Results 61 to 70 of about 95,991 (217)

Attacking the public health crisis of hepatocellular carcinoma at its roots

Hepatology, EarlyView., 2022
Abstract As the third most common cause of cancer‐related death worldwide with significant mortality rates in the United States, hepatocellular carcinoma has strong association with cirrhosis and chronic hepatitis B virus (HBV) with a growing at‐risk population from the rise in chronic liver disease from alcohol use and nonalcoholic fatty liver disease.
Hannah M. Lee, Steven D. Lidofsky, Tamar H. Taddei, Lisa J. Townshend‐Bulson   +3 more
wiley   +1 more source

Oncogenic viruses rewire the epigenome in human cancer

Frontiers in Cellular and Infection Microbiology
Viruses contribute to approximately 15–20% of global cancer cases, yet the full spectrum of their oncogenic mechanisms continues to be uncovered. Beyond the classical roles of genome integration, chronic inflammation, and immune evasion, mounting ...
Jhommara Bautista, Jhommara Bautista, Jhommara Bautista, Andrés Lopez-Cortes   +3 more
doaj   +1 more source

The Evolutionary Arms Race between Virus and NK Cells: Diversity Enables Population-Level Virus Control

Viruses, 2019
Viruses and natural killer (NK) cells have a long co-evolutionary history, evidenced by patterns of specific NK gene frequencies in those susceptible or resistant to infections.
Sarah K. A. Savoy, Jeanette E. Boudreau   +1 more
doaj   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

DNA Nanoarray for Multiplexed RNA Detection With Single‐Molecule Readout

Advanced Science, EarlyView.
A carrier‐based DNA nanoarray integrates programmable nucleic acid hybridization with solid‐state nanopore readout for direct RNA detection at single‐molecule resolution. A ternary encoding system enables 27 carriers with 81 addressable sensing sites, allowing the simultaneous identification of targets spanning a wide size range, from short microRNAs ...
Yunxuan Li, Yesheng Wang, Chunmiao Yu, Siyu Hou, Elli Mylona, Plamena Naydenova, Jingyuan Zhao, Hong Yuan, Jingsong Duan, Hendrik F. P. Runge, Stephen Baker, Jinbo Zhu, Ulrich F. Keyser   +12 more
wiley   +1 more source

Health disparities in chronic liver disease

Hepatology, EarlyView., 2022
Abstract The syndemic of hazardous alcohol consumption, opioid use, and obesity has led to important changes in liver disease epidemiology that have exacerbated health disparities. Health disparities occur when plausibly avoidable health differences are experienced by socially disadvantaged populations.
Ani Kardashian, Marina Serper, Norah Terrault, Lauren D. Nephew   +3 more
wiley   +1 more source

Características epidemiológicas de la hepatitis C en donantes de sangre

Revista Cubana de Higiene y Epidemiología
Se presentó un estudio de casos y controles (60 y 120 respectivamente) en donantes de sangre del Banco Provincial de Cienfuegos. Los casos fueron aquellos que se identificaron como positivos en la prueba de detección de anticuerpos contra el virus C de ...
Domingo Sabina Molina, Francisco García Valdés, Álvaro Asconegui Moya, Orelvis Martínez López   +3 more
doaj  

Comportamiento de la Hepatitis C en donantes de sangre

Revista Cubana de Higiene y Epidemiología, 2001
Se realizó un estudio prospectivo de los donantes habituales de sangre de los bancos municipales de 10 de Octubre y Guanabacoa durante el año 1999, donde se encontraron 50 pacientes con el antígeno C positivo para la hepatitis.
Marcia Almuiña Güemes, Oscar Alonso Chil, Aymee Vera Estévez, Carlos Villegas Valverde   +3 more
doaj  

Hepatic differentiation of human pluripotent stem cells in miniaturized format suitable for high-throughput screen

Stem Cell Research, 2016
The establishment of protocols to differentiate human pluripotent stem cells (hPSCs) including embryonic (ESC) and induced pluripotent (iPSC) stem cells into functional hepatocyte-like cells (HLCs) creates new opportunities to study liver metabolism ...
Arnaud Carpentier, Ila Nimgaonkar, Virginia Chu, Yuchen Xia, Zongyi Hu, T. Jake Liang   +5 more
doaj   +1 more source

Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

Advanced Science, EarlyView.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng, Diguang Wen, Lu Zeng, Lin Lv, Shengtao Liao, Wenguang Zhang, Zhechuan Mei, Chuanfei Li   +7 more
wiley   +1 more source