Results 1 to 10 of about 21,148 (182)

Mutant CTNNB1 and histological heterogeneity define metabolic subtypes of hepatoblastoma [PDF]

EMBO Molecular Medicine, 2017
Hepatoblastoma is the most common malignant pediatric liver cancer. Histological evaluation of tumor biopsies is used to distinguish among the different subtypes of hepatoblastoma, with fetal and embryonal representing the two main epithelial components.
Stefania Crippa, Pierre‐Benoit Ancey, Jessica Vazquez, Paolo Angelino, Anne‐Laure Rougemont, Catherine Guettier, Vincent Zoete, Mauro Delorenzi, Olivier Michielin, Etienne Meylan   +9 more
doaj   +4 more sources

ALKBH1 gene polymorphisms confer hepatoblastoma susceptibility in Chinese children [PDF]

Scientific Reports
Hepatoblastoma is the most common malignant liver tumor of embryonic origin in children; however, its underlying etiology remains unclear. N1-methyladenosine (m1A) modification is widely found in various human tissues and has been demonstrated to ...
Chongwei He, Lingling Pan, Xinhao Zeng, Hua Wang, Zhonghua Yang, Jiao Zhang, Yong Li, Li Li, Suhong Li, Jiwen Cheng, Yalan Song, Jing He, Chaoyang Chen   +12 more
doaj   +2 more sources

GATA4-targeted compounds induce apoptosis and diminish viability of hepatoblastoma cells. [PDF]

PLoS ONE
Hepatoblastoma is the most common pediatric liver tumor, and it primarily affects young children. Despite improved treatment results due to modern chemotherapy and advanced surgical techniques, there is urgent need to improve the long-term prognosis of ...
Sini M Kinnunen, Katja Eloranta, Marjut Pihlajoki, Mika J Välimäki, Saana Pohjavaara, Emilie Indersie, Stefano Cairo, Aarni Kuusinen, Heikki Ruskoaho, Markku Heikinheimo   +9 more
doaj   +2 more sources

Upregulation of the lncRNA MEG3 in Metastatic Hepatoblastoma [PDF]

Cells
Hepatoblastoma is the predominant primary liver malignancy in children, and outcomes remain poor for patients with metastatic disease. Long non-coding RNAs (lncRNAs) regulate tumor behavior, but their role in metastatic hepatoblastoma is not well defined.
Morgan L. Brown, Maryam G. Shaikh, Nazia Nazam, Ali M. Eakes, Pranava Nande, Abdulraheem Kaimari, Joel C. Opara, Jamie M. Aye, Karina J. Yoon, Elizabeth A. Beierle   +9 more
doaj   +2 more sources

Downregulation of transcription factor GATA4 sensitizes human hepatoblastoma cells to doxorubicin-induced apoptosis [PDF]

Tumor Biology, 2017
Hepatoblastoma, the most common type of pediatric liver cancer, is treated with a combination of surgery and chemotherapy. An essential drug in the treatment of hepatoblastoma is doxorubicin, which in high doses is cardiotoxic. This adverse effect is due
Tea Soini, Marjut Pihlajoki, Antti Kyrönlahti, Leif C Andersson, David B Wilson, Markku Heikinheimo   +5 more
doaj   +2 more sources

EZH2 is a key prognostic marker and therapeutic target in aggressive and proliferative hepatoblastoma [PDF]

Molecular Cancer
Background EZH2 is a histone methyltransferase and a key component of polycomb repressive complex 2 (PRC2). It plays a critical role in genome remodeling, gene regulation and acts through PRC2-dependent and independent mechanisms, which comprise ...
Fatma Zohra Khoubai, Alexia Calovoulos, Hélène Guillorit, Juan Carrillo-Reixach, Alvaro del Rio-Alvarez, Pierre Klein, Marina Simon Coma, Christophe Avignon, Benoit Rousseau, Lea Mora Charrot, Sandrine Fedou, Jean-William Dupuy, Laura Royo, Montse Domingo-Sàbat, Nadine Thézé, Géraldine Siegfried, Abdel-Majid Khatib, Stefano Cairo, Emilie Indersie, Buddhi Prakash Jain, Véronique Trézéguet, Etienne Gontier, François Lamoureux, Catherine Guettier, Charlotte Mussini, Martin Hagedorn, Carolina Armengol, Christophe F. Grosset   +27 more
doaj   +2 more sources

Incidence trends and survival prediction of hepatoblastoma in children: a population‐based study

Cancer Communications, 2019
Background Hepatoblastoma is a rare disease that nevertheless accounts for the majority of liver malignancies in children. Due to limited epidemiological data, therapy for hepatoblastoma tends to be individualized.
Georgios Polychronidis, Ulrike Heger, Arianeb Mehrabi   +2 more
exaly   +3 more sources

Association of the YTHDF2 rs3738067 A>G variant with hepatoblastoma risk: a multicenter case-control study in Chinese children [PDF]

BMC Cancer
Background As a rare cancer, hepatoblastoma is the most prevalent malignant liver tumor in children, yet its underlying causes are poorly understood.
Zhuo Wang, Jinhong Zhu, Wenli Zhang, Zhonghua Yang, Yong Li, Li Li, Suhong Li, Jiwen Cheng, Jiao Zhang, Jing He, Peng Yi   +10 more
doaj   +2 more sources

SKP2 ubiquitylation modifies IDH1 to regulate hepatoblastoma cell cycle and glucose metabolism [PDF]

BMC Cancer
Purpose Hepatoblastoma (HB) is the most common and lethal malignant solid tumor of liver in children. Targeting the progression of tumor glucose metabolism represents a promising strategy to attenuate the tumor promoting microenvironment.
Pengxiang Yu, Jiarong Li, Wei Feng, Tao Lei, Wen Jia, Yun He, Yang Bi   +6 more
doaj   +2 more sources

Malignant Hepatoblast‐Like Cells Sustain Stemness via IGF2‐Dependent Cholesterol Accumulation in Hepatoblastoma [PDF]

Advanced Science
Hepatoblastoma, the most aggressive childhood liver tumor, poses significant challenges due to limited knowledge of its pathogenesis, particularly in poorly differentiated advanced tumors where the prognosis is dismal.
Miao Ding, Siwei Mao, Han Wu, Sijia Fang, Ni Zhen, Tianshu Chen, Jiabei Zhu, Xiaochen Tang, Xiaoyang Wang, Fenyong Sun, Guoqing Zhu, Qiuhui Pan, Ji Ma   +12 more
doaj   +2 more sources