Results 21 to 30 of about 200,853 (296)

Physiological Signaling and Structure of the HGF Receptor MET

Biomedicines, 2014
The “hepatocyte growth factor” also known as “scatter factor”, is a multifunctional cytokine with the peculiar ability of simultaneously triggering epithelial cell proliferation, movement and survival.
Gianluca Baldanzi, Andrea Graziani
doaj   +1 more source

Age-related changes in bile acid synthesis and hepatic nuclear receptor expression [PDF]

, 2007
BACKGROUND:Recent data highlighted the role of nuclear receptors in the transcriptional regulation of the limiting enzyme of bile acid synthesis, cholesterol 7alpha-hydroxylase, in cellular and animal models.
Anzivino, Claudia, Bertolotti, Marco, Carulli, Lucia, Carulli, Nicola, Crestani, M, De Fabiani, E, Del Puppo, M, Gabbi, C, Godio, C, Loria, P, Macchioni, D, Mitro, N, Ricchi, M, Rossi, Aldo   +13 more
core   +1 more source

Hepatocyte Growth Factor

, 2023
This work was supported by National Institutes of Health (USA) grants Z01 BC005626 and ZIA BC011124 to D. P. Bottaro.
Rubin, Jeffrey S., Bottaro, Donald P.
openaire   +1 more source

Microenvironment and tumor cells: two targets for new molecular therapies of hepatocellular carcinoma. [PDF]

, 2018
Hepatocellular carcinoma (HCC), is one of the most frequent human cancer and is characterized by a high mortality rate. The aggressiveness appears strictly related to the liver pathological background on which cancer develops.
Amicone, Laura, Marchetti, Alessandra
core   +1 more source

Functional consequence of the MET-T1010I polymorphism in breast cancer. [PDF]

, 2014
Major breast cancer predisposition genes, only account for approximately 30% of high-risk breast cancer families and only explain 15% of breast cancer familial relative risk.
Brown, Powel H, Chavez-MacGregor, Mariana, Chen, Ken, Eterovic, Agda K, Gagea, Mihai, Gonzalez-Angulo, Ana M, Hortobagyi, Gabriel N, Lei, Xiudong, Liu, Shuying, Mendelsohn, John, Meric-Bernstam, Funda, Mills, Gordon B, Nair, Lakshmy, Parinyanitikul, Napa, Tripathy, Debu, Ueno, Naoto T, Wang, Bailiang, Zheng, Xiaofeng, Zhou, Wanding   +18 more
core   +11 more sources

An interaction between hepatocyte growth factor and its receptor (c-MET) prolongs the survival of chronic lymphocytic leukemic cells through STAT3 phosphorylation: a potential role of mesenchymal cells in the disease

Haematologica, 2011
Background Chronic lymphocytic leukemia cells are characterized by an apparent longevity in vivo which is lost when they are cultured in vitro. Cellular interactions and factors provided by the microenvironment appear essential to cell survival and may ...
Paolo Giannoni, Silvia Scaglione, Rodolfo Quarto, Roberto Narcisi, Manuela Parodi, Enrico Balleari, Federica Barbieri, Alessandra Pattarozzi, Tullio Florio, Silvano Ferrini, Giorgio Corte, Daniela de Totero   +11 more
doaj   +1 more source

Molecular mechanisms controlling the phenotype and the EMT/MET dynamics of hepatocyte [PDF]

, 2014
The complex spatial and paracrine relationships between the various liver histotypes are essential for proper functioning of the hepatic parenchymal cells.
Fausto N, Lazarevich NL, Michelotti GA, Omenetti A, Spagnoli FM, Treyer A, Valdes F   +6 more
core   +3 more sources

Hepatocyte growth factor predicts failure of Fontan circulation

ESC Heart Failure, 2020
Aims This study aimed to assess the value of the hepatocyte growth factor (HGF) as an independent predictor of a Fontan circulation failure. Methods and results This retrospective case–control study included 34 consecutive patients (19 men and 15 women ...
Takuro Kojima, Moe Taki, Koichi Toda, Shota Muraji, Shigeki Yoshiba, Toshiki Kobayshi, Naokata Sumitomo   +6 more
doaj   +1 more source

Fetal growth restriction and hepatocyte growth factor [PDF]

Archives of Disease in Childhood - Fetal and Neonatal Edition, 1997
Fetal growth restriction remains one of the major problems currently facing obstetricians; it contributes significantly to preterm birth rates (both iatrogenic and idiopathic), together with perinatal morbidity and mortality.1 Recent epidemiological data suggest that “prenatal programming” due to intrauterine growth restriction (IUGR) may also ...
D A, Somerset, S C, Afford, A J, Strain, M D, Kilby   +3 more
openaire   +2 more sources

Vascular endothelium plays a key role in directing pulmonary epithelial cell differentiation. [PDF]

, 2017
The vascular endothelium is critical for induction of appropriate lineage differentiation in organogenesis. In this study, we report that dysfunctional pulmonary endothelium, resulting from the loss of matrix Gla protein (MGP), causes ectopic hepatic ...
Blazquez-Medela, Ana M, Boström, Kristina I, Fogelman, Alan M, Guihard, Pierre J, Jumabay, Medet, Spencer, Melissa J, Tontonoz, Peter, Wu, Xiuju, Yao, Jiayi, Yao, Yucheng   +9 more
core   +2 more sources