Results 41 to 50 of about 1,015,430 (313)

Neutralisation resistance of SARS-CoV-2 spike-variants is primarily mediated by synergistic receptor binding domain substitutions

Emerging Microbes and Infections
The evolution of SARS-CoV-2 has led to the emergence of numerous variants of concern (VOCs), marked by changes in the viral spike glycoprotein, the primary target for neutralising antibody (nAb) responses. Emerging VOCs, particularly omicron sub-lineages,
Long V. Pham, Alexander P. Underwood, Alekxander Binderup, Ulrik Fahnøe, Carlota Fernandez-Antunez, Blanca Lopez-Mendez, Line Abildgaard Ryberg, Andrea Galli, Christina Sølund, Nina Weis, Santseharay Ramirez, Jens Bukh   +11 more
doaj   +1 more source

Hepatitis C-vírus-fertőzés kiújulása májátültetés után. Mi változott az elmúlt 10 évben? [PDF]

, 2014
Introduction: Management of hepatitis C virus recurrence is a challenge after liver transplantation. Aim: The aim of the authors was to analyse the outcome of liver transplantation performed in hepatitis C virus positive patients during the past ten ...
Doros, Attila, Fazakas, János, Fehérvári, Imre, Gelley, Fanni, Gerlei, Zsuzsanna, Gámán, György, Görög, Dénes, Kiss, András, Kóbori, László, Lengyel, Gabriella, Nagy, Péter, Nemes Balázs Áron (1969-) (sebész), Nemes Balázs Áron (1969-) (sebész), Nemes Balázs Áron (1969-) (sebész), Nemes, Balázs, Schaff, Zsuzsa, Schuller, János, Szőnyi, László, Sárváry, Enikő, Zádori, Gergely   +19 more
core   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

The significance of m6A RNA methylation regulators in predicting the prognosis and clinical course of HBV-related hepatocellular carcinoma

Molecular Medicine, 2020
Background Hepatocarcinogenesis is reportedly correlated with abnormal m6A modifications; however, it is unknown whether m6A RNA methylation regulators facilitate the occurrence of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC).
Qiongxuan Fang, Hongsong Chen
doaj   +1 more source

Characteristic gene expression in the liver monocyte-macrophage-DC system is associated with the progression of fibrosis in NASH

Frontiers in Immunology, 2023
BackgroundThe monocyte-macrophage-dendritic cell (DC) (MMD) system exerts crucial functions that may modulate fibrogenesis in nonalcoholic steatohepatitis (NASH).
Xiaoxiao Wang, Zilong Wang, Baiyi Liu, Rui Jin, Yuyun Song, Ran Fei, Xu Cong, Rui Huang, Xiaohe Li, Jia Yang, Lai Wei, Huiying Rao, Feng Liu   +12 more
doaj   +1 more source

Liver disease in chelated transfusion-dependent thalassemics: the role of iron overload and chronic hepatitis C. [PDF]

, 2008
Iron overload and hepatitis virus C infection cause liver fibrosis in thalassemics. In a monocentric retrospective analysis of liver disease in a cohort of 191 transfusion-dependent thalassemics, in 126 patients who had undergone liver biopsy (mean age ...
ALMASIO, Pier Luigi, BARBARIA, F, BORSELLINO, Z, BRONTE, Fabrizio, CABIBI, Daniela, CAPRA, M, CRAXI, Antonio, CUCCIA, L, DI MARCO, Vito, DI STEFANO, Rosa, FERRARO, Donatella, GAGLIARDOTTO, F, RUFFO, GB   +12 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Peer-Delivered Hepatitis C Testing and Health Screening Provided in a Community Pharmacy Setting: Proof of Concept

Pharmacy
In order to reach and maintain hepatitis C virus (HCV) elimination goals, it is imperative to reach marginalized people who do not engage with traditional testing and treatment. Peer-led interventions are effective in engaging such individuals.
Neha Sankla, Ray Cottington, Chris Cowie, Paul Huggett, Leila Reid, Stuart Smith, Sorcha Daly, Danny Morris, James Spear, Amanda Marsden, David Richards, Rachel Halford, Scott Walter, Jenny Scott   +13 more
doaj   +1 more source

Novel HCV Genotype 4d Infectious Systems and Assessment of Direct-Acting Antivirals and Antibody Neutralization

Viruses, 2022
Hepatitis C virus (HCV) genotype 4 is highly prevalent in the Middle East and parts of Africa. Subtype 4d has recently spread among high-risk groups in Europe.
Long V. Pham, Rodrigo Velázquez-Moctezuma, Ulrik Fahnøe, Laura Collignon, Priyanka Bajpai, Christina Sølund, Nina Weis, Kenn Holmbeck, Jannick Prentoe, Jens Bukh   +9 more
doaj   +1 more source

Era of direct acting anti-viral agents for the treatment of hepatitis C. [PDF]

, 2018
Hepatitis C infection is universal and the most common indication of liver transplantation in the United States. The period of less effective interferon therapy with intolerable side effects has gone.
Ahmed, Monjur
core   +1 more source