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Hepatitis C virus (HCV) is an enveloped, RNA virus transmitted through blood-to-blood contact. It infects humans only and primarily targets liver cells. HCV evades innate and adaptive immunity and establishes chronic infections in 70% of cases. If untreated, 20% of patients develop liver cirrhosis, and a fraction of these progress to hepatocellular ...
Pietschmann, Thomas, Brown, Richard J P
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HepCV is the major cause of NANB PT hepatitis and is also implicated as the cause in a large proportion of sporadic cases of NANBH. Chronic infection with HepCV has also been linked to the development of hepatocellular carcinoma. Chimpanzees and marmosets are the only animals found to be experimentally infectable and the virus has not been propagated ...
Christine A. Lee, C Pereira, G Dusheiko
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Recombination in Hepatitis C Virus [PDF]
Hepatitis C virus (HCV) is a Flavivirus with a positive-sense, single-stranded RNA genome of about 9,600 nucleotides. It is a major cause of liver disease, infecting almost 200 million people all over the world. Similarly to most RNA viruses, HCV displays very high levels of genetic diversity which have been used to differentiate six major genotypes ...
Fernando González-Candelas+2 more
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Hepatitis C virus and lymphoma [PDF]
Non ...
Ponzetto, Antonio, Carloni, Guido
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Hepatitis C virus infection [PDF]
Hepatitis C virus (HCV) infection is a major public health problem. Up to 3% of the world's population is infected with HCV, and at least 200 000 adults in the UK carry the virus. Of those exposed to HCV, 80% become chronically infected, and at least 30% of carriers develop chronic liver disease, including cirrhosis and hepatocellular carcinoma.
Roger Finch, B.J. Thomson
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The prevalence of hepatitis C virus infection in the United States, 1988 through 1994.
BACKGROUND Because many persons with chronic hepatitis C virus (HCV) infection are asymptomatic, population-based serologic studies are needed to estimate the prevalence of the infection and to develop and evaluate prevention efforts.
M. J. Alter+7 more
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Liver disease in chelated transfusion-dependent thalassemics: the role of iron overload and chronic hepatitis C. [PDF]
Iron overload and hepatitis virus C infection cause liver fibrosis in thalassemics. In a monocentric retrospective analysis of liver disease in a cohort of 191 transfusion-dependent thalassemics, in 126 patients who had undergone liver biopsy (mean age ...
ALMASIO, Pier Luigi+12 more
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Hepatitis C Virus Treatment in Children: A Challenge for Hepatitis C Virus Elimination [PDF]
AbstractHepatitis C is a global public health threat. The introduction of direct-acting antivirals (DAAs) brings the prospect of curing the 71 million people living with the disease, dramatically changing the landscape of hepatitis C. The World Health Organization developed a roadmap for the elimination and cure of hepatitis C by 2030 with a clear goal
El-Sayed, Manal H, Indolfi, Giuseppe
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Introduction: End stage renal disease (ESRD) has become a universal public health problem. Chronic kidney disease (CKD) is immune deficient state. So, they may be infected with hepatitis B virus (HBV) and hepatitis C virus (HCV) during hemodialysis. This
Pragya, Anil Kumar, Sreedhar
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Global Distribution and Prevalence of Hepatitis C Virus Genotypes
Hepatitis C virus (HCV) exhibits high genetic diversity, characterized by regional variations in genotype prevalence. This poses a challenge to the improved development of vaccines and pan‐genotypic treatments, which require the consideration of global ...
J. Messina+6 more
semanticscholar +1 more source