Results 121 to 130 of about 58,225 (243)

Serum‐Based miRNA Panel as Diagnostic Biomarkers for Hepatitis C Virus‐Induced Hepatocellular Carcinoma: A Cross‐Sectional Study

open access: yesHealth Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Hepatocellular carcinoma (HCC) is responsible for more than 90% of primary hepatic cancer. Hepatitis C virus (HCV) infection is one of the contributing factors for HCC development. miRNAs are non‐coding RNAs and are also involved in HCV replication.
Badr Alzahrani   +6 more
wiley   +1 more source

Real‐World Effectiveness of Tolvaptan for Hyponatremia in Cirrhosis Across Global Regions: A Target Trial Emulation

open access: yesJGH Open, Volume 10, Issue 4, April 2026.
ABSTRACT Background Tolvaptan promotes electrolyte‐free water excretion and is widely used in Asia for ascites, but in Western countries its use is limited to hyponatremia because of hepatotoxicity concerns. Methods We performed a retrospective cohort study using the TriNetX Research Network, emulating a target trial of cirrhotic patients with ...
Kazuya Okushin   +5 more
wiley   +1 more source

Therapeutic Impact of Caffeic Acid Phenethyl Ester and Acyclovir Combination on Human Gingival Fibroblasts (HGF‐1) Infected With Herpes Simplex Type 1 ICP0

open access: yesMicrobiologyOpen, Volume 15, Issue 2, April 2026.
ABSTRACT Herpes simplex virus Type 1 (HSV‐1) is a prevalent infectious agent globally, often causing oral infections like gingivostomatitis. The ICP0 protein of HSV‐1 exacerbates infection severity by inhibiting antiviral responses. Our study explored how combinations of CAPE (caffeic acid phenethyl ester) and acyclovir influenced immune responses in ...
Merve Sen, Sefa Celik
wiley   +1 more source

Immunocompromised Status Definition in Observational Studies Using Electronic Health Records: A Scoping Review and a Proposal for a Phenotype Identification Algorithm

open access: yesPharmacoepidemiology and Drug Safety, Volume 35, Issue 4, April 2026.
ABSTRACT Immunocompromised individuals experience an impaired immune function due to conditions that might be either congenital or acquired over the course of their lives. Epidemiological studies often rely on clinical definitions which, in some cases, benefit from being translated into machine‐readable algorithms for application to electronic health ...
Judit Riera‐Arnau   +62 more
wiley   +1 more source

Epidemiology of Viral Hepatitis in the Indigenous Populations of the Arctic Zone of the Republic of Sakha (Yakutia)

open access: yesMicroorganisms
The indigenous populations of the Arctic regions of Russia experience the lowest coverage of health-related services. We assessed the prevalence of hepatitis A, B, C, D and E viruses (HAV, HBV, HCV, HDV and HEV) among 367 healthy adult Native people of ...
Vera S. Kichatova   +12 more
doaj   +1 more source

Antivirals Targeting Coronavirus RNA‐Dependent RNA Polymerase and Main Protease: From Mechanisms of Action to Outcomes in COVID‐19 Clinical Trials

open access: yesMicrobial Biotechnology, Volume 19, Issue 4, April 2026.
The target sites of COVID‐19 antivirals discussed in the present opinion paper, namely the RNA dependent RNA polymerase Nsp12 and of the main viral protease Nsp5, are indicated by a red star in the overview of the replication cycle of coronavirus SARS‐CoV‐2.
Harald Brüssow
wiley   +1 more source

Hepatitis B [PDF]

open access: yes
Viral hepatitis is a term commonly used for several clinically similar yet etiologically and epidemiologically distinct diseases. Hepatitis A (formerly called infectious hepatitis) and hepatitis B (formerly called serum hepatitis) have been recognized as
Hepatitis B
core  

The Interaction Between Mental Distress and Opioid Maintenance Treatment Impacts Levels of Circulating Cytokines

open access: yesAddiction Biology, Volume 31, Issue 4, April 2026.
In patients with chronic HCV infection, mental distress was positively associated with circulating cytokines levels in non‐OMT patients, but showed the opposite pattern in patients receiving OMT. Interaction analyses confirmed that OMT modified the relationship between symptom burden and cytokines, particularly the pro‐inflammatory TNF, IL‐2, IL‐8 and ...
Kristin Nygård‐Odeh   +6 more
wiley   +1 more source

Bioinformatics and Immunohistochemistry Reveal the Diagnostic and Mechanistic Role of the Cuproptosis‐Related Genes SMOC2/THY1 in Liver Fibrosis

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 8, April 2026.
ABSTRACT Cuproptosis, a newly identified form of programmed cell death, inhibits liver fibrosis in hepatic stellate cells. However, how cuproptosis influences liver fibrosis in other cells remains to be determined. We aimed to develop a diagnostic model for cuproptosis and to further investigate its role in liver fibrosis.
Ranyan Gao   +11 more
wiley   +1 more source

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