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Microbiologia Medica, 2016 Background and aims: Hepatitis C virus (HCV) represents a major worldwide public health problem requiring global action for the diagnosis, treatment and prevention of this infection.
Sara Salvetti +2 more
doaj +1 more source
, 2013 Hepatitis C virus (HCV) is a hepatotropic virus and a major cause of chronic hepatitis and liver disease worldwide. Initial interactions between HCV virions and hepatocytes are required for productive viral infection and initiation of the viral life cycle.
Daniel J. Felmlee +4 more
openaire +4 more sources
Hepatitis C virus and autoimmunity [PDF]
Autoimmunity Highlights, 2010 Hepatitis C virus infection is associated with several extrahepatic manifestations. About 60% of patients infected with HCV develop at least one extrahepatic manifestation. The majority of these diseases seem to be triggered through autoimmune mechanisms, such as autoantibody production, autoreactive T cells and complex autoimmune mechanisms leading to
N Sepp, Barbara C. Böckle
openaire +2 more sources
Brazilian Journal of Infectious Diseases, 2014 Aim: To evaluate changes in liver histology in patients with human immunodeficiency virus/hepatitis C virus coinfection non-responders to a suboptimal Interferon + Ribavirine regimen. Materials and methods: We investigated 49 patients with two sequential
Caterina Sagnelli +8 more
doaj +1 more source
World Journal of Gastroenterology, 2016 AIM To review Hepatitis C virus (HCV) prevalence and genotypes distribution worldwide. METHODS We conducted a systematic study which represents one of the most comprehensive effort to quantify global HCV epidemiology, using the best available published ...
A. Petruzziello +4 more
semanticscholar +1 more source
Hepatitis C virus and hepatocarcinogenesis
Clinical and Molecular Hepatology, 2012 Hepatitis C virus (HCV) is an RNA virus that is unable to integrate into the host genome. However, its proteins interact with various host proteins and induce host responses. The oncogenic process of HCV infection is slow and insidious and probably requires multiple steps of genetic and epigenetic alterations, the activation of cellular oncogenes, the ...
Jeong, Soung Won +2 more
openaire +5 more sources
Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
Nature, 2009 Hepatitis C virus (HCV) infection is the most common blood-borne infection in the United States, with estimates of 4 million HCV-infected individuals in the United States and 170 million worldwide.
David L. Thomas +18 more
semanticscholar +1 more source
Brazilian Journal of Infectious Diseases, 2013 Objective: To evaluate the influence of hepatitis C virus on immunological and virological responses after highly active antiretroviral therapy initiation in human immunodeficiency virus/hepatitis C virus coinfected patients compared to monoinfected ...
Vicente Sperb Antonello +4 more
doaj +3 more sources
Canadian Medical Association Journal, 2015 Hepatitis C virus (HCV) results in more lost years of life and more illness than any infectious disease in Ontario.[1][1] Screening individuals born between 1945 and 1965 using an anti-HCV antibody test is currently recommended in the United States.[2][2]
Michael Fralick, J. Feld
semanticscholar +1 more source
Case Reports in Gastroenterology, 2016 Following interferon-based therapy for chronic hepatitis C, the negativity of hepatitis C virus RNA is essential to achieve viral clearance at the end of treatment.
Akira Sato +5 more
doaj +1 more source