Results 151 to 160 of about 58,347 (252)

Telomere Position Effect‐Over Long Distances Acts as a Genome‐Wide Epigenetic Regulator Through a Common Alu Element

Aging Cell, EarlyView.
Proposed TPE‐OLD model. TPE‐OLD genes are defined by a progressive modulation of gene expression following telomere attrition. In our study, focusing on the molecular mechanism of TPE‐OLD, we found that the TPE‐OLD loop requires a cis‐signature corresponding to a newly evolved Alu repeats (AluY). The Alu repeat can be either in an intergenic region, as
Raphaël Chevalier, Victor Murcia Pienkowski, Nicolas Jullien, Leslie Caron, Pascal Verdier Pinard, Frédérique Magdinier, Jérôme D. Robin   +6 more
wiley   +1 more source

Chronic Inflammation and Immune Dysregulation in Metabolic-Dysfunction-Associated Steatotic Liver Disease Progression: From Steatosis to Hepatocellular Carcinoma. [PDF]

Biomedicines
Jee YM, Lee JY, Ryu T.
europepmc   +1 more source

Ecological Realism Accelerates Epigenetic Aging in Mice

Aging Cell, EarlyView.
Living environment shapes mammalian aging, but laboratory conditions lack the ecological realism of natural social, physical, and microbial environments. Comparing traditionally laboratory‐reared and “re‐wilded” C57BL/6J mice, we reveal accelerated, genomic region‐dependent epigenetic aging in the liver under naturalistic field conditions, highlighting
Matthew N. Zipple, Ivan Zhao, Daniel Chang Kuo, Sol Moe Lee, Michael J. Sheehan, Wanding Zhou   +5 more
wiley   +1 more source

Molecular Research on Diabetes. [PDF]

Int J Mol Sci
Puddu A, Maggi DC.
europepmc   +1 more source

Long‐term alcohol consumption and incident health risk conditions related to cardiometabolic risk markers: A 20‐year prospective cohort study

Addiction, EarlyView.
Abstract Background and aims Amid questions about a perceived association between low‐to‐moderate alcohol consumption and reduced cardiovascular risk from recent studies, research examining the impact of alcohol consumption on cardiometabolic risk markers has reported inconsistent results.
Sooyeun Choi, Taeyoung Park, Youjin Je
wiley   +1 more source

C/EBPβ transcription factor promotes alcohol-induced liver fibrosis in males via HDL remodeling. [PDF]

Hepatol Commun
Schonfeld M, Nataraj K, Weinman S, Tikhanovich I.   +3 more
europepmc   +1 more source

NETosis: A bridge between cancer and autoimmunity

Rheumatology &Autoimmunity, EarlyView.
Niloufar Orooji, Manouchehr Fadaee
wiley   +1 more source

The Lipidomic Profile Discriminates Between MASLD and MetALD

Alimentary Pharmacology &Therapeutics, Volume 61, Issue 8, Page 1357-1371, April 2025.
HDL‐centric lipidomic biomarkers, particularly within large and medium HDL subfractions, distinguish metabolic dysfunction and alcohol‐related liver disease from metabolic dysfunction‐associated steatotic liver disease, suggesting potential biomarkers for clinical differentiation.
Kai Markus Schneider, Feng Cao, Helen Ye Rim Huang, Lanlan Chen, Yazhou Chen, Rongpeng Gong, Anastasia Raptis, Kate Townsend Creasy, Jan Clusmann, Felix van Haag, Paul‐Henry Koop, Adrien Guillot, Tom Luedde, Rohit Loomba, Sven Francque, Carolin Victoria Schneider   +15 more
wiley   +1 more source

HNF-1β alleviates podocyte injury in lupus nephritis by maintaining endoplasmic reticulum homeostasis. [PDF]

Lupus Sci Med
Zou HM, Yu J, Ruan YY, Xie Y, An XM, Chen PL, Luo YQ, Shi MJ, Liu M, Xu LF, Liu J, Guo B, Zhang F.   +12 more
europepmc   +1 more source

Extracellular Vesicles miRNome Profiling Reveals miRNAs Engagement in Dysfunctional Lipid Metabolism, Chronic Inflammation and Liver Damage in Subjects With Metabolic Dysfunction‐Associated Steatotic Liver Disease

Alimentary Pharmacology &Therapeutics, EarlyView.
This study explores the association between the miRNome profile of circulating extracellular vesicles and metabolic dysfunction, liver inflammation, and damage in patients with metabolic MASLD, identifying key miRNAs (miR‐122‐5p, miR‐375‐3p, let‐7d‐5p, and let‐7f‐5p) that modulate lipid metabolism and inflammatory pathways in ‘at‐risk MASH’ patients ...
Gian Paolo Caviglia, Elisabetta Casalone, Chiara Rosso, Serena Aneli, Alessandra Allione, Fabrizia Carli, Cristina Grange, Angelo Armandi, Chiara Catalano, Giovanni Birolo, Beatrice Foglia, Davide Giuseppe Ribaldone, Amalia Gastaldelli, Giuseppe Matullo, Elisabetta Bugianesi   +14 more
wiley   +1 more source