Results 101 to 110 of about 1,000,209 (254)

Hepatitis delta: virological and clinical aspects

Virology Journal, 2017
There are an estimated 400 million chronic carriers of HBV worldwide; between 15 and 20 million have serological evidence of exposure to HDV. Traditionally, regions with high rates of endemicity are central and northern Africa, the Amazon Basin, eastern ...
L. F. Botelho-Souza, M. Vasconcelos, Alcione de Oliveira dos Santos, J. M. Salcedo, D. Vieira   +4 more
semanticscholar   +1 more source

Assessing Major Adverse Liver Outcomes With Baclofen Compared to Acamprosate in Compensated Alcohol‐Associated Cirrhosis

Alimentary Pharmacology &Therapeutics, EarlyView.
We conducted a nationwide, multicenter cohort study using a target trial emulation framework to compare baclofen and acamprosate in patients with compensated alcohol‐associated cirrhosis. After matching, baclofen initiation was associated with a higher 1‐year risk of major adverse liver outcomes, driven primarily by hepatic encephalopathy, particularly
Yee Hui Yeo, Sepideh Mehravar, Ellen Choi, Ju Dong Yang, Hyun‐Seok Kim, Yun Wang, Aarshi Vipani, Hirsh D. Trivedi, Walid Ayoub, Parnian Naji, Alexander Kuo, Chun‐Ying Wu, Lorenzo Leggio, Juan Pablo Arab   +13 more
wiley   +1 more source

Bulevirtide in the Treatment of Hepatitis Delta: Drug Discovery, Clinical Development and Place in Therapy

Drug Design, Development and Therapy, 2023
Vicente Soriano,1 Victor Moreno-Torres,1,2 Ana Treviño,1 Octavio Corral,1 Carmen de Mendoza2 1Health Sciences School & Medical Center, Universidad Internacional La Rioja (UNIR), Madrid, Spain; 2Puerta de Hierro University Hospital & Research Institute ...
Soriano V, Moreno-Torres V, Treviño A, Corral O, de Mendoza C   +4 more
doaj  

Treosulfan–fludarabine conditioning in infants with severe combined immunodeficiencies: Extended study of the UK paediatric treosulfan study

British Journal of Haematology, EarlyView.
Summary Allogeneic haematopoietic stem cell transplantation (HSCT) is a curative therapy for severe combined immunodeficiency (SCID). Conditioning improves donor engraftment and freedom from immunoglobulin replacement (IgR) but increases the risks of acute and late toxicity. Treosulfan, a reduced toxicity alkylating agent, has emerged as an alternative
Su Han Lum, Sinéad Greener, Irum Latif Memon, Persis Amrolia, Zohreh Nademi, Robert Chiesa, Juliana Silva, Helen Young, Stephen Owens, Eleri Williams, Khuen Foong Ng, Terry Flood, Andrew R Gennery, Sophie Hambleton, Kanchan Rao, Mary Slatter   +15 more
wiley   +1 more source

Prospects for Controlling Hepatitis B Globally

Pathogens
Infection with the hepatitis B virus (HBV) is highly prevalent globally. Over 250 million people suffer from chronic hepatitis B, and more than 800,000 patients die each year due to hepatitis B complications, including liver cancer.
Vicente Soriano, Víctor Moreno-Torres, Ana Treviño, Fernando de Jesús, Octavio Corral, Carmen de Mendoza   +5 more
doaj   +1 more source

The prevalence and impact of brucellosis in patients with hepatitis delta virus infection: inside the Brucella outbreak with cirrhosis

Archives of Medical Science, 2017
Introduction: Hepatitis D virus (HDV) infection is a serious health problem leading to cirrhosis and hepatocellular carcinoma (HCC). Despite evidence that zoonotic infections are associated with end-stage liver disease, brucellosis in patients with ...
Burak Suvak, Ahmet Cumhur Dulger, Ozlem Suvak, Aysun Özel Yesilyurt, Bilge Gultepe, Huseyin Guducuoglu   +5 more
doaj   +1 more source

Checkpoint inhibitors, obinutuzumab plus PET‐adapted ultra‐low dose nodal radiotherapy yield high efficacy in treatment‐naïve follicular lymphoma: Results from the phase II ‘FLUORO’ study

British Journal of Haematology, EarlyView.
Summary Follicular lymphoma (FL) first‐line chemoimmunotherapy yields high efficacy but serious toxicity in 65% of patients. In high tumour burden treatment‐naïve FL, we aimed to exploit known immunostimulatory and cytotoxic properties of combination checkpoint inhibition (atezolizumab) and obinutuzumab (6 cycles) with positron emission tomography (PET)
Arina Martynchyk, Geoffrey Chong, Richard Khor, Denise Lee, Sze Ting Lee, Andrew M. Scott, Anneke C. Grobler, Belinda A. Campbell, Thanuja Thachil, Kate Manos, Genevieve Douglas, Alexandra Romano, Jodie B. Palmer, Melinda Burgess, Colm Keane, Eliza A. Hawkes   +15 more
wiley   +1 more source

Suboptimal Linkage to Care of Delta-Infected Patients in an Area with Increasing Migration-Driven Prevalence of Hepatitis D in Recent Years

Viruses
Background and Aims: Changes in hepatitis delta virus (HDV) epidemiology have been highlighted recently in the context of increasing worldwide migrations.
Ângela Carvalho-Gomes, Ariadna Bono, Lola Gómez, Susana Sabater, Juan Carlos Rodríguez, Antonio Palau, Ana Forés, María Rodríguez, Sonia Pascual, Maria Àngels Cebrià i Iranzo, Martín Prieto, Marina Berenguer   +11 more
doaj   +1 more source

Hepatitis Delta Virus RNA Replication

Viruses, 2009
Hepatitis delta virus (HDV) is a distant relative of plant viroids in the animal world. Similar to plant viroids, HDV replicates its circular RNA genome using a double rolling-circle mechanism.
Chung-Hsin Tseng, Michael M. C. Lai
doaj   +1 more source

Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection

Science Translational Medicine, 2018
An inbred mouse model for HDV infection can be used to study virally induced immune responses and for testing antiviral therapeutics. Diving into hepatitis delta virus Although it is a major burden of hepatitis-related disease, there are no specific ...
Benjamin Y. Winer, E. Shirvani-Dastgerdi, Y. Bram, J. Sellau, B. Low, Heath E Johnson, Tiffany Huang, G. Hrebikova, B. Heller, Yael Sharon, K. Giersch, Sherif Gerges, Kathleen Seneca, Mihai-Alexandru Pais, Angela S. Frankel, L. Chiriboga, J. Cullen, R. Nahass, M. Lutgehetmann, Jared E. Toettcher, M. Wiles, R. Schwartz, A. Ploss   +22 more
semanticscholar   +1 more source