Hepatitis C Virus Resistance to Direct-Acting Antiviral Drugs in Interferon-Free Regimens.
Gastroenterology, 2016 Treatment of hepatitis C virus (HCV) infection has progressed considerably with the approval of interferon-free, direct-acting antiviral (DAA)-based combination therapies.
J. Pawlotsky
semanticscholar +1 more source
Simultaneous reconstruction of evolutionary history and epidemiological dynamics from viral sequences with the birth-death SIR model [PDF]
J. R. Soc. Interface 2014 11, 20131106, published 26 February 2014, 2013 The evolution of RNA viruses such as HIV, Hepatitis C and Influenza virus occurs so rapidly that the viruses' genomes contain information on past ecological dynamics. Hence, we develop a phylodynamic method that enables the joint estimation of epidemiological parameters and phylogenetic history.
arxiv +1 more source
Evolving epidemiology of hepatitis C virus.
Clinical Microbiology and Infection, 2011 More than 20 years after the discovery of the hepatitis C virus (HCV), it is now well established that HCV is of global importance affecting all countries, leading to a major global health problem that requires widespread active interventions for its ...
D. Lavanchy
semanticscholar +1 more source
Status of Direct-Acting Antiviral Therapy for Hepatitis C Virus Infection and Remaining Challenges.
Gastroenterology, 2019 Chronic infection with hepatitis C virus is a major cause of liver disease and hepatocellular carcinoma worldwide. After the discovery of hepatitis C virus 3 decades ago, the identification of the structure of the viral proteins, combined with high ...
T. Baumert +3 more
semanticscholar +1 more source
Global analysis of a spatiotemporal cellular model for the transmission of hepatitis C virus with Hattaf-Yousfi functional response [PDF]
arXiv, 2021 In this paper, a mathematical analysis of the global dynamics of a partial differential equation viral infection cellular model is carried out. We study the dynamics of a hepatitis C virus (HCV) model, under therapy, that considers both absorption phenomenon and diffusion of virions, infected and uninfected cells in liver. Firstly, we prove boundedness
arxiv
A network model for the propagation of Hepatitis C with HIV co-infection [PDF]
J. Stat. Mech. (2017) 053205, 2017 We define and examine a model of epidemic propagation for a virus such as Hepatitis C (with HIV co-infection) on a network of networks, namely the network of French urban areas. One network level is that of the individual interactions inside each urban area.
arxiv +1 more source
Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection
Science, 2010 Anti-MicroRNA Antiviral MicroRNAs (miRNAs) are small noncoding RNAs found in eukaryotes and viruses. They are critical regulators of a wide range of cellular processes.
R. Lanford +7 more
semanticscholar +1 more source
Journal of Infectious Diseases, 2018 Background Hepatitis C virus (HCV) exhibits great genetic diversity and is classified into 7 genotypes (GTs), with varied geographic prevalence. Until the recent development of pangenotypic direct-acting antiviral regimens, the determination of HCV GT ...
S. Borgia +10 more
semanticscholar +1 more source
The context-specificity of virulence evolution revealed through evolutionary invasion analysis [PDF]
arXiv, 2023 Models are often employed to integrate knowledge about epidemics across scales and simulate disease dynamics. While these approaches have played a central role in studying the mechanics underlying epidemics, we lack ways to reliably predict how the relationship between virulence (the harm to hosts caused by an infection) and transmission will evolve in
arxiv
Hepatitis C virus: Morphogenesis, infection and therapy
World Journal of Hepatology, 2018 Hepatitis C virus (HCV) is a major cause of liver diseases including liver cirrhosis and hepatocellular carcinoma. Approximately 3% of the world population is infected with HCV. Thus, HCV infection is considered a public healthy challenge.
V. Morozov, S. Lagaye
semanticscholar +1 more source