Results 1 to 10 of about 521,843 (47)

Global epidemiology of hepatitis C virus infection: New estimates of age‐specific antibody to HCV seroprevalence

Hepatology, 2013
In efforts to inform public health decision makers, the Global Burden of Diseases, Injuries, and Risk Factors 2010 (GBD2010) Study aims to estimate the burden of disease using available parameters.
K. Mohd Hanafiah, J. Groeger, A. Flaxman, S. Wiersma   +3 more
semanticscholar   +1 more source

Telaprevir for previously untreated chronic hepatitis C virus infection.

New England Journal of Medicine, 2011
BACKGROUND In phase 2 trials, telaprevir, a hepatitis C virus (HCV) genotype 1 protease inhibitor, in combination with peginterferon-ribavirin, as compared with peginterferon-ribavirin alone, has shown improved efficacy, with potential for shortening the
I. Jacobson, J. Mchutchison, G. Dusheiko, A. Bisceglie, K. Reddy, N. Bzowej, P. Marcellin, A. Muir, P. Ferenci, R. Flisiak, J. George, M. Rizzetto, D. Shouval, R. Solá, R. Terg, E. Yoshida, N. Adda, L. Bengtsson, A. Sankoh, Tara L. Kieffer, S. George, R. Kauffman, S. Zeuzem, V. Phar   +23 more
semanticscholar   +1 more source

The prevalence of hepatitis C virus infection in the United States, 1988 through 1994.

New England Journal of Medicine, 1999
BACKGROUND Because many persons with chronic hepatitis C virus (HCV) infection are asymptomatic, population-based serologic studies are needed to estimate the prevalence of the infection and to develop and evaluate prevention efforts.
M. J. Alter, D. Kruszon-Moran, O. Nainan, G. Mcquillan, Fengxiang Gao, L. Moyer, Richard A. Kaslow, H. Margolis   +7 more
semanticscholar   +1 more source

Global Distribution and Prevalence of Hepatitis C Virus Genotypes

Hepatology, 2014
Hepatitis C virus (HCV) exhibits high genetic diversity, characterized by regional variations in genotype prevalence. This poses a challenge to the improved development of vaccines and pan‐genotypic treatments, which require the consideration of global ...
J. Messina, I. Humphreys, A. Flaxman, A. Brown, G. Cooke, O. Pybus, E. Barnes   +6 more
semanticscholar   +1 more source

Hepatitis C guidance: AASLD‐IDSA recommendations for testing, managing, and treating adults infected with hepatitis C virus

Hepatology, 2015
The pace of hepatitis C virus (HCV) drug development in recent years has accelerated dramatically. For patients to benefit from these impressive advances, practitioners need access to the most up-to-date data and to advice from experienced experts.
Aasld Idsa Hcv Guidance Panel
semanticscholar   +1 more source

Complete Replication of Hepatitis C Virus in Cell Culture

Science, 2005
Many aspects of the hepatitis C virus (HCV) life cycle have not been reproduced in cell culture, which has slowed research progress on this important human pathogen.
B. Lindenbach, M. Evans, A. Syder, B. Wölk, T. Tellinghuisen, Christopher C. Liu, T. Maruyama, R. Hynes, D. Burton, J. McKeating, C. Rice   +10 more
semanticscholar   +1 more source

Genetic variation in IL28B and spontaneous clearance of hepatitis C virus

Nature, 2009
Hepatitis C virus (HCV) infection is the most common blood-borne infection in the United States, with estimates of 4 million HCV-infected individuals in the United States and 170 million worldwide.
David L. Thomas, C. Thio, Maureen P. Martin, Y. Qi, D. Ge, C. O’hUigin, J. Kidd, K. Kidd, S. Khakoo, G. Alexander, J. Goedert, G. Kirk, S. Donfield, H. Rosen, L. Tobler, M. Busch, J. Mchutchison, D. Goldstein, M. Carrington   +18 more
semanticscholar   +1 more source

Global epidemiology of hepatitis C virus infection: An up-date of the distribution and circulation of hepatitis C virus genotypes

World Journal of Gastroenterology, 2016
AIM To review Hepatitis C virus (HCV) prevalence and genotypes distribution worldwide. METHODS We conducted a systematic study which represents one of the most comprehensive effort to quantify global HCV epidemiology, using the best available published ...
A. Petruzziello, Samantha Marigliano, Giovanna Loquercio, A. Cozzolino, C. Cacciapuoti   +4 more
semanticscholar   +1 more source

Modulation of Hepatitis C Virus RNA Abundance by a Liver-Specific MicroRNA

Science, 2005
MicroRNAs are small RNA molecules that regulate messenger RNA (mRNA) expression. MicroRNA 122 (miR-122) is specifically expressed and highly abundant in the human liver.
C. Jopling, M. Yi, Alissa M. Lancaster, S. Lemon, P. Sarnow   +4 more
semanticscholar   +1 more source

Hepatitis C Guidance 2019 Update: American Association for the Study of Liver Diseases–Infectious Diseases Society of America Recommendations for Testing, Managing, and Treating Hepatitis C Virus Infection

Hepatology, 2019
The American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) initiated the hepatitis C guidance project (hereafter HCV guidance) in 2013. The AASLD-IDSA HCV guidance website (www.HCVGuidelines.org)
M. Ghany, Kristen M. Marks, Timothy R. Morgan, D. Wyles, A. Aronsohn, D. Bhattacharya, Tina Broder, Oluwaseun O Falade-Nwulia, Jordan J. Feld, Stuart C Gordon, Theo Heller, Ravi R Jhaveri, Maureen M Jonas, Jennifer J Kiser, B. Linas, Vincent Lo Re, Marion G Peters, K. R. Reddy, Andrew Reynolds, John D Scott, Gloria Searson, P. Spradling, Norah A. Terrault, Stacey B. Trooskin, E. Verna, John B Wong, A. Woolley, K. A. Workowski   +27 more
semanticscholar   +1 more source