Results 101 to 110 of about 38,307,498 (313)

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

RELATIONSHIP BETWEEN HEV AND HCV INFECTIONS IN HEMODIALYSIS PATIENTS

Turkish Journal of Nephrology, 2019
The hemodialysis patients, having high risks for viral hepatitis have a prevalence of18% for hepatitis E virus and 41.5% for hepatitis C virus in our country.
Gülendam BOZDAYI, Hasibe VERDİ, Ülver DERİCİ, Murat DURANAY, Seyyal ROTA, Özden UZUNALİMOĞLU   +5 more
doaj  

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source

Multiple Functions of Hepatitis E Virus ORF3

Microorganisms
Hepatitis E (Hepatitis E, HE) is an acute and chronic infectious hepatitis caused by hepatitis E virus (Hepatitis E Virus, HEV) infection, which is responsible for most acute hepatitis in the world and is a significant public health problem. The pathogen,
Fengyuan Jiao, Yu Zhao, Gengxu Zhou, Chi Meng, Lingjie Wang, Shengping Wu, Jixiang Li, Liting Cao, Bo Zhou, Yichen Luo, Hanwei Jiao   +10 more
doaj   +1 more source

Hepatitis B virus reactivation sustained by a hepatitis B virus surface antigen immune-escape mutant isolate in a patient who was hepatitis B core antibody positive during treatment with sofosbuvir and velpatasvir for hepatitis C virus infection: a case report

Journal of Medical Case Reports, 2019
Background Although several cases of hepatitis B virus reactivation have been described in patients with a history of hepatitis B virus infection while undergoing treatment for hepatitis C virus infection with direct acting antivirals, the question of ...
Luca Foroghi Biland, Ludovica Ferrari, Vincenzo Malagnino, Elisabetta Teti, Carlotta Cerva, Adele Gentile, Marianna Aragri, Romina Salpini, Valentina Svicher, Massimo Andreoni, Loredana Sarmati   +10 more
doaj   +1 more source

High mortality associated with an outbreak of hepatitis E among displaced persons in Darfur, Sudan [PDF]

, 2006
BACKGROUND: Hepatitis E virus (HEV) causes acute onset of jaundice and a high case-fatality ratio in pregnant women. We provide a clinical description of hospitalized case patients and assess the specific impact on pregnant women during a large epidemic ...
Nizou, Jacques-Yves, Klovstad, Hilde, J.-P. Guthmann, Nicand, Elisabeth, Guerin, Philippe Jean, P. J. Guerin, D. Boccia, J.-Y. Nizou, E. Nicand, Tatay, Mercedes, M. Tatay, Ciglenecki, Iza, H. Klovstad, Boccia, Delia, Guthmann, Jean-Paul, I. Ciglenecki, Hamid, Nuha, N. Hamid   +17 more
core   +2 more sources

Helicobacter pylori‐Induced Persistent IGF2BP1 Activation Promotes Ferroptosis Resistance in Gastric Tumorigenesis

Advanced Science, EarlyView.
Helicobacter pylori infection induces sustained upregulation of the RNA‐binding protein IGF2BP1 in gastric epithelial cells, establishing a persistent epitranscriptomic program. IGF2BP1 stabilizes SLC7A11 mRNA in an m6A‐dependent manner to suppress ferroptosis and promote epithelial survival under oxidative stress. Pharmacological inhibition of IGF2BP1
Jing Ning, Xin Guan, Xinyu Hao, Jing Zhang, Deyao Li, Ying Xiong, Wenlin Zhang, Xiurui Han, Yanfei Lang, Meiling Zhou, Mengjie Yang, Zhi Huang, Tinghui Qu, Ming Zu, Qiao Meng, Weiwei Fu, Fengmin Lu, Jing Zhang, Xiangmei Chen, Tong Liu, Shigang Ding   +20 more
wiley   +1 more source

Hepatitis E Virus [PDF]

Transfusion Medicine and Hemotherapy, 2015
Pauli, Georg, Aepfelbacher, Martin, Bauerfeind, Ursula, Blümel, Johannes, Burger, Reinhard, Gärtner, Barbara, Gröner, Albrecht, Gürtler, Lutz, Heiden, Margarethe, Hildebrandt, Martin, Jansen, Bernd, Offergeld, Ruth, Schlenkrich, Uwe, Schottstedt, Volkmar, Seitz, Rainer, Strobel, Johanna, Willkommen, Hannelore, Baylis, Sally A.   +17 more
openaire   +3 more sources

Escaping high viral load exhaustion: CD8 cells with altered tetramer binding in chronic hepatitis B virus infection [PDF]

, 2002
Deletion, anergy, and a spectrum of functional impairments can affect virus-specific CD8 cells in chronic viral infections. Here we characterize a low frequency population of CD8 cells present in chronic hepatitis B virus (HBV) infection which survive in
Antonio Bertoletti, Brown, D., Dusheiko, G., Geoff Dusheiko, Williams, R., George J.M. Webster, Webster, G.J.M., David Brown, Mala K. Maini, Stephanie Reignat, King, A., Suranjith L. Seneviratne, Roger Williams, Bertoletti, A., Reignat, S., Maini, M.K., Graham S. Ogg, Abigail King, Ogg, G.S., Seneviratne, S.L.   +19 more
core   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source