupffer cells, liver sinusoidal endothelial cells and hepatic stellate cells were
Melanie Werner, Stefan Schefczyk, Martin Trippler, Juergen W. Treckmann, Hideo A. Baba, Guido Gerken, Joerg F. Schlaak, Ruth Broering   +7 more
doaj   +1 more source

Viral Hepatitis - The Road Traveled and the Journey Remaining

Hepatic Medicine: Evidence and Research, 2022
Ghulam Fareed Malik,1 Noval Zakaria,1 Muhammad Ibrahim Majeed,2 Faisal Wasim Ismail1 1Section of Gastroenterology, Department of Medicine, The Aga Khan University, Karachi, Pakistan; 2Medical College, The Aga Khan University, Karachi ...
Malik GF, Zakaria N, Majeed MI, Ismail FW   +3 more
doaj  

Aetiology and Clinical Profile of Infectious Causes of Febrile Jaundice at a Tertiary Care Hospital in Eastern Odisha- An Observational Prospective Study [PDF]

Journal of Clinical and Diagnostic Research, 2022
Introduction: Fever with jaundice is one of the most common presentations seen in both outdoor and indoor patients. This manifestation is seen in many individuals infected with hepatotropic viruses (A to E), bacteria, protozoa, fungi, and non ...
Chaitanya Teja Annam, B Rajendra Prasad Rao, Devasi Manoharlal Bakaramji, Ambika Prasad Mohanty   +3 more
doaj   +1 more source

Protective efficacy of serially up-ranked subdominant CD8+ T cell epitopes against virus challenges.

PLoS Pathogens, 2011
Immunodominance in T cell responses to complex antigens like viruses is still incompletely understood. Some data indicate that the dominant responses to viruses are not necessarily the most protective, while other data imply that dominant responses are ...
Eung-Jun Im, Jessie P Hong, Yaowaluck Roshorm, Anne Bridgeman, Sven Létourneau, Peter Liljeström, Mary Jane Potash, David J Volsky, Andrew J McMichael, Tomáš Hanke   +9 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source