Results 91 to 100 of about 993,013 (333)
A prospective randomised, open-labeled, trial comparing sirolimus-containing versus mTOR-inhibitor-free immunosuppression in patients undergoing liver transplantation for hepatocellular carcinoma [PDF]
, 2010 Background: The potential anti-cancer effects of mammalian target of rapamycin (mTOR) inhibitors are being intensively studied. To date, however, few randomised clinical trials (RCT) have been performed to demonstrate anti-neoplastic effects in the pure ...Pinna, Antonio D., HIDALGO E, Bechstein, Wolf Otto, M. Heise, Duvoux, Christophe, Heise, Michael, Lerut, Jan, Koert P de Jong, Valente Umberto, Heikki Mäkisalo, Rudolf Steininger, F. Fandrich, SCHMIDT J, Beckebaum, S., Troisi, Roberto I., V. Mazzaferro, Rene Adam, Burra P., Strasser Simone I, Becker, T., Lamby, P.E., Neuhaus Peter, A. Schnitzbauer, Rochon, Justine, Mirza Darius F, Faendrich, Fred, Geissler E. K. ., Fandrich, F., STEININGER R, HEISE M, P. E. Lamby, Rostaing L., Turrion Victor, Chazouilleres, O., VAN HOEK B, Soderdahl G., GRAEB C, Gerd Otto, Georges-Philippe Pageaux, Schlitt H. J., Neville Jamieson, Hans J Schlitt, BURRA P, MAZZAFERRO V, Jong, K.P. de, W. O. Bechstein, Makisalo, H., Rossi, Giorgio, KONIGSRAINER A, Rostaing, Lionel, Soderdahl Gunnar, Rizell, Magnus,, Turrion, V.S., Wolf, P., Strasser, S.I., Jauch, K.W., Philippe Wolf, Mazzaferro V., Wolters H., Pageaux, Georges-Philippe, ZUELKE C, Simone I Strasser, BECKER T, Kneteman N. M., Lerut, Jan P., Johann P Hauss, Duvoux Christophe, Wolters, Heiner, Jamieson N., Zuelke Carl, OTTO G, PINNA AD, Hauss J. P., I. Mutzbauer, Strasser, Simone I, Bilbao, I., Beckebaum Susanne, Schnitzbauer Andreas A, Mutzbauer I., Rizell M., Schmidt, Jan, Koenigsrainer, Alfred, Kneteman, Norman M., WOLTERS H, Lerut Jan P, G.E. Rossi, Gugenheim J., Tim Scholz, K. W. Jauch, N. Jamieson, Wolf O Bechstein, V. Sanchez Turrion, Rossi Giorgio, Andre Roy, van Hoek Bart, COLLEDAN M, Fändrich Fred, Olivier Chazouillères, Roy Andre, RIZELL M, Jan Schmidt, Gugenheim, J., Sanchez Turrion, Victor, K. P. De Jong, Neuhaus, P., R. Troisi, de Jong Koert P, R. Adam, Christophe Duvoux, L. Rostaing, Fandrich, Fred, Graeb, C., Lamby, Philipp E., Philipp E Lamby, Geissler Edward K, NEUHAUS P, A. D. Pinna, J. Pirenne, Pinna, A.D., Schnitzbauer, Andreas, VALENTE U, Pinna Antonio D, Adam Rene, U. Valente, STRASSER SI, Heiner Wolters, Margreiter Raimund, M. Colledan, BILBAO I, Geissler, Edward K., Lerut, Jan P, Chazouillères O., Troisi, Roberto, Heise M., Darius F Mirza, Wolters, H., Antonio D Pinna, M. Rizell, Fändrich F., HAUSS JP, MARGREITER R, O. Chazouilleres, DE JONG KP, Ingrid Mutzbauer, Karl-Walter Jauch, Schlitt, H.J., CHAZOUILLERES O, Victor Sanchez Turrion, Cillo U., Rochon J., Lamby, Philipp E, JAUCH KW, Andreas A Schnitzbauer, Burra, Patrizia, G. Soderdahl, LERUT JP, Mutzbauer, Ingrid, Graeb, Christian, Hauss Johann P, FANDRICH F, Scholz Tim, Strasser S. I., Pinna, Antonio D, BECKEBAUM S, Königsrainer A., Becker, Thomas, Rostaing Lionel, Gunnar Soderdahl, Colledan Michele, MAKISALO H, Roy, A., Makisalo, Heikki, I. Bilbao, U. Cillo, Turrion V. S., Justine Rochon, de Jong, Koert P, Umberto Cillo, Steininger, R., Hoek, Bart van, Gugenheim Jean, G. P. Pageaux, Mutzbauer, I., Geissler, E.K., Kneteman, Norman M, Margreiter, R., Fred Fändrich, Itxarone Bilbao, Edward K Geissler, Pirenne, J., Norman M Kneteman, Colledan M., Chazouilleres, Olivier, Gugenheim, Jean, Carl Zuelke, Magnus Rizell, N. M. Kneteman, Burra, P., Königsrainer Alfred, Bilbao, Itxarone, Otto G., Jacques Pirenne, P. Burra, Mazzaferro, Vincenzo, A. Konigsrainer, Schmidt Jan, E. Hidalgo, Mirza D. F., SODERDAHL G, Mazzaferro Vincenzo, Alfred Königsrainer, Heise, M., Otto Gerd, Margreiter R., Schlitt, Hans J., J. Rochon, Mäkisalo H., Cillo Umberto, Troisi Roberto I, Rossi G., T. Becker, Lamby Philipp E, Zuelke, Carl, ROY A, Scholz T., TURRION VS, Steininger R., Schlitt, Hans J, Schmidt, J., Lamby P. E., Graeb C., Bechstein W. O., Mirza, Darius F, Otto, G., Steininger, Rudolf, Raimund Margreiter, TROISI RI, Adam R., Pirenne, Jacques, Zuelke, C., Jauch K. W., Patrizia Burra, Scholz, Tim, Geissler, Edward K, Königsrainer, Alfred, J. Schimdt, Bechstein, W.O., Hidalgo, E., S. L. Strasser, PAGEAUX GP, Thomas Becker, Hidalgo E., A. Roy, Roy A., Pageaux, G.P., G. Otto, Schnitzbauer, A.A., Umberto Valente, MIRZA DF, Lerut J. P., Mirza, D.F., ADAM R, Colledan, Michele, Mäkisalo Heikki, Ernest Hidalgo, C. Zuelke, Pageaux Georges-Philippe, J. P. Hauss, J. Gugenheim, Roberto I Troisi, Bilbao I., Mazzaferro, V., Otto, Gerd, Cillo, Umberto, WOLF P, Rostaing, L., SCHLITT HJ, Neuhaus P., ROSSI G, Hauss, Johann P., Mutzbauer Ingrid, Vincenzo Mazzaferro, Jamieson, N., Jauch Karl-Walter, Chazouillères Olivier, Schnitzbauer A. A., Adam, R., Schmidt J., Strasser, Simone I., Bechstein Wolf O, Wolf Philippe, P. Neuhaus, C. Duvoux, Pirenne Jacques, Hauss, Johann P, Becker Thomas, D. F. Mirza, Bilbao Itxarone, Valente, U., P. Wolf, Bart van Hoek, Duvoux, C., T. Scholz, Jamieson, Neville, ROCHON J, Jan P Lerut, Pageaux G. P., Scholz, T., Lionel Rostaing, Schnitzbauer, Andreas A, MUTZBAUER I, Lerut, J.P., Rizell, Magnus, H. Wolters, Bechstein, Wolf O., Steininger Rudolf, BECHSTEIN WO, R. Steininger, B. Van Hoek, Konigsrainer, A., Becker T., Wolters Heiner, de Jong, Koert P., Roy, Andre, Kneteman Norman M, Bechstein, Wolf O, Troisi, Roberto I, Schnitzbauer, Andreas A., Schlitt Hans J, J. P. Lerut, PINNA, ANTONIO DANIELE, Burra Patrizia, SCHOLZ T, Wolf P., Christian Graeb, PIRENNE J, Beckebaum, Susanne, Rochon Justine, DUVOUX C, Adam, Rene, van Hoek B., Margreiter, Raimund, van Hoek, Bart, LAMBY PE, Jamieson Neville, S. Beckebaum, Pirenne J., Hidalgo Ernest, Soderdahl, Gunnar, GUGENHEIM J, Rochon, J., Jean Gugenheim, Giorgio Rossi, Hauss, J.P., Duvoux C., KNETEMAN NM, C. Graeb, Turrion, Victor Sanchez, Rizell, M., H. J. Schlitt, CILLO U, GEISSLER EK, SCHNITZBAUER AA, JAMIESON N, Jauch, Karl-Walter, H. Makisalo, Beckebaum S., Peter Neuhaus, R. Margreiter, Rizell Magnus, Kneteman, N.M., Mirza, Darius F., E. K. Geissler, Rossi, G., Heise Michael, Michael Heise, Hoek, B. van, Hidalgo, Ernest, Michele Colledan, Wolf, Philippe, Troisi R. I., Zuelke C., Valente, Umberto, Neuhaus, Peter, Valente U., Soderdahl, G., ROSTAING L, de Jong K. P., Cillo, U., Graeb Christian, Susanne Beckebaum, Troisi, R.I., Colledan, M., Duvoux, C, Kneteman, NM, Schnitzbauer, AA, Rochon, J, Graeb, C, Adam, R, Bilbao, I, Zuelke, C, Burra, P, de, Jong KP +402 morecore +5 more sourcesMultifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy
Advanced Functional Materials, EarlyView.Schematic illustration of the engineered RN@FDT for multimodal tumor therapy. a) Fabrication of FD&DOX/TFA‐loaded RGD‐NNV (RN@FDT) and the light‐triggered disassemble of RN@FDT. b) After internalized by tumor cells, RN@FDT are disintegrated under NIR‐II laser irradiation to boost PTT and induce cell apoptosis.Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang +16 morewiley +1 more sourceSystematic Position Mapping of Split CRISPR‐Cas12a Activators Enables Highly Sensitive miRNA Detection and Cancer Cell Stratification
Advanced Science, EarlyView.ABSTRACT
Amplification‐free Cas12a diagnostics with split crRNA enable rapid and programmable target recognition, yet insufficient understanding of DNA activator architecture prevents predictable control over trans‐cleavage activity and sensitivity. Here we systematically map over 200 split DNA activator configurations by introducing nicks at every ...Xiaoyan Tang, Zhe Li, Yuning Lu, Miao Ma, Zijian Mo, Jiajun Ke, Xinyu Luan, Tiangang Luan, Junqiu Zhai +8 morewiley +1 more sourceA Programmable Calcification Nanoplatform for Loco‐Regional Calcification‐Immune Hepatocellular Carcinoma Therapy
Advanced Science, EarlyView.An in situ‐grown BP‐CaO2 nanoplatform supplies coordinated Ca2+, endogenous phosphate, and oxidative stress to convert tumor calcification from a passive endpoint into an active immune‐remodeling process. Widespread hydroxyapatite deposition is visualized by CT, while multi‐omics reveals MCOLN2 as a calcium‐responsive mediator linking biomineralization Long Liu, Peng Li, Zhixiang Lu, Shuqin Xu, Juanjuan Wang, Kai Ma, Haodong Yu, Can Zhou, Hu Chen, Gang Liu, Yi Lyu, Shuang Bai +11 morewiley +1 more sourceChronic HBV Infection Disrupts CCL5‐Secreting cNK Cells and Attenuates Liver Accumulation and Activation of DCs and HBV‐Specific T Cells
Advanced Science, EarlyView.ADORA2A activation suppresses NFκB‐dependent CCL5 production in cNK cells during chronic HBV infection, disrupting intrahepatic DC recruitment and HBV‐specific CD8+ T‐cell differentiation and function. Targeting the ADORA2A/NFκB/CCL5 axis restores antiviral immunity and facilitates HBV clearance.Ailu Yang, Yucan Wang, Yating Yu, Jing Wu, Cuiping Bao, Zixuan Wang, Qiuju Han, Zhigang Tian, Jian Zhang, Huajun Zhao +9 morewiley +1 more source
