Results 221 to 230 of about 541,993 (403)

Notch2 Directs aTreg Cell Fate toward Immunoregulation or Inflammatory Pyroptosis

open access: yesAdvanced Science, EarlyView.
Schematic illustration showing that the Notch2 intracellular domain (NICD2) facilitates pyroptosis resistance in activated Tregs through the RREB1/Foxo1 signaling pathway. In addition, Notch2‐mediated pyroptosis resistance in activated Tregs promotes immunoregulatory capacity, thereby attenuating Th2‐driven inflammatory responses in allergic rhinitis ...
Yue‐Long Qiao   +10 more
wiley   +1 more source

A monocarboxylate transporter required for hepatocyte secretion of ketone bodies during fasting [PDF]

open access: diamond, 2012
Sarah E. Hugo   +5 more
openalex   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

open access: yesAdvanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong   +5 more
wiley   +1 more source

Transcriptomic Profile of Directed Differentiation of iPSCs into Hepatocyte-like Cells. [PDF]

open access: yesInt J Mol Sci
Panchuk I   +7 more
europepmc   +1 more source

Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance

open access: yesNature, 2018
Devram S. Ghorpade   +8 more
semanticscholar   +1 more source

Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution

open access: yesAdvanced Science, EarlyView.
SPDL1‐L, a long isoform of SPDL1, is identified as a bona fide lipid droplet‐associated protein that acts as a dynein adaptor to drive perinuclear clustering of lipid droplets. By linking lipid droplets to the microtubule network, SPDL1‐L extends the function of SPDL1 beyond mitosis and contributes to lipid droplet organization and nuclear remodeling ...
Honggang Su   +10 more
wiley   +1 more source

Massive hepatic necrosis-associated acute liver failure. [PDF]

open access: yeseGastroenterology
Lin T, Tong C, Liebe R, Weng H.
europepmc   +1 more source

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