Results 121 to 130 of about 58,347 (252)

Transdifferentiation of Integrin Beta 1 High+ Skin Progenitor Cells Into Functional Hepatocytes. [PDF]

Stem Cells Int
Lim JH, Kim DH, Lee J, Jung CR, Kang HM.
europepmc   +1 more source

Mitochondrial dysfunction: Related diseases, influencing factors, and detection

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li, Shiyu Li, Wanying Chen, Ziyu Zhang, Chun Pan, Peng Lei, Cheng Cheng, Junyou Zhu, Hanxiao Sun, Zhenning Dai   +9 more
wiley   +1 more source

Alternative splicing: hallmark and therapeutic opportunity in metabolic liver disease. [PDF]

Gastroenterol Rep (Oxf)
Jiang M, Alqahtani SA, Seto WK, Yilmaz Y, Pan Z, Valenti L, Eslam M.   +6 more
europepmc   +1 more source

The Hsp90β Isoform: An Attractive Target for Drug Development

Medicinal Research Reviews, EarlyView.
ABSTRACT The beta isoform of 90 kDa heat shock protein (Hsp90β) plays a critical role in maintaining cellular proteostasis by assisting in the folding and refolding of proteins, which is essential for both normal cellular function and stress response.
Subhabrata Chaudhury, Terin D'Amico, Brian S. J. Blagg   +2 more
wiley   +1 more source

Alcohol-induced gut permeability defect through dysbiosis and enterocytic mitochondrial interference causing pro-inflammatory macrophages in a dose dependent manner. [PDF]

Sci Rep
Chancharoenthana W, Kamolratanakul S, Udompornpitak K, Wannigama DL, Schultz MJ, Leelahavanichkul A.   +5 more
europepmc   +1 more source

PGC‐1α Activation by Polyphenols: A Pathway to Thermogenesis

Molecular Nutrition &Food Research, EarlyView.
Polyphenols, derived from dietary sources such as berries, undergo digestion and interact with gut microbiota, leading to their metabolization in the liver. This process influences bile acid composition, which in turn activates PGC1α, a key regulator of mitochondrial biogenesis and thermogenesis.
Nicholas Vannuchi, Luciana Pisani
wiley   +1 more source

Role of mitogens in normal and pathological liver regeneration. [PDF]

Hepatol Commun
Vosough M, Shokouhian B, Sharbaf MA, Solhi R, Heidari Z, Seydi H, Hassan M, Devaraj E, Najimi M.   +8 more
europepmc   +1 more source

Angiogenesis as a Therapeutic Target of (Poly)phenols: Tackling Cancer and Vascular‐Related Complications

Molecular Nutrition &Food Research, EarlyView.
(Poly)phenols constitute a source of natural therapeutic molecules capable of targeting angiogenesis in different scenarios. This review summarizes the current evidence of the role of (poly)phenols in modulating angiogenesis. The reader can find a compilation of preclinical and human investigations describing pro‐ and anti‐angiogenic effects of these ...
María Ángeles Ávila‐Gálvez, Antonio Vico‐Padilla, Claus Schneider, Juan Carlos Espín, Antonio González‐Sarrías, Juan Antonio Giménez‐Bastida   +5 more
wiley   +1 more source

The role of ubiquitination and deubiquitination in the pathogenesis of non-alcoholic fatty liver disease. [PDF]

Front Immunol
Zhang L, Liu S, Zhao Q, Liu X, Zhang Q, Liu M, Zhao W.   +6 more
europepmc   +1 more source

The role of gut microbiota‐derived metabolites in neuroinflammation

Neuroprotection, EarlyView.
Gut microbiota‐derived metabolites accumulate in the brain, activating or inhibiting microglia and astrocytes, which affects neuroinflammatory progression. The gut microbiota converts the diet into a variety of metabolites, including bile acid, trimethylamine N‑oxide (TMAO), and indole.
Lingjie Mu, Yijie Wang
wiley   +1 more source