Results 1 to 10 of about 346,794 (205)
, 2013 Hepatitis C virus (HCV) is a hepatotropic virus and a major cause of chronic hepatitis and liver disease worldwide. Initial interactions between HCV virions and hepatocytes are required for productive viral infection and initiation of the viral life cycle.
Daniel J. Felmlee +4 more
openaire +4 more sources
An update on hepatitis C virus [PDF]
Clinical Medicine, 2015 Chronic hepatitis caused by hepatitis C virus infection is one of the leading causes of liver cirrhosis and hepatocellular carcinoma globally. Over the last few years, there have been significant advances in our understanding of the immunopathogenesis of this infection, as well as revolutionary developments in the therapeutic armamentarium.
Klenerman, P, Fitzmaurice, K
openaire +4 more sources
Hepatitis C virus and autoimmunity [PDF]
Autoimmunity Highlights, 2010 Hepatitis C virus infection is associated with several extrahepatic manifestations. About 60% of patients infected with HCV develop at least one extrahepatic manifestation. The majority of these diseases seem to be triggered through autoimmune mechanisms, such as autoantibody production, autoreactive T cells and complex autoimmune mechanisms leading to
N Sepp, Barbara C. Böckle
openaire +2 more sources
Brazilian Journal of Infectious Diseases, 2014 Aim: To evaluate changes in liver histology in patients with human immunodeficiency virus/hepatitis C virus coinfection non-responders to a suboptimal Interferon + Ribavirine regimen. Materials and methods: We investigated 49 patients with two sequential
Caterina Sagnelli +8 more
doaj +1 more source
Hepatitis C virus and hepatocarcinogenesis
Clinical and Molecular Hepatology, 2012 Hepatitis C virus (HCV) is an RNA virus that is unable to integrate into the host genome. However, its proteins interact with various host proteins and induce host responses. The oncogenic process of HCV infection is slow and insidious and probably requires multiple steps of genetic and epigenetic alterations, the activation of cellular oncogenes, the ...
Jeong, Soung Won +2 more
openaire +5 more sources
Brazilian Journal of Infectious Diseases, 2013 Objective: To evaluate the influence of hepatitis C virus on immunological and virological responses after highly active antiretroviral therapy initiation in human immunodeficiency virus/hepatitis C virus coinfected patients compared to monoinfected ...
Vicente Sperb Antonello +4 more
doaj +3 more sources
Case Reports in Gastroenterology, 2016 Following interferon-based therapy for chronic hepatitis C, the negativity of hepatitis C virus RNA is essential to achieve viral clearance at the end of treatment.
Akira Sato +5 more
doaj +1 more source
Hepatitis C Virus and Cardiomyopathy [PDF]
Herz, 2000 The importance of hepatitis C virus infection has been recently noted in patients with hypertrophic cardiomyopathy or dilated cardiomyopathy. In a collaborative research project of the Committees for the Study of Idiopathic Cardiomyopathy, hepatitis C virus antibody was found in 74 of 697 patients (10.6%) with hypertrophic cardiomyopathy and in 42 of ...
openaire +5 more sources
AJPM Focus, 2023 Introduction: Hepatitis C virus is associated with high morbidity and mortality—chronic liver disease is a leading cause of death among Latinos in the U.S.
Brian L. Chan, MD, MPH +8 more
doaj +1 more source
Hepatitis C virus and the kidney
Nature Reviews Nephrology, 2018 Hepatitis C virus (HCV) infection is more prevalent and is associated with higher mortality in patients receiving dialysis and in kidney transplant recipients than in the general population. Kidney transplant recipients who are HCV-positive are also at higher risk of allograft and liver failure than are HCV-negative recipients.
Pol, Stanislas +2 more
openaire +4 more sources