Results 81 to 90 of about 911,773 (309)

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source

Seroprevalence of hepatitis E virus in chronic hepatitis C in Brazil

Brazilian Journal of Infectious Diseases, 2018
Background and aims: Hepatitis E virus infection in patients with underlying chronic liver disease is associated with liver decompensation and increased lethality.
Guilherme Bricks, Jorge Figueiredo Senise, Henrique Pott Junior, Giuliano Grandi, Amanda Passarini, Débora Bellini Caldeira, Dimas Carnaúba Junior, Hamilton Antonio Bonilha de Moraes, Celso Franscisco Hernandes Granato, Adauto Castelo   +9 more
doaj   +1 more source

Genome‐Wide CRISPR Screen Reveals PIK3CA Inhibition Enhances Lipid Nanoparticle‐Mediated siRNA Delivery

Advanced Science, EarlyView.
A genome‐wide CRISPR screen and identifies PIK3CA as a key regulator of lipid nanoparticle (LNP) uptake is performed. Modulating PIK3CA with small‐molecule inhibitor BAY1082439 enhanced LNP uptake, siRNA delivery, and gene silencing in a variety of epithelial cells, and improved therapeutic outcomes in vivo.
Wenhan Wang, Kangfu Chen, Zongjie Wang
wiley   +1 more source

Hepatocyte BPGM Induces RET Lactylation and Macrophage Reprogramming to Promote Tumorigenesis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Mechanistic schematic diagram.BPGM promotes the expression level of RET by increasing the lactylation of RET‐K549 and inhibiting its ubiquitination levels in HCC cells. Furthermore, BPGM in HCC cells could also promote M2 polarization in macrophages through lactate secretion. Both of the mechanisms could promote the progression of HCC. ABSTRACT Aerobic
Jiajia Zhang, Lu Shi, Liangliang Lin, Yang Zhang, Miao Zhang, Lili Wu, Yong Xia, Yaqiong Zhang, Peng Han, Likun Zhuang, Liang Shi   +10 more
wiley   +1 more source

Solution Structure of Substrate-based Ligands When Bound to Hepatitis C Virus NS3 Protease Domain [PDF]

, 1999
Steven R. LaPlante, Dale R. Cameron, Norman Aubry, Sylvain Lefèbvre, George Kukolj, Roger Maurice, Diane Thibeault, Daniel Lamarre, Montse Llinàs‐Brunet   +8 more
openalex   +1 more source

Engineered Small Extracellular Vesicles Targeting Tumor‐Associated Endothelial Cells to Effectively Remodel the Glioma Microenvironment

Advanced Science, EarlyView.
This study developed a novel drug delivery platform that overcomes the blood‐brain barrier in glioblastoma. By fusing IGFBP7 with small extracellular vesicles, the platform specifically targets tumor vasculature. It effectively delivers temozolomide, suppressing tumor growth at low doses.
Lingling Liu, Feiyang Xu, Zhiming Zheng, Xiaodan Yang, Fang Yang, Pei Liu, Yuankun Chen, Yunshu Yang, Junli Zhao, Peiyan Yang, Xiaojing Zheng, Xiaohong Sun, Ping Mao, Qinwen Mao, Hao Guan, Haibin Xia, Weifeng Zhang, Dan Xiao   +17 more
wiley   +1 more source

Hepatitis C III. Estudio laparoscópico, histológico y niveles séricos de alanina aminotransferasa en 160 pacientes seropositivos al virus de la hepatitis C Hepatitis C III. Laparoscopic and histological study and serum levels of alanine aminotransferase in 160 HCV seropositive patients

Revista Cubana de Investigaciones Biomédicas, 2005
Se realizó el estudio laparoscópico, histológico y su correlación con el comportamiento de los niveles séricos de alanina aminotransferasa en 160 pacientes seropositivos al virus hepatitis C, que asistieron a la consulta externa del Departamento de ...
Jorge Valdés Moreno, Orlando G Rodríguez del Rey Piña, Lidia Cardellá Rosales   +2 more
doaj  

Hepatitis C, hepatitis B and HIV infection among Egyptian prisoners: Seroprevalence, risk factors and related chronic liver diseases

Journal of Infection and Public Health, 2013
Summary: Background and aim: Prisons in Egypt do not currently screen for blood-borne viruses, and there are no statistics concerning the prevalence of hepatitis C virus, hepatitis B virus or human immunodeficiency virus among prisoners.
Hala I. Mohamed, Zienab M. Saad, Ehab M. Abd-Elreheem, Wael M. Abd-ElGhany, Mohamed S. Mohamed, Emad A. Abd Elnaeem, Amany E. Seedhom   +6 more
doaj   +1 more source

Human immunodeficiency virus, hepatitis C, and inflammatory biomarkers in individuals with alcohol problems: a cross-sectional study [PDF]

, 2013
Kaku So‐Armah, Emily Quinn, Debbie M. Cheng, Russell P. Tracy, Jason V. Baker, Jeffrey H. Samet, Matthew S. Freiberg   +6 more
openalex   +1 more source

Prevalence of Hepatitis C Virus Infection Among Blood Donors and Certain Risky Groups in Diyala Province

Diyala Journal of Medicine, 2019
Background: Although the prevalence of hepatitis C virus infection among the general population is generally low; however, the risk of chronic hepatitis C virus infection is still high in certain groups of patients particularly multiple recipients of ...
Nadhim Ghazal Noaman
doaj   +2 more sources