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Glecaprevir/pibrentasvir is approved to treat hepatitis C virus genotype 1–6 infection. Patients coinfected with human immunodeficiency virus type 1 achieved high cure rates after 8- (without cirrhosis) and 12- (compensated cirrhosis) week treatment ...
J. Rockstroh+21 more
semanticscholar +1 more source
Mathematical Model and Analysis of Transmission Dynamics of Hepatitis B Virus [PDF]
Hepatitis B is a potentially life-threatening liver infection caused by the hepatitis B virus (HBV). In this paper, the transmission dynamics of hepatitis B is formulated with a mathematical model with considerations of different classes of individuals, namely immunized, susceptible, latent,infected and recovered class.
arxiv
Model Based Framework for Estimating Mutation Rate of Hepatitis C Virus in Egypt [PDF]
Hepatitis C virus (HCV) is a widely spread disease all over the world. HCV has very high mutation rate that makes it resistant to antibodies. Modeling HCV to identify the virus mutation process is essential to its detection and predicting its evolution.
arxiv
Hepatitis C Virus Epidemic Control Using a Nonlinear Adaptive Strategy [PDF]
Hepatitis C is a viral infection that appears as a result of the Hepatitis C Virus (HCV), and it has been recognized as the main reason for liver diseases. HCV incidence is growing as an important issue in the epidemiology of infectious diseases. In the present study, a mathematical model is employed for simulating the dynamics of HCV outbreak in a ...
arxiv
Robust hepatitis C virus infection in vitro.
The absence of a robust cell culture model of hepatitis C virus (HCV) infection has severely limited analysis of the HCV life cycle and the development of effective antivirals and vaccines. Here we report the establishment of a simple yet robust HCV cell
Jin Zhong+9 more
semanticscholar +1 more source
Extrahepatic manifestations of chronic hepatitis C virus infection
During hepatitis C virus (HCV) chronic infection, extrahepatic manifestations are frequent and polymorphous. This article reports on a large cohort of patients with HCV-related autoimmune or lymphoproliferative disorders, from mixed cryoglobulinemia ...
P. Cacoub+5 more
semanticscholar +1 more source
Modeling the dynamics of Hepatitis C Virus with combined antiviral drug therapy: Interferon and Ribavirin [PDF]
A mathematical modeling of Hepatitis C Virus (HCV) dynamics has been presented in this paper. The proposed model, which involves four coupled ordinary differential equations, describes the interaction of target cells (hepatocytes), infected cells, infectious virions and non-infectious virions.
arxiv
Nipah virus vector sequences in COVID-19 patient samples sequenced by the Wuhan Institute of Virology [PDF]
We report the detection of Nipah virus in an infectious clone format, a BSL4-level pathogen and CDC-designated Bioterrorism Agent, in raw RNA-Seq sequencing reads deposited by the Wuhan Institute of Virology (WIV) produced from five December 2019 patients infected with SARS-CoV-2.
arxiv
Hepatitis C Virus and Hepatocellular Carcinoma: A Narrative Review
Hepatocellular carcinoma (HCC) is a leading cause of liver-related death worldwide. Hepatitis C virus (HCV) infection is a major cause of advanced hepatic fibrosis and cirrhosis, with significantly increased risk for development of HCC. The morbidity and
Page Axley+3 more
semanticscholar +1 more source
Influence of Intracellular Delay on the Dynamics of Hepatitis C Virus [PDF]
In this paper we present a delay induced model for hepatitis C virus incorporating the healthy and infected hepatocytes as well as infectious and noninfectious virions. The model is mathematically analyzed and characterized, both for the steady states and the dynamical behavior of the model.
arxiv