Results 81 to 90 of about 993,013 (333)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Research Progress on Immune Checkpoint Inhibitors in Treatment of Hepatocellular Carcinoma

Zhongliu Fangzhi Yanjiu, 2023
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death, and most patients with HCC are diagnosed at an advanced stage.
CAO Jiali, XIONG Zhifan, JIN Ze, MENG Yajun, HUANG Yumei, ZHU Mengpei, WANG Mengmeng   +6 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Integrated analysis of single-cell and bulk RNA sequencing data reveals a cellular senescence-related signature in hepatocellular carcinoma

Frontiers in Cell and Developmental Biology
The mortality of hepatocellular carcinoma (HCC) is on the rise globally, particularly in the Western world, with etiology gradually shifting from virus-related liver diseases to metabolic disorders such as non-alcoholic fatty liver disease.
Lei Qiao, Lei Qiao, Zibo Xu, Yuheng Chen, Wenwei Chen, Yuan Liang, Yuan Liang, Yi Wei, Kang Wang, Yue Yu, Wei Yan   +10 more
doaj   +1 more source

Systemic treatment for hepatocellular carcinoma

Chronic Diseases and Translational Medicine, 2018
Hepatocellular carcinoma (HCC) is one of the most common cancers with high mortality worldwide. Treatment options for patients with advanced stage HCC remain a great challenge. However, novel agents especially small molecule tyrosine kinase inhibitor and
Manushi Aggarwal, Abeer Arain, Zhaohui Jin   +2 more
doaj   +1 more source

Clinical biomarkers in hepatocellular carcinoma HCC

Frontiers in Bioscience, 2010
The Authors make a review of the most important molecules used today for detecting and screening hepatocellular carcinoma, analyzing their known biological features, advantages and limits especially concerning differential diagnosis from cirrhosis and others diseases.
Marcello, Donati, Giovanna, Brancato, Angelo, Donati   +2 more
openaire   +2 more sources

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

CCDC110 promotes the progression of hepatocellular carcinoma by activating the TGF-β/SMAD signaling pathway through targeted regulation of TGFBR1

Cancer Cell International
Background Hepatocellular carcinoma (HCC) is recognized for its high growth rate, high degree of invasiveness, and tendency to spread, leading to a significant number of deaths.
Hao Shen, Haifeng Li, Haodong Tang
doaj   +1 more source

Protein profiling in hepatocellular carcinoma by label-free quantitative proteomics in two west african populations. [PDF]

, 2013
21.08.13 KB.
Maimuna E Mendy, Mohamed I F Sharif, Camey, Suzi Alves, Kessler, BM, Holger B Kramer, Pierre Hainaut, Hainaut, P, Simon D Taylor-Robinson, Ladep, Nimzing G., Kramer, Holger B., Maimuna E. Mendy (439585), Benedikt M. Kessler (216861), Hainaut Pierre, Cynthia Wright-Drakesmith, Nimzing G Ladep, Ladep Nimzing G., Pierre Hainaut (15065), Nimzing G. Ladep (439583), Fye, Haddy K. S, Kessler Benedikt M., da Costa Andre Nogueira, Ladep, NG, Kirk Gregory D., Hainaut, Pierre, Camey, S, Adam Jeng (439580), Kirk, Gregory D., Wright-Drakesmith, C, Suzi Camey, Alasana Bah, Taylor-Robinson Simon D., Bah, Alasana, Holger B. Kramer (221354), Taylor-Robinson, SD, Mendy, Maimuna E., Simon D. Taylor-Robinson (316045), Fye Haddy K. S., Sharif, MI, Taylor-Robinson, Simon D., da Costa, AN, Costa, Andre Nogueira da, Nogueira Da Costa, A, Kramer, HB, Gregory D Kirk, Sharif Mohamed I. F., Bah Alasana, Andre Nogueira da Costa, Jeng Adam, Gregory D. Kirk (199129), Mendy Maimuna E., Okeke, E, Haddy K S Fye, Andre Nogueira da Costa (320345), Camey Suzi, Cynthia Wright-Drakesmith (439578), Wright-Drakesmith Cynthia, Fye, HK, Okeke, Edith, Jeng, A, Adam Jeng, Alasana Bah (439581), Bah, A, Edith Okeke (439584), Jeng, Adam, Drakesmith, Cynthia Wright, Mendy, ME, Kirk, GD, Okeke Edith, Mohamed I. F. Sharif (439582), Kessler, Benedikt M., Kramer Holger B., Benedikt M Kessler, Haddy K. S. Fye (439577), Suzi Camey (439579), Edith Okeke, Sharif, Mohamed I. F.   +75 more
core   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source