Results 1 to 10 of about 33,045 (192)

Resveratrol differentially regulates NAMPT and SIRT1 in Hepatocarcinoma cells and primary human hepatocytes. [PDF]

PLoS ONE, 2014
Resveratrol is reported to possess chemotherapeutic properties in several cancers. In this study, we wanted to investigate the molecular mechanisms of resveratrol-induced cell cycle arrest and apoptosis as well as the impact of resveratrol on NAMPT and ...
Susanne Schuster, Melanie Penke, Theresa Gorski, Stefanie Petzold-Quinque, Georg Damm, Rolf Gebhardt, Wieland Kiess, Antje Garten   +7 more
doaj   +5 more sources

Epigenetic repression of de novo cysteine synthetases induces intra-cellular accumulation of cysteine in hepatocarcinoma by up-regulating the cystine uptake transporter xCT [PDF]

Cancer & Metabolism
Background The metabolic reprogramming of amino acids is critical for cancer cell growth and survival. Notably, intracellular accumulation of cysteine is often observed in various cancers, suggesting its potential role in alleviating the oxidative stress
Tomoaki Yamauchi, Yumi Okano, Daishu Terada, Sai Yasukochi, Akito Tsuruta, Yuya Tsurudome, Kentaro Ushijima, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo   +9 more
doaj   +2 more sources

33-kDa ANXA3 isoform contributes to hepatocarcinogenesis via modulating ERK, PI3K/Akt-HIF and intrinsic apoptosis pathways

Journal of Advanced Research, 2021
Introduction: As a member of annexin family proteins, annexin A3 (ANXA3) has 36-kDa and 33-kDa isoforms. ANXA3 plays crucial roles in the tumorigenesis, aggressiveness and drug-resistance of cancers.
Chunmei Guo, Nannan Li, Chengyong Dong, Liming Wang, Zhaopeng Li, Qinlong Liu, Qinglai Ma, Frederick T. Greenaway, Yuxiang Tian, Lihong Hao, Shuqing Liu, Ming-Zhong Sun   +11 more
doaj   +1 more source

Late Recurrence of Hepatocellular Carcinoma in a Patient 10 Years after Liver Transplantation Unrelated to Transplanted Organ

Case Reports in Oncology, 2021
Liver transplantation (LTx) is an accepted method of hepatocellular carcinoma (HCC) treatment in cirrhotic patients; however, it has many limitations, and there is a substantial risk of recurrence.
Kornelia Morisson-Sarapak, Maciej Wrzesiński, Samir Zeair, Marta Wawrzynowicz-Syczewska   +3 more
doaj   +1 more source

Cirrhosis of the liver and hepatocellular carcinoma in the outcome of chronic hepatitis C: a case report

Лечащий Врач, 2023
The article presents a clinical case of cirrhosis of the liver of class C according to Child – Pugh in the outcome of chronic hepatitis C and with the development of primary liver cancer.
V. V. Makashova, Kh. G. Omarova, Zh. B. Ponezheva, O. S. Astrina, V. V. Breder, I. V. Pogrebnyakov, I. A. Dzhanyan, S. A. Magomedova   +7 more
doaj   +1 more source

An Automated Method for Classifying Liver Lesions in Contrast-Enhanced Ultrasound Imaging Based on Deep Learning Algorithms

Diagnostics, 2023
Background: Contrast-enhanced ultrasound (CEUS) is an important imaging modality in the diagnosis of liver tumors. By using contrast agent, a more detailed image is obtained.
Mădălin Mămuleanu, Cristiana Marinela Urhuț, Larisa Daniela Săndulescu, Constantin Kamal, Ana-Maria Pătrașcu, Alin Gabriel Ionescu, Mircea-Sebastian Șerbănescu, Costin Teodor Streba   +7 more
doaj   +1 more source

Photothermal effects of CuS-BSA nanoparticles on H22 hepatoma-bearing mice

Frontiers in Pharmacology, 2022
The objective of this study was to evaluate the in vivo application and photothermal ablation effects and mechanism of copper sulfide nanoparticles (CuS NPs) in hepatocellular carcinoma (HCC).
Xinyu Dun, Shuliang Liu, Nan Ge, Meng Liu, Ming Li, Jun Zhang, Hongxu Bao, Benying Li, Hua Zhang, Lianhua Cui   +9 more
doaj   +1 more source

The Emerging Role of Ferroptosis in Liver Cancers

Life, 2022
Liver cancer represents a global health challenge with worldwide growth. Hepatocellular carcinoma (HCC) is the most common type of liver cancer. Indeed, approximately 90% of HCC cases have a low survival rate. Moreover, cholangiocarcinoma (CC) is another
Arianna Casini, Stefano Leone, Rosa Vaccaro, Giorgio Vivacqua, Ludovica Ceci, Luigi Pannarale, Antonio Franchitto, Paolo Onori, Eugenio Gaudio, Romina Mancinelli   +9 more
doaj   +1 more source

Deep Learning Algorithms in the Automatic Segmentation of Liver Lesions in Ultrasound Investigations

Life, 2022
Background: The ultrasound is one of the most used medical imaging investigations worldwide. It is non-invasive and effective in assessing liver tumors or other types of parenchymal changes.
Mădălin Mămuleanu, Cristiana Marinela Urhuț, Larisa Daniela Săndulescu, Constantin Kamal, Ana-Maria Pătrașcu, Alin Gabriel Ionescu, Mircea-Sebastian Șerbănescu, Costin Teodor Streba   +7 more
doaj   +1 more source

A Novel Graphene Quantum Dot‐Based mRNA Delivery Platform

ChemistryOpen, 2021
Abstract: During the last decades, there has been growing interest in using therapeutic messager RNA (mRNA) together with drug delivery systems. Naked, unformulated mRNA is, however, unable to cross the cell membrane and is susceptible to degradation ...
Ya Liu, Prof. Changhong Zhao, Dr. Alan Sabirsh, Dr. Lilei Ye, Dr. Xiaoqiu Wu, Prof. Hongbin Lu, Prof. Johan Liu   +6 more
doaj   +1 more source