Results 221 to 230 of about 380,993 (362)

Comprehensive dose-dependent hepatorenal protective effects of <i>Ziziphus nummularia</i> leaf extract against quinolphos-induced toxicity in Wistar rats. [PDF]

Front Pharmacol
Rengaraj R, Arumugam S, Dharmaraj PK, Gokula V, Murugavel A, Musthafa MS, Multisanti CR, Faggio C.   +7 more
europepmc   +1 more source

Pathophysiology and fate of hepatocytes in a mouse model of mitochondrial hepatopathies

, 2007
Francisco J. Díaz, Sofía García, D Hernandez, Arie Regev, Adriana Rebelo, Jose Oca‐Cossio, Carlos T. Moraes   +6 more
openalex   +2 more sources

Oral Celastrol Nanomedicine Targeting Intestinal Antigen‐Presenting Cells to Effectively Mitigate Autoimmune Uveitis via Gut‐Retina Axis

Advanced Science, EarlyView.
Oral nanoCEL exhibits effective intestinal targeting of antigen‐presenting cells and restores the Th17/Treg balance in lymph nodes and spleen, ultimately protecting the blood‐retinal barrier by inhibiting peripheral immune cell infiltration and suppressing retinal glial cell activation.
Jinrun Chen, Yuqin Wu, Bofei Xu, Jiabei Hou, Yijing Li, Yuhan Hu, Yutuo Zhu, Wenqiao Zhang, Shuqi Feng, Huanting Jin, Yuchen Cheng, Yuanyuan Jin, Jianhong Zhou, Xingyi Li   +13 more
wiley   +1 more source

Hepatocyte-hepatic stellate cell interactions in liver fibrosis: Mechanisms and therapeutic implications. [PDF]

Hepatol Commun
Wang Z, Cao Z, Dong Y, Hong Y, Zuo L, Wang H.   +5 more
europepmc   +1 more source

Altered expression of base excision repair genes in response to high glucose-induced oxidative stress in HepG2 hepatocytes

, 2012
Jing Pang, Chao Xi, Yang Dai, Huan Gong, Tiemei Zhang   +4 more
openalex   +2 more sources

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

Advanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang, Yuchen Wang, Binbin Li, Xin Li, Chenyu Liu, Yanhao Chen, Cheng Tian, Dongmei Wang, Xiaosong Gu, Chunping Jiang, Yuda Wei, Qiurong Ding   +11 more
wiley   +1 more source

Chicken biliary exosomes ameliorate lipopolysaccharide-induced hepatocyte injury. [PDF]

Sci Rep
Zhao Y, Yang Y, Cheng Z, Wang G.
europepmc   +1 more source

Decoding hepatocyte ploidy [PDF]

Nature Reviews Gastroenterology & Hepatology, 2018
openaire   +2 more sources

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

Advanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao, Xing‐Rui Cao, Bai‐Qiang Li, Fu‐Ying Zhao, Jia‐Mei Wang, Rui‐Kang Gao, Zhi‐Peng Cao, Zhen‐Xian Du, Hua‐Qin Wang   +8 more
wiley   +1 more source

Role of hepatocyte-derived fibrinogen-related protein 1 as a serum biomarker in the diagnosis of community-acquired pneumonia and sepsis: A cross-sectional study. [PDF]

J Int Med Res
Wang G, Zhang L, Zhu X, Qian K, Zhu L, Chen B, Gu W, Guo T, Liu S.   +8 more
europepmc   +1 more source